Skip to main content

Advertisement

SpringerLink
Log in

Fecal microbiota transplantation for induction of remission in Crohn’s disease: a systematic review and meta-analysis

  • REVIEW
  • Published:
International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Purpose

Fecal microbiota transplantation (FMT) has been found to be a potential treatment for Crohn's disease (CD). We sought to perform a systematic review and meta-analysis to evaluate the efficacy and safety of FMT in CD.

Methods

Electronic databases were searched for studies until January 2023. Clinical remission was established as the primary outcome. The secondary outcome was clinical response, endoscopic remission, minor adverse events, serious adverse events, and changes in disease activity indices, biochemical indicators, and microbial diversities. Pooled effect sizes and 95% confidence intervals (CIs) were calculated under the random effects model.

Results

Eleven cohort studies and one randomized controlled trial involving 228 patients were included. In a meta-analysis, the pooled proportion of adult patients with active CD that achieved clinical remission 2 to 4 weeks after FMT was 57% (95% CI = 49–64%) with a low risk of heterogeneity (I2 = 37%). Furthermore, our results showed that FMT significantly (standardized mean difference = −0.66; 95% CI = −1.12 to −0.20; I2 = 0) reduced Crohn’s disease activity index scores 4 to 8 weeks after FMT. Subgroup analyses showed no difference between FMT methodologies, except for pre-FMT treatment with antibiotics (P = 0.02). Most adverse events were self-limiting and disappeared spontaneously within hours or days after FMT. Microbiota analysis showed an increased Shannon diversity and a shift toward donor-like microbiome after FMT.

Conclusion

FMT could be a promising therapy in the short-term treatment of active CD. More placebo-controlled randomized trials with a long-term follow-up treatment are necessary.

Trial registration

https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022322694 No. CRD42022322694.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

Data availability

The data underlying this article are available in the article and in its online supplementary material.

References

  1. Baumgart DC, Sandborn WJ (2012) Crohn’s disease. Lancet 380:1590–1605. https://doi.org/10.1016/S0140-6736(12)60026-9

    Article  PubMed  Google Scholar 

  2. Cosnes J, Cattan S, Blain A, Beaugerie L, Carbonnel F, Parc R, Gendre J-P (2002) Long-term evolution of disease behavior of Crohn’s disease. Inflamm Bowel Dis 8:244–250. https://doi.org/10.1097/00054725-200207000-00002

    Article  PubMed  Google Scholar 

  3. Chu H, Khosravi A, Kusumawardhani IP, Kwon AHK, Vasconcelos AC, Cunha LD, Mayer AE, Shen Y, Wu W-L, Kambal A, Targan SR, Xavier RJ, Ernst PB, Green DR, McGovern DPB, Virgin HW, Mazmanian SK (2016) Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease. Science 352:1116–1120. https://doi.org/10.1126/science.aad9948

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Franzosa EA, Sirota-Madi A, Avila-Pacheco J, Fornelos N, Haiser HJ, Reinker S, Vatanen T, Hall AB, Mallick H, McIver LJ, Sauk JS, Wilson RG, Stevens BW, Scott JM, Pierce K, Deik AA, Bullock K, Imhann F, Porter JA, Zhernakova A, Fu J, Weersma RK, Wijmenga C, Clish CB, Vlamakis H, Huttenhower C, Xavier RJ (2019) Gut microbiome structure and metabolic activity in inflammatory bowel disease. Nat Microbiol 4:293–305. https://doi.org/10.1038/s41564-018-0306-4

    Article  CAS  PubMed  Google Scholar 

  5. Vaughn BP, Vatanen T, Allegretti JR, Bai A, Xavier RJ, Korzenik J, Gevers D, Ting A, Robson SC, Moss AC (2016) Increased intestinal microbial diversity following fecal microbiota transplant for active Crohn’s disease. Inflamm Bowel Dis 22:2182–2190. https://doi.org/10.1097/mib.0000000000000893

    Article  PubMed  Google Scholar 

  6. Frank DN, St Amand AL, Feldman RA, Boedeker EC, Harpaz N, Pace NR (2007) Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci USA 104:13780–13785. https://doi.org/10.1073/pnas.0706625104

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Pascal V, Pozuelo M, Borruel N, Casellas F, Campos D, Santiago A, Martinez X, Varela E, Sarrabayrouse G, Machiels K, Vermeire S, Sokol H, Guarner F, Manichanh C (2017) A microbial signature for Crohn’s disease. Gut 66:813–822. https://doi.org/10.1136/gutjnl-2016-313235

