Skip to main content

Advertisement

SpringerLink
Log in

Colorectal cancer in the setting of pregnancy and familial risk

  • Original Article
  • Published:
International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Background and aims

Women are at risk of colorectal cancer (CRC) during pregnancy but this fact is underappreciated. We performed a population-based study to evaluate the rate, predictors, and familial risk for pregnancy associated CRC in Utah.

Methods

All newly diagnosed cases of CRC between 1973 and 2014 were obtained from the Utah Cancer Registry and linked to pedigrees from the Utah Population Database.

Results

Of the 12,886 females diagnosed with CRC, 73 were diagnosed with CRC (0.57%) during the period of obstetric delivery/childbirth. Pregnancy associated CRC was diagnosed at a mean age of 31.9 years, and cancers were less frequently located in the proximal colon compared with women with non-pregnancy associated CRC. First-degree relatives of cases with pregnancy associated CRC had a nearly threefold higher risk of CRC (OR, 2.76; 95% CI, 1.26–6.01) compared with relatives of CRC-free individuals.

Conclusions

Of women diagnosed with CRC, less than 1% were diagnosed during or soon after obstetric delivery/childbirth. Relatives of these patients have a nearly threefold greater risk of CRC than those without a family history of CRC. These results provide physicians with data to guide the care of patients and their relatives with pregnancy associated CRC.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Smith LH, Danielsen B, Allen ME, Cress R (2003) Cancer associated with obstetric delivery: results of linkage with the California Cancer Registry. Am J Obstet Gynecol 189:1128–1135

    Article  Google Scholar 

  2. Chan YM, Ngai SW, Lao TT (1999) Colon cancer in pregnancy. A case report. J Reprod Med 44:733–736

    CAS  PubMed  Google Scholar 

  3. Hojgaard HM, Rahr H (2012) Rectal cancer in a pregnant woman, a case report. Ugeskr Laeger 174:1827–1828

    PubMed  Google Scholar 

  4. Grass F, Spindler BA, Naik ND, Thiels CA, Dozois EJ, Larson DW, Mathis KL (2019) Oncological outcome of peripartum colorectal carcinoma-a single-center experience. Int J Color Dis 34:899–904

    Article  Google Scholar 

  5. Kanth P, Grimmett J, Champine M, Burt R, Samadder NJ (2017) Hereditary colorectal polyposis and cancer syndromes: a primer on diagnosis and management. Am J Gastroenterol 112:1509–1525

    Article  Google Scholar 

  6. Jorde LB (1989) Inbreeding in the Utah Mormons: an evaluation of estimates based on pedigrees, isonymy, and migration matrices. Ann Hum Genet 53:339–355

    Article  CAS  Google Scholar 

  7. Guthery SL, Mineau G, Pimentel R, Williams MS, Kerber RA (2011) Inflammatory bowel disease aggregation in Utah kindreds. Inflamm Bowel Dis 17:823–830

    Article  Google Scholar 

  8. Kerber RA (1995) Method for calculating risk associated with family history of a disease. Genet Epidemiol 12:291–301

    Article  CAS  Google Scholar 

  9. Pellino G, Simillis C, Kontovounisios C, Baird DL, Nikolaou S, Warren O, Tekkis PP, Rasheed S (2017) Colorectal cancer diagnosed during pregnancy: systematic review and treatment pathways. Eur J Gastroenterol Hepatol 29:743–753

    Article  Google Scholar 

  10. Kocian P, de Haan J, Cardonick EH et al (2019) Management and outcome of colorectal cancer during pregnancy: report of 41 cases. Acta Chir Belg 119:166–175

    Article  CAS  Google Scholar 

  11. Dahling MT, Xing G, Cress R, Danielsen B, Smith LH (2009) Pregnancy-associated colon and rectal cancer: perinatal and cancer outcomes. J Matern Fetal Neonatal Med 22:204–211

    Article  Google Scholar 

  12. Willauer AN, Liu Y, Pereira AAL, Lam M, Morris JS, Raghav KPS, Morris VK, Menter D, Broaddus R, Meric-Bernstam F, Hayes-Jordan A, Huh W, Overman MJ, Kopetz S, Loree JM (2019) Clinical and molecular characterization of early-onset colorectal cancer. Cancer 125(12):2002–2010

  13. Burt R (2013) Colonoscopy was widely available in Utah since 1980

Download references

Funding

The study was funded by the National Cancer Institute, American College of Gastroenterology, American Society for Gastrointestinal Endoscopy, and the Huntsman Cancer Foundation. The funding source did not play a role in the design, conduct, or reporting of the study or in the decision to submit the manuscript for publication.

Support for this project was provided by NCI grants P01-CA073992 (RWB), R01-CA040641 (RWB), an Endoscopic Research Award from the American Society for Gastrointestinal Endoscopy (NJS) and a Junior Faculty Career Development Award from the American College of Gastroenterology (NJS). Partial support for the Utah Population Database and this project was provided by the Huntsman Cancer Institute Cancer Center Support Grant P30CA042014 from the National Cancer institute and the Huntsman Cancer Foundation. Support for the Utah Cancer Registry is provided by Contract #HHSN 261201000026C from the National Cancer Institute with additional support from the Utah Department of Health and the University of Utah.

Author information

Authors and Affiliations

  1. Huntsman Cancer Institute, Salt Lake City, UT, USA

    N. Jewel Samadder, Ken Robert Smith, Jathine Wong, Randall W. Burt & Karen Curtin

  2. Department of Medicine (Gastroenterology), University of Utah, Salt Lake City, UT, USA

    N. Jewel Samadder & Randall W. Burt

  3. Mayo Clinic, Division of Gastroenterology and Hepatology, Department of Clinical Genomics, 5777 East Mayo Boulevard, Phoenix, AR, 85054, USA

    N. Jewel Samadder

  4. Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA

    Randall W. Burt

  5. Department of Medicine (Genetic Epidemiology), University of Utah, Salt Lake City, UT, USA

    Karen Curtin

Authors
  1. N. Jewel Samadder
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ken Robert Smith
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jathine Wong
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Randall W. Burt
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Karen Curtin
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

Drs. Samadder and Curtin had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analyses. Study concept and design (RWB, KC, NJS); acquisition, analysis, and interpretation of data (KC, JW, KS); drafting of the manuscript (KC and NJS); critical revision of the manuscript for important intellectual content (KC, RWB, KS); statistical analysis (JW, KC); obtained funding (NJS and RWB).

Corresponding author

Correspondence to N. Jewel Samadder.

Ethics declarations

Conflict of interest

RWB is a consultant for Myriad Genetics and NJS is a consultant for Cancer Prevention Pharmaceuticals and Janssen Research and Development. No other authors have a conflict of interest to disclose.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Samadder, N.J., Smith, K.R., Wong, J. et al. Colorectal cancer in the setting of pregnancy and familial risk. Int J Colorectal Dis 35, 1559–1566 (2020). https://doi.org/10.1007/s00384-020-03579-x

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00384-020-03579-x

Keywords

Search

Navigation