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Traditional serrated adenomas (TSA) and the company they keep: TSA presence predicts advanced neoplasm states

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Abstract

Background

The association of TSAs with metachronous neoplasms is well established and suggests that TSAs would also have an association with synchronous neoplasms.

Methods

We compared odds ratios and rates of synchronous neoplasms found in colonoscopies with and without TSAs.

Results

There was a mean of 2.44 neoplasms among TSA cases in comparison with 1.72 in non-TSA cases. The odds ratio for advanced neoplasia was highest among cases with one or more TSAs relative to cases with one or more HPs (7.54 [CI, 4.23–13.44]) when compared with adenomas (1.95 [CI, 1.75–2.17]) and SSPs (2.98 [CI, 2.54–3.5]).

Conclusions

In this study population, there is a 7-fold higher risk of synchronous advanced neoplasms among cases with one or more TSAs.

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Fig. 1

Data availability

Yes

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Author information

Authors and Affiliations

  1. Department of Internal Medicine, University of California Irvine Medical Center, 101 The City Drive, City Tower, Suite 400, Orange, CA, 92806, USA

    Erica Duh

  2. Department of Gastroenterology, University of California Irvine Medical Center, Orange, CA, USA

    Piotr Sowa & William Karnes

  3. Statistical Programmer, Brown University Center for Primary Care and Prevention, Pawtucket, RI, USA

    Mary B. Roberts

Authors
  1. Erica Duh
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  2. Piotr Sowa
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  3. Mary B. Roberts
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  4. William Karnes
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Contributions

Study design, planning, and conduct: ED, PS, WK. Data collection: PS, WK. Data interpretation: MR, WK. Manuscript preparation: ED, PS, WK. Manuscript revision and editing: ED, PS, WK. All authors have viewed and approved the final draft of this manuscript.

Corresponding author

Correspondence to Erica Duh.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Ethics

The research dataset is exempt from human-subjects research for IRB purposes as determined by the University of California, Irvine (UCI) Human Research Protections Program (HS#2015–1939 [eAPP# 8814] dated 1/13/2016).

Guarantor

William Karnes, MD

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Study highlights

What is known

• TSAs are associated with metachronous colorectal advanced neoplasms.

What is new here

• TSAs are associated with synchronous precancerous and advanced neoplasms. Our data contributes to existing data supporting a strong link between TSA and risk of current and future advanced neoplasms. We aim to add to the already existing efforts to elucidate the biological genesis of TSAs and to support adjustments of guideline surveillance recommendations for patients with TSAs.

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Cite this article

Duh, E., Sowa, P., Roberts, M.B. et al. Traditional serrated adenomas (TSA) and the company they keep: TSA presence predicts advanced neoplasm states. Int J Colorectal Dis 35, 1351–1354 (2020). https://doi.org/10.1007/s00384-020-03587-x

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  • DOI: https://doi.org/10.1007/s00384-020-03587-x

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