    Article  CAS  PubMed  Google Scholar 

  8. Cheng F, Huang Z, Wei W, Li Z (2021) Fecal microbiota transplantation for Crohn’s disease: a systematic review and meta-analysis. Tech Coloproctol 25:495–504. https://doi.org/10.1007/s10151-020-02395-3

    Article  CAS  PubMed  Google Scholar 

  9. Li Q, Ding X, Liu Y, Marcella C, Dai M, Zhang T, Bai J, Xiang L, Wen Q, Cui B, Zhang F (2021) Fecal microbiota transplantation is a promising switch therapy for patients with prior failure of infliximab in Crohn’s disease. Front Pharmacol 12:658087. https://doi.org/10.3389/fphar.2021.658087

  10. Guo X, Huang C, Xu J, Xu H, Liu L, Zhao H, Wang J, Huang W, Peng W, Chen Y, Nie Y, Zhou Y, Zhou Y (2021) Gut microbiota is a potential biomarker in inflammatory bowel disease. Front Nutr 8:818902. https://doi.org/10.3389/fnut.2021.818902

  11. Osaki H, Jodai Y, Koyama K, Omori T, Horiguchi N, Kamano T, Funasaka K, Nagasaka M, Nakagawa Y, Shibata T, Ohmiya N (2021) Clinical response and changes in the fecal microbiota and metabolite levels after fecal microbiota transplantation in patients with inflammatory bowel disease and recurrent infection. Fujita Med J 7:87–98. https://doi.org/10.20407/fmj.2020-021

  12. Vermeire S, Joossens M, Verbeke K, Hildebrand F, Machiels K, Van den Broeck K, Van Assche G, Rutgeerts PJ, Raes J (2012) Pilot study on the safety and efficacy of faecal microbiota transplantation in refractory Crohn’s disease. Gastroenterology 142:S360–S360

    Article  Google Scholar 

  13. Cammarota G, Ianiro G, Tilg H, Rajilić-Stojanović M, Kump P, Satokari R, Sokol H, Arkkila P, Pintus C, Hart A, Segal J, Aloi M, Masucci L, Molinaro A, Scaldaferri F, Gasbarrini G, Lopez-Sanroman A, Link A, de Groot P, de Vos WM, Högenauer C, Malfertheiner P, Mattila E, Milosavljević T, Nieuwdorp M, Sanguinetti M, Simren M, Gasbarrini A (2017) European consensus conference on faecal microbiota transplantation in clinical practice. Gut 66:569–580. https://doi.org/10.1136/gutjnl-2016-313017

    Article  PubMed  Google Scholar 

  14. El Hage CN, Ghoneim S, Shah S, Chahine A, Mourad FH, Francis FF, Binion DG, Farraye FA, Hashash JG (2022) Efficacy of fecal microbiota transplantation in the treatment of active ulcerative colitis: a systematic review and meta-analysis of double-blind randomized controlled trials. Inflamm Bowel Dis. https://doi.org/10.1093/ibd/izac135

    Article  Google Scholar 

  15. Paramsothy S, Paramsothy R, Rubin DT, Kamm MA, Kaakoush NO, Mitchell HM, Castaño-Rodríguez N (2017) Faecal microbiota transplantation for inflammatory bowel disease: a systematic review and meta-analysis. J Crohns Colitis 11:1180–1199. https://doi.org/10.1093/ecco-jcc/jjx063

    Article  PubMed  Google Scholar 

  16. Caldeira LdF, Borba HH, Tonin FS, Wiens A, Fernandez-Llimos F, Pontarolo R (2020) Fecal microbiota transplantation in inflammatory bowel disease patients: a systematic review and meta-analysis. PLoS One 15:e0238910. https://doi.org/10.1371/journal.pone.0238910

  17. Colman RJ, Rubin DT (2014) Fecal microbiota transplantation as therapy for inflammatory bowel disease: a systematic review and meta-analysis. J Crohns Colitis 8:1569–1581. https://doi.org/10.1016/j.crohns.2014.08.006

    Article  PubMed  Google Scholar 

  18. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, Chou R, Glanville J, Grimshaw JM, Hróbjartsson A, Lalu MM, Li T, Loder EW, Mayo-Wilson E, McDonald S, McGuinness LA, Stewart LA, Thomas J, Tricco AC, Welch VA, Whiting P, Moher D (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71. https://doi.org/10.1136/bmj.n71

