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Depression beim gebrechlichen Alterspatienten

Diagnostik und Therapie

Depression in frail geriatric patients

Diagnostics and treatment

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Zusammenfassung

Gebrechlichkeit erhöht das Risiko einer depressiven Störung. Der vorliegende Beitrag gibt eine selektive Übersicht zu den Fragestellungen Koinzidenz von Depression und Gebrechlichkeit, Symptomatik, Diagnostik und Therapie der Depression bei gebrechlichen Menschen. Depressive Störungen im höheren Lebensalter sind durch eine zunehmende Häufigkeit und Intensität von somatischen Symptomen geprägt. Diese Symptome überlappen mit einigen Kriterien der Gebrechlichkeit. Beide Störungen weisen ein erhöhtes Risiko für eine Verschlechterung der körperlichen und seelischen Gesundheit, für Heimeinweisung und für Tod auf. Die Erfassung subsyndromaler depressiver Störungen bei gebrechlichen Menschen ermöglicht Perspektiven der Prävention. Bei präventiven und therapeutischen Maßnahmen ist besonderes Augenmerk auf Therapiesicherheit sowie einen barrierefreien Zugang zu Therapieangeboten zu legen. Da körperliche Begleitsymptome das Risiko einer Verschlechterung der Depression bedingen, müssen sie gemeinsam mit den psychischen Symptomen in einem fächerübergreifenden geriatrisch-gerontopsychiatrischen Therapiekonzept behandelt werden.

Abstract

Frailty is associated with an increased risk of depressive syndromes. This review aims to summarize data on coincidence, clinical presentation, and diagnostic and therapeutic work-up of depression in frail patients. Depressive syndromes in geriatric patients are characterized by increased frequency and intensity of somatic symptoms. There is considerable overlap with symptoms of frailty. Both syndromes indicate an increased risk for subsequent somatic morbidity, worsening depression functional deterioration, admission to a nursing home and mortality. Diagnosis of subthreshold depressive syndromes allows preventive measures to be initiated. Barrier-free access to preventive and therapeutic interventions is essential. Concomitant somatic symptoms in subthreshold depression increase risk of progression to major depression. They must be addressed in an interdisciplinary approach involving geriatric teams and geriatric psychiatry.

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Literatur

  1. Blumenthal JA, Babyak MA, O’Connor C et al (2012) Effects of exercise training on depressive symptoms in patients with chronic heart failure: the HF-ACTION randomized trial. JAMA 308:465–474

    Article  PubMed  CAS  Google Scholar 

  2. Braam AW, Prince MJ, Beekman AT et al (2005) Physical health and depressive symptoms in older Europeans. Results from EURODEP. Br J Psychiatry 187:35–42

    Article  PubMed  CAS  Google Scholar 

  3. Burkhardt H, Wehling M, Gladisch R (2007) Prevention of adverse drug reactions in older patients. Z Gerontol Geriatr 40:241–254

    Article  PubMed  CAS  Google Scholar 

  4. Coupland C, Dhiman P, Morriss R et al (2011) Antidepressant use and risk of adverse outcomes in older people: population based cohort study. BMJ 343:d4551

    Article  PubMed  Google Scholar 

  5. Danon-Hersch N, Rodondi N, Spagnoli J, Santos-Eggimann B (2012) Prefrailty and chronic morbidity in the youngest old: an insight from the Lausanne cohort lc65 +. J Am Geriatr Soc 60:1687–1694

    Article  PubMed  Google Scholar 

  6. Dirmaier J, Krattenmacher T, Watzke B et al (2010) Evidence-based treatments in the rehabilitation of patients with depression – a literature review. Psychother Psychosom Med Psychol 60:83–97

    Article  PubMed  Google Scholar 

  7. Ekerstad N, Swahn E, Janzon M et al (2011) Frailty is independently associated with short-term outcomes for elderly patients with non-ST-segment elevation myocardial infarction. Circulation 124(22):2397–2404

