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Rates of inflammatory bowel disease in Hispanics comparable to non-Hispanic Whites: results of a cohort study

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Purpose

Previous studies have suggested that inflammatory bowel disease (IBD) occurs at higher rates among non-Hispanic Whites (NHWs) compared to other ethnicities; however, Hispanics as the largest minority in the United States remain underrepresented in IBD research and we hypothesize that they have similar rates of IBD. We examined the epidemiology, demographics, clinical presentation, and treatment of IBD in a predominantly Hispanic cohort in Los Angeles (LA) County.

Methods

This was a retrospective cohort study based at Olive View-UCLA Medical Center, one of the three major safety-net hospitals in LA County. Electronic medical records from 2015 to 2018 were queried, and biopsy-proven cases of IBD (n = 170) were identified. Outcomes included the incidence and prevalence of IBD, disease distribution, treatment, and IBD-related surgery.

Results

The incidence of IBD among Hispanics was 175 (95% confidence interval [CI] 127–240) and 113 (95% CI 62–200) for NHWs per 100,000 person-years. Prevalence of IBD per 100,000 people was 418 (95% CI 341–512) for Hispanics and 557 (95% CI 431–739) for NHWs. Notably, the proportion of Hispanic IBD patients with a history of smoking was 21.5% vs 50.8% in NHWs (p = 0.011). There were no significant differences between the two groups with regard to Montreal classification, pharmacotherapy, or IBD-related surgery.

Conclusions

In one of the largest US studies of Hispanics with IBD, and the only one to have both clinical and histopathologic confirmation as inclusion criteria, we found the incidence and prevalence of IBD among Hispanics to be higher than previously recognized and comparable to NHWs. Additionally, Hispanic IBD patients had lower rates of smoking compared to NHWs.

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Data availability

Data is available upon request of corresponding author

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Author information

Authors and Affiliations

  1. Department of Internal Medicine, Santa Monica UCLA Medical Center, Santa Monica, CA, 90404, USA

    Alex Zhornitskiy

  2. Department of Gastroenterology and Hepatology, University of Vermont Medical Center, Burlington, VT, USA

    Stacy Shen

  3. Department of Medicine, Olive View-UCLA Medical Center, Sylmar, CA, USA

    Long B. Le

  4. Department of Medicine, University of Arizona College of Medicine-Phoenix, Phoenix, AZ, USA

    Brian M. Fung

  5. Department of Public Health, University of California, Berkeley, Berkeley, CA, USA

    Felicia Zhornitsky

  6. Department of Pathology, LAC-USC Medical Center, Los Angeles, CA, USA

    Tom Liang & Jenny S. Sauk

  7. The Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA

    Berkeley N. Limketkai & James H. Tabibian

  8. Division of Gastroenterology, Department of Medicine, Olive View-UCLA Medical Center, Sylmar, CA, USA

    James H. Tabibian

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  1. Alex Zhornitskiy
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Contributions

AZ, SS, TL, and BMF acquired the data. AZ, LBL, and FZ performed the data and statistical analyses. AZ and SS wrote the first draft with additions/edits from LBL, BMF, and FZ. Supervision and critical revision of the manuscript were provided by BNL, JSS, and JHT.

Corresponding author

Correspondence to Alex Zhornitskiy.

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Conflict of interest

As part of disclosures JSS notes consulting (Corrona LLC), speaker’s bureau (Pfizer/Abbvie), and participation in advisory board (Prometheus Biosciences LLC). AZ, SS, LBL, BMF, FZ, BNL, and JHT have no relevant disclosures to declare.

Ethics approval

This study is approved by the Olive-View UCLA IRB.

Consent to participate

None required per IRB as this was a retrospective study, with no subjects contacted, and all information medical information de-identified

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Consent for publication is given by all authors.

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Not applicable.

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Zhornitskiy, A., Shen, S., Le, L.B. et al. Rates of inflammatory bowel disease in Hispanics comparable to non-Hispanic Whites: results of a cohort study. Int J Colorectal Dis 36, 1043–1051 (2021). https://doi.org/10.1007/s00384-020-03819-0

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