  19. Higgins JPT, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD, Savovic J, Schulz KF, Weeks L, Sterne JAC (2011) The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ 343:d5928. https://doi.org/10.1136/bmj.d5928

  20. Suskind DL, Brittnacher MJ, Wahbeh G, Shaffer ML, Hayden HS, Qin X, Singh N, Damman CJ, Hager KR, Nielson H, Miller SI (2015) Fecal microbial transplant effect on clinical outcomes and fecal microbiome in active Crohn’s disease. Inflamm Bowel Dis 21:556–563. https://doi.org/10.1097/MIB.0000000000000307

    Article  PubMed  Google Scholar 

  21. Gutin L, Piceno Y, Fadrosh D, Lynch K, Zydek M, Kassam Z, LaMere B, Terdiman J, Ma A, Somsouk M, Lynch S, El-Nachef N (2019) Fecal microbiota transplant for Crohn disease: a study evaluating safety, efficacy, and microbiome profile. United European Gastroenterol J 7:807–814. https://doi.org/10.1177/2050640619845986

    Article  PubMed  PubMed Central  Google Scholar 

  22. Xiang L, Ding X, Li Q, Wu X, Dai M, Long C, He Z, Cui B, Zhang F (2020) Efficacy of faecal microbiota transplantation in Crohn’s disease: a new target treatment? Microb Biotechnol 13:760–769. https://doi.org/10.1111/1751-7915.13536

    Article  PubMed  PubMed Central  Google Scholar 

  23. Higgins JPT, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21:1539–1558. https://doi.org/10.1002/sim.1186

    Article  PubMed  Google Scholar 

  24. Vermeire S, Joossens M, Verbeke K, Wang J, Machiels K, Sabino J, Ferrante M, Van Assche G, Rutgeerts P, Raes J (2016) Donor species richness determines faecal microbiota transplantation success in inflammatory bowel disease. J Crohns Colitis 10:387–394. https://doi.org/10.1093/ecco-jcc/jjv203

    Article  PubMed  Google Scholar 

  25. Wei Y, Zhu W, Gong J, Guo D, Gu L, Li N, Li J (2015) Fecal microbiota transplantation improves the quality of life in patients with inflammatory bowel disease. Gastroenterol Res Pract 2015:517597. https://doi.org/10.1155/2015/517597

  26. Goyal A, Yeh A, Bush BR, Firek BA, Siebold LM, Rogers MB, Kufen AD, Morowitz MJ (2018) Safety, clinical response, and microbiome findings following fecal microbiota transplant in children with inflammatory bowel disease. Inflamm Bowel Dis 24:410–421. https://doi.org/10.1093/ibd/izx035

    Article  PubMed  Google Scholar 

  27. Yang Z, Bu C, Yuan W, Shen Z, Quan Y, Wu S, Zhu C, Wang X (2020) Fecal microbiota transplant via endoscopic delivering through small intestine and colon: no difference for Crohn’s disease. Dig Dis Sci 65:150–157. https://doi.org/10.1007/s10620-019-05751-y

    Article  PubMed  Google Scholar 

  28. Wang H, Cui B, Li Q, Ding X, Li P, Zhang T, Yang X, Ji G, Zhang F (2018) The safety of fecal microbiota transplantation for Crohn’s disease: findings from a long-term study. Adv Ther 35:1935–1944. https://doi.org/10.1007/s12325-018-0800-3

    Article  PubMed  PubMed Central  Google Scholar 

  29. Karolewska-Bochenek K, Grzesiowski P, Banaszkiewicz A, Gawronska A, Kotowska M, Dziekiewicz M, Albrecht P, Radzikowski A, Lazowska-Przeorek I (2018) A two-week fecal microbiota transplantation course in pediatric patients with inflammatory bowel disease. Adv Exp Med Biol 1047:81–87. https://doi.org/10.1007/5584_2017_123

    Article  CAS  PubMed  Google Scholar 

  30. Li N, Tian H, Ma C, Ding C, Ge X, Gu L, Zhang X, Yang B, Hua Y, Zhu Y, Zhou Y (2017) Efficacy analysis of fecal microbiota transplantation in the treatment of 406 cases with gastrointestinal disorders. Zhonghua Wei Chang Wai Ke Za Zhi 20:40–46

