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Comparison of nutritional and immunological scoring systems predicting prognosis in T1-2N0 colorectal cancer

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Purpose

Previous studies have shown that the new nutritional and immunological status scoring systems of the Naples prognostic score (NPS), controlling nutritional status score (CONUT), and the older prognostic nutritional index (PNI) are independent predictors in colorectal cancer. This study compares the prognostic value of NPS, CONUT, and PNI in T1–2N0 colorectal cancer.

Methods

We retrospectively evaluated 305 consecutive stage I (T1-2N0M0) colorectal cancer patients who underwent radical surgery from January 2010 to December 2015 at our hospital. The NPS results were divided into 3 groups (0, 1, and 2 groups), and the PNI and CONUT results were divided into 2 groups (low and high groups).

Results

The patients with low PNI had worse overall survival (OS) and disease-free survival (DFS) than those with high PNI (P < 0.001 and P < 0.001, respectively). Multivariate analysis showed that PNI was independently associated with OS and DFS (P < 0.001 and P < 0.001, respectively), but NPS and CONUT results were not.

Conclusion

The PNI is an independent predictor in stage I colorectal cancer, but NPS and CONUT results are not.

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Data availability

The dataset of the current study is available from the corresponding author on reasonable request.

Code availability

Not applicable.

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Authors and Affiliations

  1. Department of Surgery, Ajou University School of Medicine, 164, World cup-ro, Yeongtong-gu, Suwon, 16499, Korea

    Guangzhe Pian & Seung Yeop Oh

  2. Department of Surgery, Ajou University Graduate School of Medicine, Suwon, Korea

    Guangzhe Pian

  3. Department of Surgery, Yanbian University Hospital, Jilin, China

    Guangzhe Pian

Authors
  1. Guangzhe Pian
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  2. Seung Yeop Oh
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Contributions

Seung Yeop Oh contributed to the design of this paper, analysis of data, revising this paper, and final approval. Guangzhe Pian contributed to the design of this paper, analysis of data, revising this pater, and final approval.

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Correspondence to Seung Yeop Oh.

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This study had full ethical approval from the Institutional Review Board of Ajou University School of Medicine.

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The authors declare no competing interests.

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Pian, G., Oh, S.Y. Comparison of nutritional and immunological scoring systems predicting prognosis in T1-2N0 colorectal cancer. Int J Colorectal Dis 37, 179–188 (2022). https://doi.org/10.1007/s00384-021-04043-0

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