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Role of family history and tumor location on prognosis of patients with colorectal cancer and synchronous metastases

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International Journal of Colorectal Disease Aims and scope Submit manuscript

An Erratum to this article was published on 02 August 2017

This article has been updated

Abstract

Background/aims

Family history of colorectal cancer and tumor location along colon-rectum have been reported as prognostic factors. The aim of the current study is to analyze the role of both on overall survival in a series of patients with metastatic colorectal cancer with synchronous metastases.

Methods

A retrospective mono-institutional analysis has been performed on patients, who received chemotherapy from 2004 to 2008. A Cox proportional-hazards regression was used to calculate hazard ratio (HR) for death, after adjustment for other variables (tumor metastasectomy, number of organs involved with metastases, number of anti-neoplastic drugs, age, sex, tumor grade, baseline CEA).

Results

Two hundred and seven patients were included in the study. Only tumor metastasectomy was related with a better overall survival (HR 4.995; P < 0.001), whereas a positive family history was associated with a poor prognosis (HR 0.386; P = 0.021). After exclusion of rectal tumors, the negative prognostic effect of a positive family history appeared limited to patients with a left-sided colon cancer (HR 0.183; P = 0.036).

Conclusion

Family history for colorectal cancer in a first-degree relative, and not tumor location, has a significant relationship with the prognosis of patients with a colorectal cancer and synchronous metastases.

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Fig. 1

Change history

  • 02 August 2017

    An erratum to this article has been published.

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Authors and Affiliations

  1. Department of Oncology, G. Borea Hospital, Via G. Borea n. 56, 18038, Sanremo, Imperia, Italy

    Colloca Giuseppe & Venturino Antonella

Authors
  1. Colloca Giuseppe
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  2. Venturino Antonella
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Corresponding author

Correspondence to Colloca Giuseppe.

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Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

An erratum to this article is available at https://doi.org/10.1007/s00384-017-2877-6.

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Giuseppe, C., Antonella, V. Role of family history and tumor location on prognosis of patients with colorectal cancer and synchronous metastases. Int J Colorectal Dis 32, 1069–1072 (2017). https://doi.org/10.1007/s00384-017-2831-7

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  • DOI: https://doi.org/10.1007/s00384-017-2831-7

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