    CAS  PubMed  Google Scholar 

  31. He Z, Li P, Zhu J, Cui B, Xu L, Xiang J, Zhang T, Long C, Huang G, Ji G, Nie Y, Wu K, Fan D, Zhang F (2017) Multiple fresh fecal microbiota transplants induces and maintains clinical remission in Crohn’s disease complicated with inflammatory mass. Sci Rep 7:4753. https://doi.org/10.1038/s41598-017-04984-z

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Cui B, Feng Q, Wang H, Wang M, Peng Z, Li P, Huang G, Liu Z, Wu P, Fan Z, Ji G, Wang X, Wu K, Fan D, Zhang F (2015) Fecal microbiota transplantation through mid-gut for refractory Crohn’s disease: safety, feasibility, and efficacy trial results. J Gastroenterol Hepatol 30:51–58. https://doi.org/10.1111/jgh.12727

    Article  CAS  PubMed  Google Scholar 

  33. Zou M, Jie Z, Cui B, Wang H, Feng Q, Zou Y, Zhang X, Yang H, Wang J, Zhang F, Jia H (2020) Fecal microbiota transplantation results in bacterial strain displacement in patients with inflammatory bowel diseases. FEBS Open Bio 10:41–55. https://doi.org/10.1002/2211-5463.12744

    Article  CAS  PubMed  Google Scholar 

  34. Takahashi K, Nishida A, Fujimoto T, Fujii M, Shioya M, Imaeda H, Inatomi O, Bamba S, Sugimoto M, Andoh A (2016) Reduced abundance of butyrate-producing bacteria species in the fecal microbial community in Crohn’s disease. Digestion 93:59–65. https://doi.org/10.1159/000441768

    Article  CAS  PubMed  Google Scholar 

  35. Yu Y, Yang W, Li Y, Cong Y (2020) Enteroendocrine cells: sensing gut microbiota and regulating inflammatory bowel diseases. Inflamm Bowel Dis 26:11–20. https://doi.org/10.1093/ibd/izz217

    Article  PubMed  Google Scholar 

  36. Kao D, Hotte N, Gillevet P, Madsen K (2014) Fecal microbiota transplantation inducing remission in Crohn’s colitis and the associated changes in fecal microbial profile. J Clin Gastroenterol 48:625–628. https://doi.org/10.1097/MCG.0000000000000131

    Article  PubMed  Google Scholar 

  37. Sokol H, Landman C, Seksik P, Berard L, Montil M, Nion-Larmurier I, Bourrier A, Le Gall G, Lalande V, De Rougemont A, Kirchgesner J, Daguenel A, Cachanado M, Rousseau A, Drouet É, Rosenzwajg M, Hagege H, Dray X, Klatzman D, Marteau P, Beaugerie L, Simon T (2020) Fecal microbiota transplantation to maintain remission in Crohn’s disease: a pilot randomized controlled study. Microbiome 8:12. https://doi.org/10.1186/s40168-020-0792-5

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Park J, Kim M, Kang SG, Jannasch AH, Cooper B, Patterson J, Kim CH (2015) Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6K pathway. Mucosal Immunol 8:80–93. https://doi.org/10.1038/mi.2014.44

    Article  CAS  PubMed  Google Scholar 

  39. Costello S, Waters O, Bryant R, Katsikeros R, Makanyanga J, Schoeman M, Mountifield R, Tee D, Howell S, Hughes P, Conlon M, Roberts-Thomson I, Andrews J (2017) Short duration, low intensity pooled faecal microbiota transplantation induces remission in patients with mild-moderately active ulcerative colitis: a randomised controlled trial. J Crohns Colitis 11:S23–S23

    Article  Google Scholar 

  40. Rossen NG, Fuentes S, van der Spek MJ, Tijssen JG, Hartman JHA, Duflou A, Löwenberg M, van den Brink GR, Mathus-Vliegen EMH, de Vos WM, Zoetendal EG, D'Haens GR, Ponsioen CY (2015) Findings from a randomized controlled trial of fecal transplantation for patients with ulcerative colitis. Gastroenterology 149. https://doi.org/10.1053/j.gastro.2015.03.045

  41. Moayyedi P, Surette MG, Kim PT, Libertucci J, Wolfe M, Onischi C, Armstrong D, Marshall JK, Kassam Z, Reinisch W, Lee CH (2015) Fecal microbiota transplantation induces remission in patients with active ulcerative colitis in a randomized controlled trial. Gastroenterology 149. https://doi.org/10.1053/j.gastro.2015.04.001

