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Gefäßalterung

Die Rolle von oxidativem Stress und Proteinglykierung

Vessel aging

The role of oxidative stress and protein glycation

Zeitschrift für Gerontologie und Geriatrie volume 44, pages 146–152 (2011)Cite this article

Zusammenfassung

Langsam ablaufende primäre Alterungsmechanismen führen zu anfangs unbemerkten Veränderungen im Gefäßsystem. Die endotheliale Dysfunktion ist ein früher Marker der Gefäßalterung. Ursache ist oxidativer Stress, der einerseits durch eine Reduktion der Bioverfügbarkeit von Stickstoffmonoxid (NO) und andererseits durch die Nitrosylierung wichtiger zellulärer Proteine vermittelt wird. Parallel dazu kommt es durch die Glykierung der extrazellulären Matrix zur Versteifung der Gefäße. In Kombination mit dem Verlust der elastischen Fasern wie Elastin führen diese Komponenten zu altersbedingten Gefäßveränderungen. Das Verständnis der Wirkung primärer Alterungsmechanismen könnte die Basis für die Entwicklung neuer Medikamente bilden.

Abstract

The slow procession of the primary mechanisms of aging lead, at first, to unnoticed changes in the vascular system. Endothelial dysfunction is one of the earliest markers in aging vessels, caused by oxidative stress via the reduction of the availability of NO, on the one hand, and the nitrosylation of proteins, on the other hand. At the same time, glycation of the proteins of the extracellular matrix leads to stiffening of the vessel wall. Together with the loss of elastic fibers, e.g., elastin, this leads to the age-related changes of the vessels. Knowledge of these primary mechanisms of aging may lead to the development of new drugs.

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  1. Klinik für Herz- und Thoraxchirurgie, Interdisziplinäres Zentrum Altern in Halle (IZAH), Universitätsklinikum Halle (Saale), Ernst-Grube Str. 40, 06120, Halle, Deutschland

    A. Simm

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Simm, A. Gefäßalterung. Z Gerontol Geriat 44, 146–152 (2011). https://doi.org/10.1007/s00391-011-0200-7

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  • DOI: https://doi.org/10.1007/s00391-011-0200-7

Schlüsselwörter

  • Altern
  • Reaktive Sauerstoffspezies
  • Oxidativer Stress
  • „Advanced glycation end products“
  • Endotheliale Dysfunktion

Keywords

  • Aging
  • Reactive oxygen species
  • Oxidative stress
  • Advanced glycation end products
  • Endothelial dysfunction