Abstract
Purpose
Postoperative ileus (POI) is one of the complications that can occur after every surgical procedure including arthroplasty. It can have detrimental consequences for the patient and portrays an economic burden on health care systems. The risk factors for POI after arthroplasty described in the literature are scarce and include hip arthroplasty, male gender and previous abdominal surgery. The purpose of the study was to determine the risk factors for POI after hip and knee arthroplasty.
Methods
A retrospective review of 2760 patients undergoing primary hip and knee arthroplasty was performed. An in-depth analysis of patient history and physical operative and postoperative course was reviewed and statistically analyzed in a univariate and multivariate setting.
Results
Overall incidence of POI was 0.54%. History of myocardial infarction and chronic kidney disease were statistically significant risk factors for developing POI after arthroplasty with values of p = 0.023 and p = 0.004, respectively. Other risk factors included previous abdominal surgery (p < 0.001) and hip arthroplasty (p = 0.026). Age or gender correlations were not observed.
Conclusions
Although postoperative ileus is an uncommon complication after joint arthroplasty, in addition to the known risk factors of male age, hip arthroplasty, and previous abdominal surgery, this study describes two previously unknown risk factors: chronic kidney disease and history of myocardial infarction. Patients with these risk factors should be monitored closely for developing postoperative ileus.
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References
Jauregui JJ, Cherian JJ, Pierce TP, Beaver WB, Issa K, Mont MA (2015) Long-term survivorship and clinical outcomes following total knee arthroplasty. J Arthroplast 30:2164–2166. https://doi.org/10.1016/j.arth.2015.05.052
Learmonth ID, Young C, Rorabeck C (2007) The operation of the century: total hip replacement. Lancet 370:1508–1519. https://doi.org/10.1016/S0140-6736(07)60457-7
Zhan C, Kaczmarek R, Loyo-Berrios N, Sangl J, Bright RA (2007) Incidence and short-term outcomes of primary and revision hip replacement in the United States. J Bone Joint Surg Am 89:526–533. https://doi.org/10.2106/JBJS.F.00952
Livingston EH, Passaro EP (1990) Postoperative ileus. Dig Dis Sci 35:121–132
Huge A, Kreis ME, Jehle EC, Ehrlein HJ, Starlinger M, Becker HD, Zittel TT (1998) A model to investigate postoperative ileus with strain gauge transducers in awake rats. J Surg Res 74:112–118. https://doi.org/10.1006/jsre.1997.5245
Bederman SS, Betsy M, Winiarsky R, Seldes RM, Sharrock NE, Sculco TP (2001) Postoperative ileus in the lower extremity arthroplasty patient. J Arthroplast 16:1066–1070. https://doi.org/10.1054/arth.2001.27675
Parvizi J, Han S-B, Tarity TD, Pulido L, Weinstein M, Rothman RH (2008) Postoperative ileus after total joint arthroplasty. J Arthroplast 23:360–365. https://doi.org/10.1016/j.arth.2007.12.019
Weinstein MA, Keggi JM, Zatorski LE, Keggi KJ (2002) One-stage bilateral total hip arthroplasty in patients > or = 75 years. Orthopedics 25:153–156
Pavone V, Johnson T, Saulog PS, Sculco TP, Bottner F (2004) Perioperative morbidity in bilateral one-stage total knee replacements. Clin Orthop Relat Res 421:155–161
Berend KR, Lombardi AV, Mallory TH, Dodds KL, Adams JB (2004) Ileus following total hip or knee arthroplasty is associated with increased risk of deep venous thrombosis and pulmonary embolism. J Arthroplast 19:82–86
O. Vilz T, Stoffels B, Strassburg C, H. Schild H, C. Kalff J (2017) Ileus in adults. Dtsch Arztebl Int 114:508–518 . doi: 10.3238/arztebl.2017.0508
