Treatment of acute strangulated internal hemorrhoids by topical application of isosorbide dinitrate ointment

Abstract.

Exogenous nitric oxide has been shown useful in decreasing the internal anal sphincter tone. This study investigated the role of isosorbide dinitrate in the treatment of patients with acute strangulated internal hemorrhoids, thereby avoiding the risk of continence disturbances following conventional surgical treatment. Four male patients (median age 35 years, range 30–42) with acute strangulated hemorrhoids were treated with 1% isosorbide dinitrate. The ointment was applied to the anoderm. This application was repeated every 3 h during daytime for 2 weeks. Significant pain relief was achieved within 1 day, while transient mild headache was experienced during the first 2 days. Within 1 week the hemorrhoids became reducible. Thereafter the hemorrhoids could be treated adequately by rubber band ligation. The alternative treatment of patients with acute strangulation of prolapsed internal hemorrhoids is effective. This nonsurgical, i.e., reversible reduction of sphincter tone is an attractive alternative.

This is a preview of subscription content, log in to check access.

Author information

Affiliations

Authors

Additional information

Electronic Publication

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Briel, J., Zimmerman, D. & Schouten, W. Treatment of acute strangulated internal hemorrhoids by topical application of isosorbide dinitrate ointment. Int J Colorectal Dis 15, 253–254 (2000). https://doi.org/10.1007/s003840000235

Download citation

  • Acute strangulated internal hemorrhoids Isosorbide dinitrate