  42. Paramsothy S, Kamm MA, Kaakoush NO, Walsh AJ, van den Bogaerde J, Samuel D, Leong RWL, Connor S, Ng W, Paramsothy R, Xuan W, Lin E, Mitchell HM, Borody TJ (2017) Multidonor intensive faecal microbiota transplantation for active ulcerative colitis: a randomised placebo-controlled trial. Lancet 389:1218–1228. https://doi.org/10.1016/S0140-6736(17)30182-4

    Article  PubMed  Google Scholar 

  43. Varela E, Manichanh C, Gallart M, Torrejón A, Borruel N, Casellas F, Guarner F, Antolin M (2013) Colonisation by Faecalibacterium prausnitzii and maintenance of clinical remission in patients with ulcerative colitis. Aliment Pharmacol Ther 38:151–161. https://doi.org/10.1111/apt.12365

    Article  CAS  PubMed  Google Scholar 

  44. Jacob V, Crawford C, Cohen-Mekelburg S, Viladomiu M, Putzel GG, Schneider Y, Chabouni F, OʼNeil S, Bosworth B, Woo V, Ajami NJ, Petrosino JF, Gerardin Y, Kassam Z, Smith M, Iliev ID, Sonnenberg GF, Artis D, Scherl E, Longman RS (2017) Single delivery of high-diversity fecal microbiota preparation by colonoscopy is safe and effective in increasing microbial diversity in active ulcerative colitis. Inflamm Bowel Dis 23:903–911. https://doi.org/10.1097/MIB.0000000000001132

    Article  PubMed  Google Scholar 

  45. Levy AN, Allegretti JR (2019) Insights into the role of fecal microbiota transplantation for the treatment of inflammatory bowel disease. Therap Adv Gastroenterol 12:1756284819836893. https://doi.org/10.1177/1756284819836893

    Article  PubMed  PubMed Central  Google Scholar 

  46. Bahl MI, Bergström A, Licht TR (2012) Freezing fecal samples prior to DNA extraction affects the Firmicutes to Bacteroidetes ratio determined by downstream quantitative PCR analysis. FEMS Microbiol Lett 329:193–197. https://doi.org/10.1111/j.1574-6968.2012.02523.x

    Article  CAS  PubMed  Google Scholar 

  47. Cammarota G, Ianiro G, Gasbarrini A (2014) Fecal microbiota transplantation for the treatment of Clostridium difficile infection: a systematic review. J Clin Gastroenterol 48:693–702. https://doi.org/10.1097/MCG.0000000000000046

    Article  PubMed  Google Scholar 

  48. Hamilton MJ, Weingarden AR, Sadowsky MJ, Khoruts A (2012) Standardized frozen preparation for transplantation of fecal microbiota for recurrent Clostridium difficile infection. Am J Gastroenterol 107:761–767. https://doi.org/10.1038/ajg.2011.482

    Article  PubMed  Google Scholar 

  49. Youngster I, Russell GH, Pindar C, Ziv-Baran T, Sauk J, Hohmann EL (2014) Oral, capsulized, frozen fecal microbiota transplantation for relapsing Clostridium difficile infection. JAMA 312:1772–1778. https://doi.org/10.1001/jama.2014.13875

    Article  CAS  PubMed  Google Scholar 

  50. Gough E, Shaikh H, Manges AR (2011) Systematic review of intestinal microbiota transplantation (fecal bacteriotherapy) for recurrent Clostridium difficile infection. Clin Infect Dis 53:994–1002. https://doi.org/10.1093/cid/cir632

    Article  PubMed  Google Scholar 

  51. Haifer C, Paramsothy S, Kaakoush NO, Saikal A, Ghaly S, Yang T, Luu LDW, Borody TJ, Leong RW (2022) Lyophilised oral faecal microbiota transplantation for ulcerative colitis (LOTUS): a randomised, double-blind, placebo-controlled trial. Lancet Gastroenterol Hepatol 7:141–151. https://doi.org/10.1016/S2468-1253(21)00400-3

    Article  PubMed  Google Scholar 

  52. Kassam Z, Lee CH, Yuan Y, Hunt RH (2013) Fecal microbiota transplantation for Clostridium difficile infection: systematic review and meta-analysis. Am J Gastroenterol 108:500–508. https://doi.org/10.1038/ajg.2013.59

