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Ileal pouch–anal anastomosis in ulcerative colitis: outcomes, functional results, and quality of life in patients with more than 10-year follow-up

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Abstract

Purpose

Ileal pouch–anal anastomosis (IPAA) has become the surgical procedure of choice for patients with ulcerative colitis (UC). IPAA was incorporated into our institution in 1984, and thereafter, more than 200 procedures have been performed. The functional results and morbidity of this surgery have been reported previously. However, long-term functional outcomes and quality of life have not been evaluated.

Methods

As a cohort study, we identified all consecutive patients who underwent IPAA for UC between 1984 and 2017 and selected those with more than 10-year follow-up. Demographic data, morbidity, and pouch survival information were obtained. Long-term functional results and quality of life were evaluated through an e-mail survey using the Öresland score and the Cleveland Global Quality of Life scales, respectively.

Results

Of 201 patients, 116 met the inclusion criteria. Median follow-up was 20 (10–34) years. Early post-operative complications (30 days) were observed in 19 (16.4%) patients and 66 (56.9%) presented adverse events. The IPAA preservation rate at 10 and 20 years was 96.5% and 93.1%, respectively. Long-term functional scores presented a median of 6 (1–15) points. IPAA function was satisfactory in 11 (20.0%) patients, acceptable in 18 (32.7%), and deficient in 26 (47.3%). The median score for global quality of life was 0.8 (0.23–1.0) points.

Conclusion

IPAA as treatment for UC meets the expectations of cure of the disease, maintaining adequate long-term intestinal functionality associated with a good quality of life in most patients.

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Funding

This work is supported by Pontificia Universidad Católica.

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Authors and Affiliations

  1. Colorectal Unit, Department of Digestive Surgery, Pontificia Universidad Católica de Chile, Diagonal Paraguay, 362, Santiago, Región Metropolitana, Chile

    L. Carcamo, P. Miranda, A. Zúñiga, E. Alexander, M. E. Molina, G. Urrejola, T. Larach, R. Miguieles & Felipe Bellolio

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  1. L. Carcamo
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  2. P. Miranda
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  3. A. Zúñiga
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  4. E. Alexander
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  5. M. E. Molina
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  7. T. Larach
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  9. Felipe Bellolio
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Correspondence to Felipe Bellolio.

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The study was reviewed and approved by our institutional ethics committee. All patients provided informed consent to participate in the study before answering the questionnaires applied.

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Carcamo, L., Miranda, P., Zúñiga, A. et al. Ileal pouch–anal anastomosis in ulcerative colitis: outcomes, functional results, and quality of life in patients with more than 10-year follow-up. Int J Colorectal Dis 35, 747–753 (2020). https://doi.org/10.1007/s00384-020-03529-7

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