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Stellungnahme zum IQWiG-Vorbericht A05-19B „Ginkgohaltige Präparate bei Alzheimer Demenz“

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References

  1. IQWiG. Ginkgohaltige Präparate bei Alzheimer Demenz. Vorbericht A05- 19B. Köln: Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen (IQWiG); Dezember 2006. http:// www.iqwig.de/download/A05-19BVorbericht_ V1%200.pdf (Zugriff 16. 01. 2007)

  2. IQWiG. Methoden. Version 2.0 vom 19. 12. 2006. Köln: Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen (IQWiG); Dezember 2006. http://www.iqwig.de/download/ 2006_12_19_IQWiG_Methoden_V-2- 0.pdf (Zugriff 16. 01. 2007)

  3. Birks J, Grimley Evans J (2006) Ginkgo biloba for cognitive impairment and dementia. The Cochrane Database of Systematic Reviews. Issue 3. CD003120

  4. Kanowski S, Hoerr R (2003) Ginkgo biloba extract EGb 761® in dementia: intent-to-treat analyses of a 24-week, multi-center, double-blind, placebocontrolled, randomized trial. Pharmacopsychiatry 36:297–303

    Article  PubMed  CAS  Google Scholar 

  5. Le Bars PL, Katz MM, Berman N et al (1997) A placebo-controlled, double- blind, randomized trial of an extract of Ginkgo biloba for dementia. JAMA 278:1327–1332

    Article  PubMed  CAS  Google Scholar 

  6. Le Bars PL, Velasco FM, Ferguson JM et al (2002) Influence of the severity of cognitive impairment on the effect of the Ginkgo biloba extract EGb 761® in Alzheimer’s disease. Neuropsychobiology 45:19–26

    Article  PubMed  CAS  Google Scholar 

  7. Schneider LS, DeKosky ST, Farlow MR et al (2005) A randomized, double- blind, placebo-controlled trial of two doses of Ginkgo biloba extract in dementia of the Alzheimer’s type. Curr Alzheimer Res 2:541–551

    Article  PubMed  CAS  Google Scholar 

  8. Mazza M, Capuano A, Bria P et al (2006) Ginkgo biloba and donepezil: a comparison in the treatment of Alzheimer’s dementia in a randomized placebo-controlled double-blind study. Eur J Neurol 13:981–985

    Article  PubMed  CAS  Google Scholar 

  9. Langa KM, Foster NL, Larson EB (2004) Mixed dementia. Emerging concepts and therapeutic implications. JAMA 292:2901–2908

    Article  PubMed  CAS  Google Scholar 

  10. Boustani M, Peterson B, Hanson L et al (2003) Screening for dementia in primary care: a summary of the evidence for the US Preventive Services Task Force. Ann Intern Med 138:927–937

    PubMed  Google Scholar 

  11. Mayeux R, Sano M (1999) Treatment of Alzheimer’s disease. N Engl J Med 341:1670–1679

    Article  PubMed  CAS  Google Scholar 

  12. De Smet PAGM (2002) Herbal remedies. N Engl J Med 347:2046–2056

    Article  PubMed  Google Scholar 

  13. Kawas CH (2003) Early Alzheimer’s disease. N Engl J Med 349:1056–1063

    Article  PubMed  CAS  Google Scholar 

  14. Ahlemeyer B, Krieglstein J (2003) Pharmacological studies supporting the therapeutic use of Ginkgo biloba extract for Alzheimer’s disease. Pharmacopsychiatry 36(Suppl 3):S8–14

    Article  PubMed  CAS  Google Scholar 

  15. Le Bars PL (2003) Response patterns of EGb 761® in Alzheimer’s disease: influence of neuropsychological profiles. Pharmacopsychiatry 36(Suppl 3):S50–55

    Article  PubMed  CAS  Google Scholar 

  16. Hoerr R (2003) Behavioural and psychological symptoms of dementia (BPSD): effects of EGb 761®. Pharmacopsychiatry 36(Suppl 3):S56–61