Tevis SE, Carchman EH, Foley EF, Harms BA, Heise CP, Kennedy GD (2015) Postoperative ileus–more than just prolonged length of stay? J Gastrointest Surg 19:1684–1690. https://doi.org/10.1007/s11605-015-2877-1
Sibia US, Mandelblatt AE, Callanan MA, MacDonald JH, King PJ (2017) Incidence, risk factors, and costs for hospital returns after total joint arthroplasties. J Arthroplast 32:381–385. https://doi.org/10.1016/j.arth.2016.08.003
Barletta JF, Senagore AJ (2014) Reducing the burden of postoperative ileus: evaluating and implementing an evidence-based strategy. World J Surg 38:1966–1977. https://doi.org/10.1007/s00268-014-2506-2
Asgeirsson T, El-Badawi KI, Mahmood A, Barletta J, Luchtefeld M, Senagore AJ (2010) Postoperative ileus: it costs more than you expect. J Am Coll Surg 210:228–231. https://doi.org/10.1016/j.jamcollsurg.2009.09.028
Ansari D, Gianotti L, Schröder J, Andersson R (2013) Fast-track surgery: procedure-specific aspects and future direction. Langenbeck’s Arch Surg 398:29–37. https://doi.org/10.1007/s00423-012-1006-9
Yang JH, Yoon JR, Oh CH, Kim TS (2012) Primary total knee arthroplasty using rotating-hinge prosthesis in severely affected knees. Knee Surg Sports Traumatol Arthrosc 20:517–523. https://doi.org/10.1007/s00167-011-1590-1
Thompson M, Magnuson B (2012) Management of postoperative ileus. Orthopedics 35:213–217. https://doi.org/10.3928/01477447-20120222-08
Vather R, Trivedi S, Bissett I (2013) Defining postoperative ileus: results of a systematic review and global survey. J Gastrointest Surg 17:962–972. https://doi.org/10.1007/s11605-013-2148-y
Venara A, Slim K, Regimbeau J-M, Ortega-Deballon P, Vielle B, Lermite E, Meurette G, Hamy A (2017) Proposal of a new classification of postoperative ileus based on its clinical impact-results of a global survey and preliminary evaluation in colorectal surgery. Int J Color Dis 32:797–803. https://doi.org/10.1007/s00384-017-2788-6
Ram CVS, Giles TD (2010) The evolving definition of systemic arterial hypertension. Curr Atheroscler Rep 12:155–158. https://doi.org/10.1007/s11883-010-0107-6
Harter K, Levine M, Henderson SO (2015) Anticoagulation drug therapy: a review. West J Emerg Med 16:11–17. https://doi.org/10.5811/westjem.2014.12.22933
Lu L, Liu M, Sun R, Zheng Y, Zhang P (2015) Myocardial infarction: symptoms and treatments. Cell Biochem Biophys 72:865–867. https://doi.org/10.1007/s12013-015-0553-4
Cassar A, Holmes DR, Rihal CS, Gersh BJ (2009) Chronic coronary artery disease: diagnosis and management. Mayo Clin Proc 84:1130–1146. https://doi.org/10.4065/mcp.2009.0391
(2010) Diagnosis and classification of diabetes mellitus. Diabetes Care 33:S62–S69 . doi: https://doi.org/10.2337/dc10-S062, 2009
Cockcroft DW, Gault MH (1976) Prediction of creatinine clearance from serum creatinine. Nephron 16:31–41. https://doi.org/10.1159/000180580
Thomas R, Kanso A, Sedor JR (2008) Chronic kidney disease and its complications. Prim Care 35:329–vii. https://doi.org/10.1016/j.pop.2008.01.008
Al Maaieh MA, Du JY, Aichmair A, Huang RC, Hughes AP, Cammisa FP, Girardi FP, Sama AA (2014) Multivariate analysis on risk factors for postoperative ileus after lateral lumbar interbody fusion. Spine 39:688–694. https://doi.org/10.1097/BRS.0000000000000238
Fineberg SJ, Nandyala SV, Kurd MF, Marquez-Lara A, Noureldin M, Sankaranarayanan S, Patel AA, Oglesby M, Singh K (2014) Incidence and risk factors for postoperative ileus following anterior, posterior, and circumferential lumbar fusion. Spine J 14:1680–1685. https://doi.org/10.1016/j.spinee.2013.10.015
Ritter MA, Harty LD (2004) Debate: simultaneous bilateral knee replacements: the outcomes justify its use. Clin Orthop Relat Res 428:84–86
