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International Journal of Colorectal Disease

, Volume 34, Issue 6, pp 1069–1078 | Cite as

Systemic inflammatory response predicts oncological outcomes in patients undergoing elective surgery for mismatch repair-deficient colorectal cancer

  • Marta ClimentEmail author
  • Éanna J. Ryan
  • Áine Stakelum
  • Yi Ling Khaw
  • Ben Creavin
  • Angus Lloyd
  • Dalal Alhassan
  • Helen M. Mohan
  • Rory Kennelly
  • Kieran Sheahan
  • Des C. Winter
Original Article

Abstract

Introduction

A variety of inflammatory scoring systems and their prognostic value have been reported in many solid organ cancers. This study aimed to examine the association between the systemic and local inflammatory responses, and oncological outcomes in patients undergoing elective surgery for mismatch repair-deficient (dMMR) phenotype colorectal cancer (CRC).

Materials and methods

Consecutive patients undergoing resection for dMMR CRC were identified from a prospectively maintained database and compared with a cohort of patients with proficient mismatch repair system tumours. Systemic inflammatory response was assessed by the modified Glasgow prognostic score (mGPS), neutrophil–lymphocyte ratio (NLR), platelet–lymphocyte ratio, lymphocyte-monocyte ratio, C-reactive protein/albumin ratio, prognostic index and prognostic nutritional index. Local inflammatory response was defined by the presence of tumour infiltrating lymphocytes, tumour infiltrating neutrophils, plasma cells or macrophages at the invasive front. The inflammatory infiltrate was assessed using the Klintrup–Mäkinen (KM) score.

Results

On univariable analysis, preoperative NLR ≥ 5 (hazard ratio [HR] 2.5; 95% confidence interval [CI] 1.25–5.19; p = 0.007) and mGPS (HR 1.6; 95% CI 1.1–2.6; p = 0.03) predicted worse overall survival, but only NLR was associated with greater recurrence (HR 3.6; 95% CI 1.5–8.8; p = 0.004). Increased local inflammatory response, as measured by KM score (HR 0.31; 95% CI 0.1–0.7; p = 0.009) and the presence of macrophages in the peritumoral infiltrate (HR 0.17; 95% CI 0.07–0.3; p < 0.001), was associated with better outcomes. NLR was the only independent prognostic factor of overall and disease-free survival.

Conclusion

Systemic inflammatory response predicts oncological outcomes in CRC patients, but only NLR has prognostic value in the dMMR group.

Keywords

Colorectal cancer Local inflammatory response Systemic inflammatory response Neutrophil–lymphocyte ratio Prognostic markers Prognostic scores 

Notes

Compliance with ethical standards

This study was approved by St. Vincent’s University Hospital Research and Ethics Committee.

Supplementary material

384_2019_3274_MOESM1_ESM.docx (19.7 mb)
ESM 1 (DOCX 20168 kb)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Marta Climent
    • 1
    Email author
  • Éanna J. Ryan
    • 1
    • 2
  • Áine Stakelum
    • 1
    • 2
  • Yi Ling Khaw
    • 3
  • Ben Creavin
    • 1
    • 2
  • Angus Lloyd
    • 2
  • Dalal Alhassan
    • 2
  • Helen M. Mohan
    • 1
    • 2
  • Rory Kennelly
    • 1
    • 2
  • Kieran Sheahan
    • 3
  • Des C. Winter
    • 1
    • 2
  1. 1.Centre for Colorectal DiseaseSt Vincent’s University HospitalDublin 4Ireland
  2. 2.School of Medicine and Medical ScienceUniversity College DublinDublin 4Ireland
  3. 3.Department of HistopathologySt Vincent’s University HospitalDublin 4Ireland

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