    Article  PubMed  CAS  Google Scholar 

  17. Le Bars PL (2003) Magnitude of effect and special approach to Ginkgo biloba extract EGb 761® in cognitive disorders. Pharmacopsychiatry 36 (Suppl 3):S44–49

    Article  PubMed  CAS  Google Scholar 

  18. Van Dongen MCJM, van Rossum E, Kessels AGH et al (2000) The efficacy of Ginkgo for elderly people with dementia and age-associated memory impairments: new results of a randomized clinical trial. J Am Geriatr Soc 48:1183–1194

    PubMed  CAS  Google Scholar 

  19. Elsabagh S, Hartley DE, File SE (2005) Limited cognitive benefits in stage +2 postmenopausal women after 6 weeks of treatment with Ginkgo biloba. J Psychopharm 19:173–181

    Article  CAS  Google Scholar 

  20. Geldmacher DS (2003) Alzheimer’s disease: current pharmacotherapy in the context of patient and family needs. J Am Geriatr Soc 51(5s2): S289–295

    Article  PubMed  Google Scholar 

  21. Gauthier S (1999) Do we have a treatment for Alzheimer’s disease. Yes. Arch Neurol 56:738–739

    Article  PubMed  CAS  Google Scholar 

  22. Pryse-Phillips W (1999) Do we have drugs for dementia? No. Arch Neurol 56:735–737

    Article  PubMed  CAS  Google Scholar 

  23. Maidment I (2001) The use of ginkgo biloba in the treatment of dementia. Psychiatric Bulletin 25:353–356

    Article  Google Scholar 

  24. Ohen BS, Storzbach DM, Kaye JA (1998) The efficacy of Ginkgo biloba on cognitive function in Alzheimer disease. Arch Neurol 55:1409–1415

    Article  Google Scholar 

  25. Salomon PR, Adams F, Silver A et al (2002) Ginkgo for memory enhancement. A randomized controlled trial. JAMA 2888:835–840

    Article  Google Scholar 

  26. Costa LG, Steardo L, Cuomo V (2004) Structural effects and neurofunctional sequelae of development exposure to psychotherapeutic drugs: experimental and clinical aspects. Pharmacol Rev 56:103–147

    Article  PubMed  CAS  Google Scholar 

  27. Chiapelli F, Navarro AM, Moradi DR et al (2006) Evidence-based research in complementary and alternative medicine III: Treatment of patients with Alzheimer’s disease. Evid Based Complement Alternat Med 3:411–424

    Article  Google Scholar 

  28. Fisher, Morley (2002) Antiaging medicine: the good, the bad, and the ugly. J Gerontol A Biol Sci Med Sci 57:M636–639

    PubMed  Google Scholar 

  29. DeKosky ST (2003) Pathology and pathways of Alzheimer’s disease with an update on new developments in treatment. J Am Geriatr Soc 51:S314–320

    Article  PubMed  Google Scholar 

  30. Geldmacher DS (2003) Alzheimer’s disease: current pharmacotherapy in the context of patient and family needs. J Am Geriatr Soc 51:S289–295

    Article  PubMed  Google Scholar 

  31. McDougall GJ, Austin-Wells V, Zimmermann T (2005) Utility of neutraceutical products marketed for cognitive and memory enhancement. J Hol Nursing 23:415–433

    Article  Google Scholar 

  32. Andrieu S, Gillette S, Amouyal K et al (2003) Association of Alzheimer’s disease onset with ginkgo biloba and other symptomatic cognitive treatments in a population of women aged 75 and older from the EPIDOS study. J Gerontol A Biol Sci Med Sci 58:M372–377

    Google Scholar 

  33. Van Dongen M, van Rossum E, Kessels A et al (2003) Ginkgo for elderly people with dementia and age-associated memory impairment: a randomized clinical trial. J Clin Epidemiol 56:367–376

    Article  PubMed  Google Scholar 

  34. Wong AHC, Smith M, Boon HS (1998) Herbal remedies in psychiatric practise. Arch Gen Psychiatry 55:1033–1044

    Article  PubMed  CAS  Google Scholar 

  35. Gogol M, Lüttje D, Werner H (2007) Stellungnahme zum Vorbericht des IQWiG „Cholinesterasehemmer bei Alzheimer Demenz“. Z Gerontol Geriat (im Druck)