Yu C, Tan S, Wang Z, Deng B, Li J, Wang Q, Zhou C, Kang X, Yu Z, Zhuang S (2018) Chronic kidney disease elicits an intestinal inflammation resulting in intestinal dysmotility associated with the activation of inducible nitric oxide synthesis in rat. Digestion 97:205–211. https://doi.org/10.1159/000481618
Vaziri ND, Wong J, Pahl M, Piceno YM, Yuan J, DeSantis TZ, Ni Z, Nguyen T-H, Andersen GL (2013) Chronic kidney disease alters intestinal microbial flora. Kidney Int 83:308–315. https://doi.org/10.1038/ki.2012.345
Strid H, Simrén M, Stotzer P-O, Ringström G, Abrahamsson H, Björnsson ES (2003) Patients with chronic renal failure have abnormal small intestinal motility and a high prevalence of small intestinal bacterial overgrowth. Digestion 67:129–137. https://doi.org/10.1159/000071292
Levine B, Kalman J, Mayer L, Fillit HM, Packer M (1990) Elevated circulating levels of tumor necrosis factor in severe chronic heart failure. N Engl J Med 323:236–241. https://doi.org/10.1056/NEJM199007263230405
Sandek A, Bauditz J, Swidsinski A, Buhner S, Weber-Eibel J, von Haehling S, Schroedl W, Karhausen T, Doehner W, Rauchhaus M, Poole-Wilson P, Volk H-D, Lochs H, Anker SD (2007) Altered intestinal function in patients with chronic heart failure. J Am Coll Cardiol 50:1561–1569. https://doi.org/10.1016/j.jacc.2007.07.016
Sandek A, Bjarnason I, Volk H-D, Crane R, Meddings JB, Niebauer J, Kalra PR, Buhner S, Herrmann R, Springer J, Doehner W, von Haehling S, Anker SD, Rauchhaus M (2012) Studies on bacterial endotoxin and intestinal absorption function in patients with chronic heart failure. Int J Cardiol 157:80–85. https://doi.org/10.1016/j.ijcard.2010.12.016
Pasini E, Aquilani R, Testa C, Baiardi P, Angioletti S, Boschi F, Verri M, Dioguardi F (2016) Pathogenic gut flora in patients with chronic heart failure. JACC: Heart Failure 4:220–227. https://doi.org/10.1016/j.jchf.2015.10.009
Wolthuis AM, Bislenghi G, Lambrecht M, Fieuws S, de Buck van Overstraeten A, Boeckxstaens G, D’Hoore A (2017) Preoperative risk factors for prolonged postoperative ileus after colorectal resection. Int J Colorectal Dis 32:883–890. https://doi.org/10.1007/s00384-017-2824-6
Menendez ME, Ring D, Bateman BT (2015) Preoperative opioid misuse is associated with increased morbidity and mortality after elective orthopaedic surgery. Clin Orthop Relat Res 473:2402–2412. https://doi.org/10.1007/s11999-015-4173-5
Shi Y, Zhang XP, Qin H, Yu YJ (2017) Naso-intestinal tube is more effective in treating postoperative ileus than naso-gastric tube in elderly colorectal cancer patients. Int J Color Dis 32:1047–1050. https://doi.org/10.1007/s00384-017-2760-5
Lambrichts DPV, Boersema GSA, Tas B, Wu Z, Vrijland WW, Kleinrensink G-J, Jeekel J, Lange JF, Menon AG (2017) Nicotine chewing gum for the prevention of postoperative ileus after colorectal surgery: a multicenter, double-blind, randomised, controlled pilot study. Int J Color Dis 32:1267–1275. https://doi.org/10.1007/s00384-017-2839-z
Acknowledgments
We would like to thank Thomas Leonhard, Albert Benzing, and Harald Lintl for their help with the study.
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AK conceived the study and did the data collection. AK, FA, and GM drafted the manuscript. AK and TN performed the statistical analysis. PD revised the manuscript. TH and TN supervised the study and did the final revision of the manuscript. All authors read and approved the final manuscript.
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Klasan, A., Amic, F., Dworschak, P. et al. Risk factors for ileus after hip and knee arthroplasty. Int J Colorectal Dis 34, 261–267 (2019). https://doi.org/10.1007/s00384-018-3184-6
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DOI: https://doi.org/10.1007/s00384-018-3184-6