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Colonic diverticular disease in autosomal dominant polycystic kidney disease: is there really an association? A nationwide analysis

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Purpose

Colonic diverticulosis, diverticulitis, and diverticular bleeding are reportedly more common in patients with autosomal dominant polycystic kidney disease (ADPKD). Other studies have questioned this association. The objectives of our study are to clarify this association using a larger patient population and to identify risk factors in general to develop diverticular disease.

Methods

The Nationwide Inpatient Sample weighted discharges from 2003 to 2011 were used to assess for the prevalence of diverticular disease in the population with ADPKD compared with the general population without ADPKD. A multivariable direct logistic regression model was constructed to determine independent predictors of diverticular disease in the general population.

Results

The prevalence of diverticulosis, diverticulitis, and diverticular bleeding were considerably increased in patients with ADPKD compared with the general population without ADPKD. The prevalence of colonic surgery was less in ADPKD patients with diverticulitis. In patients with kidney transplant, the prevalence of diverticulitis was increased in the ADPKD group, but colonic surgery was not significantly different between both groups. The prevalence of diverticular bleeding was slightly elevated in patients with ADPKD, but colonic surgery was significantly increased in patients with ADPKD. NSAID use, hypertension, constipation, and ADPKD had increased odds ratios for diverticular disease during multivariate analysis.

Conclusion

There is an increased prevalence of colonic diverticular disease in the population with ADPKD.

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Authors and Affiliations

  1. Department of Internal Medicine, Division of Gastroenterology, St. Luke’s University Health Network, 801 Ostrum Street, Bethlehem, PA, 18015, USA

    Rodrigo Duarte-Chavez, Noel Martins, Berhanu Geme & Yecheskel Schneider

  2. Department of Research, St. Luke’s University Health Network, 801 Ostrum Street, Bethlehem, PA, 18015, USA

    Jill Stoltzfus & Vikas Yellapu

  3. Department of Internal Medicine, Division of Cardiology, St. Luke’s University Health Network, 801 Ostrum Street, Bethlehem, PA, 18015, USA

    Sudip Nanda

  4. Department of Pathology, St. Luke’s University Health Network, 801 Ostrum Street, Bethlehem, PA, 18015, USA

    Santo Longo

Authors
  1. Rodrigo Duarte-Chavez
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  2. Jill Stoltzfus
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  3. Vikas Yellapu
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  4. Noel Martins
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  5. Sudip Nanda
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  6. Santo Longo
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  7. Berhanu Geme
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  8. Yecheskel Schneider
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Rodrigo Duarte-Chavez, Jill Stoltzfus, Vikas Yellapu, Noel Martins, Sudip Nanda, Santo Longo, Berhanu Geme, and Yecheskel Schneider. The first draft of the manuscript was written by Rodrigo Duarte-Chavez, and all authors commented on the previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Rodrigo Duarte-Chavez.

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The authors declare that they have no conflict of interest.

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This research study was conducted retrospectively from data obtained for clinical purposes. We consulted extensively with the IRB of St Luke’s University Health Network who determined that our study did not need ethical approval. An IRB official waiver of ethical approval was granted from the IRB of St Luke’s University Health Network.

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Duarte-Chavez, R., Stoltzfus, J., Yellapu, V. et al. Colonic diverticular disease in autosomal dominant polycystic kidney disease: is there really an association? A nationwide analysis. Int J Colorectal Dis 36, 83–91 (2021). https://doi.org/10.1007/s00384-020-03736-2

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