    Article  PubMed  Google Scholar 

  53. Ianiro G, Maida M, Burisch J, Simonelli C, Hold G, Ventimiglia M, Gasbarrini A, Cammarota G (2018) Efficacy of different faecal microbiota transplantation protocols for infection: a systematic review and meta-analysis. United European Gastroenterol J 6:1232–1244. https://doi.org/10.1177/2050640618780762

    Article  PubMed  PubMed Central  Google Scholar 

  54. Hui W, Li T, Liu W, Zhou C, Gao F (2019) Fecal microbiota transplantation for treatment of recurrent C. difficile infection: an updated randomized controlled trial meta-analysis. PLoS One 14:e0210016. https://doi.org/10.1371/journal.pone.0210016

  55. Costello SP, Hughes PA, Waters O, Bryant RV, Vincent AD, Blatchford P, Katsikeros R, Makanyanga J, Campaniello MA, Mavrangelos C, Rosewarne CP, Bickley C, Peters C, Schoeman MN, Conlon MA, Roberts-Thomson IC, Andrews JM (2019) Effect of fecal microbiota transplantation on 8-week remission in patients with ulcerative colitis: a randomized clinical trial. JAMA 321:156–164. https://doi.org/10.1001/jama.2018.20046

    Article  PubMed  PubMed Central  Google Scholar 

  56. Pai N, Popov J, Hill L, Hartung E, Grzywacz K, Moayyedi P (2021) Results of the first pilot randomized controlled trial of fecal microbiota transplant in pediatric ulcerative colitis: lessons, limitations, and future prospects. Gastroenterology 161. https://doi.org/10.1053/j.gastro.2021.04.067

  57. Hedin C, van der Gast CJ, Rogers GB, Cuthbertson L, McCartney S, Stagg AJ, Lindsay JO, Whelan K (2016) Siblings of patients with Crohn’s disease exhibit a biologically relevant dysbiosis in mucosal microbial metacommunities. Gut 65:944–953. https://doi.org/10.1136/gutjnl-2014-308896

    Article  CAS  PubMed  Google Scholar 

  58. Hoffmann DE, Palumbo FB, Ravel J, Rowthorn V, von Rosenvinge E (2017) A proposed definition of microbiota transplantation for regulatory purposes. Gut Microbes 8:208–213. https://doi.org/10.1080/19490976.2017.1293223

    Article  PubMed  PubMed Central  Google Scholar 

  59. Zhang T, Lu G, Zhao Z, Liu Y, Shen Q, Li P, Chen Y, Yin H, Wang H, Marcella C, Cui B, Cheng L, Ji G, Zhang F (2020) Washed microbiota transplantation vs. manual fecal microbiota transplantation: clinical findings, animal studies and in vitro screening. Protein Cell 11:251–266. https://doi.org/10.1007/s13238-019-00684-8

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Funding

This study was supported by CNS-ZD Tizhi and Health Fund (CNS-ZD2020-21) and Key Research and Development Project of Hubei Province (2020BCA081-03).

Author information

Authors and Affiliations

  1. College of Marine Science and Biological Engineering, Qingdao University of Science and Technology, Qingdao, 266000, People’s Republic of China

    Siyu Zhou, Yun Zhang, Tianyu Zhao & Jing Cong

  2. Department of Oncology, Affiliated Qingdao Central Hospital of Qingdao University, Qingdao Cancer Hospital, Siliu South Road No.127, Qingdao, 266000, People’s Republic of China

    Ying Cui

Authors
  1. Siyu Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ying Cui
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yun Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Tianyu Zhao
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jing Cong
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

The following authors’ contributions are acknowledged: Siyu Zhou: literature search, data collection, data analysis, manuscript writing, and editing; Ying Cui: literature search, data collection, and data analysis; Yun Zhang, Tianyu Zhao: critical revision of the manuscript; and Jing Cong: project development, manuscript revision, and proofreading. All authors discussed the results and contributed to writing and proofreading the final manuscript. All authors approved the final version of the manuscript.

Corresponding author

Correspondence to Jing Cong.

Ethics declarations

Conflict of interest

The authors declare no competing interests.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary Information

Below is the link to the electronic supplementary material.

Supplementary file1 (DOCX 3492 KB)

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zhou, S., Cui, Y., Zhang, Y. et al. Fecal microbiota transplantation for induction of remission in Crohn’s disease: a systematic review and meta-analysis. Int J Colorectal Dis 38, 62 (2023). https://doi.org/10.1007/s00384-023-04354-4

Download citation

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s00384-023-04354-4

Keywords

Search

Navigation