    Article  PubMed  Google Scholar 

  8. Flint AJ, Gagnon N (2002) Effective use of electroconvulsive therapy in late-life depression. Can J Psychiatry 47:734–741

    PubMed  Google Scholar 

  9. Fried LP, Tangen CM, Walston J et al (2001) Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 56:M146–M156

    Article  PubMed  CAS  Google Scholar 

  10. Gogulla S, Lemke N, Hauer K (2012) Effects of physical activity and physical training on the psychological status of older persons with and without cognitive impairment. Z Gerontol Geriatr 45:279–289

    Article  PubMed  CAS  Google Scholar 

  11. Harris Y, Cooper JK (2006) Depressive symptoms in older people predict nursing home admission. J Am Geriatr Soc 54:593–597

    Article  PubMed  Google Scholar 

  12. Harris Y (2007) Depression as a risk factor for nursing home admission among older individuals. J Am Med Dir Assoc 8:14–20

    Article  PubMed  Google Scholar 

  13. Hamilton M (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23:56–62

    Article  PubMed  CAS  Google Scholar 

  14. Hausner L, Damian M, Sartorius A, Frölich L (2012) Efficacy and cognitive side effects of electroconvulsive therapy (ECT) in depressed elderly inpatients with coexisting mild cognitive impairment or dementia. J Clin Psychiatry 72:91–97

    Article  Google Scholar 

  15. Hegeman JM, Kok RM, Mast RC van der, Giltay EJ (2012) Phenomenology of depression in older compared with younger adults: meta-analysis. Br J Psychiatry 200:275–281

    Article  PubMed  CAS  Google Scholar 

  16. Hummel J, Weisbrod C, Bösch L et al (2012) Acute illness and depression in the elderly and the influence of cognitive impairment: AIDE-cog trial. Z Gerontol Geriatr 45:34–39

    Article  PubMed  CAS  Google Scholar 

  17. Hummel J, Weisbrod C, Mueller-Wilmsen U et al (2012) New psychosocial interventions are needed in early dementia BMJ 345:e5991

  18. Kerse N, Hayman KJ, Moyes SA et al (2010) Home-based activity program for older people with depressive symptoms: DeLLITE – a randomized controlled trial. Ann Fam Med 8:214–223

    Article  PubMed  Google Scholar 

  19. Koenig HG, Johnson JL, Peterson BL (2006) Major depression and physical illness trajectories in heart failure and pulmonary disease. J Nerv Ment Dis 194:909–916

    Article  PubMed  Google Scholar 

  20. Kooy K van der, Hout H van, Marwijk H et al (2007) Depression and the risk for cardiovascular diseases: systematic review and meta analysis. Int J Geriatr Psychiatry 22:613–626

    Article  PubMed  Google Scholar 

  21. Lederbogen F, Kopf D, Hewer W (2008) An interdisciplinary unit for major psychiatric/somatic comorbidity: concept and 22 years of experience. Nervenarzt 79:1051–1058

    Article  PubMed  CAS  Google Scholar 

  22. Lyness JM, Kim J, Tang W et al (2007) The clinical significance of subsyndromal depression in older primary care patients. Am J Geriatr Psychiatry 15:214–223

    Article  PubMed  Google Scholar 

  23. Lyness JM, Yu Q, Tang W et al (2009) Risks for depression onset in primary care elderly patients: potential targets for preventive interventions. Am J Psychiatry 166:1375–1383

    Article  PubMed  Google Scholar 

  24. Meeks TW, Vahia IV, Lavretsky H et al (J Aff Dis 2011) A tune in „a minor“ can „b major“: a review of epidemiology, illness course, and public health implications of subthreshold depression in older adults. J Affect Disord 129:126–142

    Google Scholar 

  25. Mehta M, Whyte E, Lenze E et al (2008) Depressive symptoms in late life: associations with apathy, resilience and disability vary between young-old and old-old. Int J Geriatr Psychiatry 23:238–243