  36. Scottish Intercollegiate Guidelines Network (SIGN). Management of patients with dementia. A national clinical guideline. Nr. 85, February 2006. http://www.sign.ac.uk/pdf/sign86.pdf (Zugriff 16. 01. 2007)

  37. Doody RS, Stevens JC, Beck C et al (2001) Practise parameter: management of dementia (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 56:1154–1166

    PubMed  CAS  Google Scholar 

  38. Burns A, O‘Brien (2006) Clinical practice with anti-dementiva drugs: a consensus statement from British Association for Psychopharmacology. J Psychopharm 20:732–755

    Article  CAS  Google Scholar 

  39. Warner J: DIGGER trial (Dementia in general practice: Ginkgo extract research trial). http://www.controlledtrials. com/ISRCTN 45577048

  40. NIH awards multicenter study on Ginkgo biloba for dementia. http:// www.nih.gov/news/pr/sept99/ nccam-30.htm (Zugriff 16. 01. 2007)

  41. Nahin RL, Fitzpatrick AL, Williamson JD et al (2006) Use of herbal medicine and other dietary supplements in community-dwelling older people: Baseline data from the Ginkgo Evaluation of Memory Study. J Am Geriatr Soc 54:1725–1735

    Article  PubMed  Google Scholar 

  42. Vellas B, Andrieu S, Ousset PJ et al (2006) The Guid Age study. Methodological issues. A 5-year double-blind randomized trial of the efficacy of EGb 761® for prevention of Alzheimer disease in patients over 70 with a memory complaint. Neurology 67 (Suppl 3):S6–11

    PubMed  CAS  Google Scholar 

  43. Bundessozialgericht B 1 KR 7/05R vom 4. 4. 2006. http://juris. bundessozialgericht. de/cgi-bin/neu_entw_bsg/ document.py?Gericht=bsg&Art=en &sid=38917c0152f11cf2c0e478dc 27440985&nr=9550&pos=0&anz=1 (Zugriff 19. 01. 2006)

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Authors and Affiliations

  1. Klinik für Geriatrie, Krankenhaus Lindenbrunn, Lindenbrunn 1, 31863, Coppenbrügge, Germany

    Manfred Gogol

  2. Klinik für Geriatrie, Klinikum Osnabrück, Sedanstr. 115, 49090, Osnabrück, Germany

    Dieter Lüttje

  3. Klinikum Nord, Lehrstuhl Innere Medizin V (Geriatrie), Prof.-Ernst-Nathan-Str. 1, 90419, Nürnberg, Germany

    Cornel Sieber

  4. Klinik für Geriatrie, Evangelisches Krankenhaus Elisabethenstift, Landgraf-Georg-Str. 100, 64287, Darmstadt, Germany

    Hansjörg Werner

Authors
  1. Manfred Gogol
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  2. Dieter Lüttje
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  3. Cornel Sieber
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  4. Hansjörg Werner
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Corresponding author

Correspondence to Manfred Gogol.

Additional information

Dr. med. Manfred Gogol, Vorsitzender Sektion II Deutsche Gesellschaft für Gerontologie und Geriatrie (DGGG)

Prof. Dr. med. Dieter Lüttje, Vorsitzender Bundesarbeitsgemeinschaft Klinisch-Geriatrischer Einrichtungen (BAG Geriatrie)

Prof. Dr. med. Cornel Sieber, Präsident Deutsche Gesellschaft für Geriatrie (DGG)

Dr. med. Hansjörg Werner, Vorsitzender Sektion Geriatrie im Berufsverband Deutscher Internisten (BDI)

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Gogol, M., Lüttje, D., Sieber, C. et al. Stellungnahme zum IQWiG-Vorbericht A05-19B „Ginkgohaltige Präparate bei Alzheimer Demenz“. Z Gerontol Geriat 40, 282–284 (2007). https://doi.org/10.1007/s00391-007-0475-x

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  • DOI: https://doi.org/10.1007/s00391-007-0475-x

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