International Journal of Colorectal Disease

, Volume 34, Issue 3, pp 451–457 | Cite as

Surgical outcomes of patients treated with ustekinumab vs. vedolizumab in inflammatory bowel disease: a matched case analysis

  • Matteo Novello
  • Luca Stocchi
  • Stefan Holubar
  • Sherief Shawki
  • Jeremy Lipman
  • Emre Gorgun
  • Tracy Hull
  • Scott R. SteeleEmail author
Original Article



The association between preoperative use of monoclonal antibodies in inflammatory bowel disease (IBD) patients and postoperative complications is controversial, especially for the latest approved biologics, ustekinumab and vedolizumab, where data is limited. We hypothesized that ustekinumab-treated patients would have a similar overall postoperative complication rate as vedolizumab-treated patients. The aim of this study was to compare postoperative complications in patients receiving preoperative ustekinumab vs. vedolizumab.


We queried our IRB-approved prospective database to identify Crohn’s patients who underwent colorectal surgery and pretreatment with ustekinumab or vedolizumab within 12 weeks of surgery. Ustekinumab-treated patients were matched to vedolizumab-treated patients based on sex, age ± 5 years, date of operation ± 3 years, and type of surgery. Paired univariate analysis and conditional logistic regression of the matched pairs were performed. Our primary outcome was the short-term postoperative complication rate. Secondary outcomes included infectious complications, readmission, reoperation, and length of stay.


A total of 103 patients with Crohn’s disease (CD) met the inclusion criteria (mean age 38.7 ± 13.4 years; male 51.2%). Overall, 30 patients received preoperative ustekinumab and 73 vedolizumab. In the univariate analysis, vedolizumab-treated patients had a higher postoperative complication rate (p = 0.009) and ileus rate (p = 0.015). After matching, 26 matched pairs were compared and logistic regression models demonstrated no significant difference in the primary outcome.


For our limited experience, the choice of preoperative biologic treatment between ustekinumab and vedolizumab should not be influenced by fear of surgical complications.


Ustekinumab Vedolizumab Biologics Colorectal surgery Outcomes Morbidity Mortality Comparison 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Matteo Novello
    • 1
  • Luca Stocchi
    • 1
  • Stefan Holubar
    • 1
  • Sherief Shawki
    • 1
  • Jeremy Lipman
    • 1
  • Emre Gorgun
    • 1
  • Tracy Hull
    • 1
  • Scott R. Steele
    • 1
    Email author
  1. 1.Department of Colorectal Surgery, Digestive Disease & Surgery InstituteCleveland ClinicClevelandUSA

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