    Article  PubMed  Google Scholar 

  26. Pérès K, Jagger C, Matthews FE, MRC CFAS (2008) Impact of late-life self-reported emotional problems on disability-free life expectancy: results from the MRC cognitive function and ageing study. Int J Geriatr Psychiatry 23:643–649

    Article  PubMed  Google Scholar 

  27. Rapp MA, Schnaider-Beeri M, Wysocki M et al (2011) Cognitive decline in patients with dementia as a function of depression. Am J Geriatr Psychiatry 19:357–363

    Article  PubMed  Google Scholar 

  28. Rockwood K, Mitnitski A, Song X et al (2006) Long-term risks of death and institutionalization of elderly people in relation to deficit accumulation at age 70. J Am Geriatr Soc 54:975–979

    Article  PubMed  Google Scholar 

  29. Rockwood K, Song X, Mitnitski A (2011) Changes in relative fitness and frailty across the adult lifespan: evidence from the Canadian National Population Health Survey. CMAJ 183:E487–E494

    PubMed  Google Scholar 

  30. Schoevers RA, Geerlings MI, Deeg DJ et al (2009) Depression and excess mortality: evidence for a dose response relation in community living elderly. Int J Geriatr Psychiatry 24:169–176

    Article  PubMed  CAS  Google Scholar 

  31. Singh NA, Stavrinos TM, Scarbek Y et al (2005) A randomized controlled trial of high versus low intensity weight training versus general practitioner care for clinical depression in older adults. J Gerontol A Biol Sci Med Sci 60:768–776

    Article  PubMed  Google Scholar 

  32. Sumaya IC, Rienzi BM, Deegan JF 2nd, Moss DE (2001) Bright light treatment decreases depression in institutionalized older adults: a placebo-controlled crossover study. J Gerontol A Biol Sci Med Sci 56:M356–M360

    Article  PubMed  CAS  Google Scholar 

  33. Tedeschini E, Levkovitz Y, Iovieno N et al (2011) Efficacy of antidepressants for late-life depression: a meta-analysis and meta-regression of placebo-controlled randomized trials. J Clin Psychiatry 72:1660–1668

    Article  PubMed  CAS  Google Scholar 

  34. Wang PS, Schneeweiss S, Brookhart MA et al (2005) Suboptimal antidepressant use in the elderly. J Clin Psychopharmacol 25:118–126

    Article  PubMed  CAS  Google Scholar 

  35. Weyerer S, Bickel H (2007) Epidemiologie psychischer Erkrankungen im höheren Lebensalter. Grundriss Gerontologie, Bd 14. Kohlhammer, Stuttgart

  36. Whang W, Shimbo D, Kronish IM et al (2010) Depressive symptoms and all-cause mortality in unstable angina pectoris (from the Coronary Psychosocial Evaluation Studies [COPES]). Am J Cardiol 106:1104–1107

    Article  PubMed  Google Scholar 

  37. Yesavage JA, Brink TL, Rose TL et al (1982) Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res 17:37–49

    Article  PubMed  Google Scholar 

  38. Zigmond AS, Snaith RP (1983) The hospital anxiety and depression scale. Acta Psychiatr Scand 67:361–370

    Article  PubMed  CAS  Google Scholar 

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Interessenkonflikt

Der korrespondierende Autor weist für sich und seine Koautorin auf folgende Beziehungen hin: D.K. hat Honorare für Fortbildungsvorträge und Unterstützung für Fortbildungsveranstaltungen von den Firmen Lilly Deutschland GmbH und Lundbeck erhalten. Bei J.H. besteht kein Interessenkonflikt.

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Kopf, D., Hummel, J. Depression beim gebrechlichen Alterspatienten. Z Gerontol Geriat 46, 127–133 (2013). https://doi.org/10.1007/s00391-012-0461-9

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