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Risk factors for surgical site infection following colorectal resection: a multi-institutional study

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International Journal of Colorectal Disease Aims and scope Submit manuscript



Surgical site infection (SSI) is an infection occurring in an incisional wound within 30 days of surgery and significantly affects patients undergoing colorectal surgery. This study examined a multi-institutional dataset to determine risk factors for SSI following colorectal resection.


Data on 386 patients who underwent colorectal resection in three institutions were accrued. Patients were identified using a prospective SSI database and hospital records. Data are presented as median (interquartile range), and logistic regression analysis was used to identify risk factors.


Patients (21.5 %) developed a postoperative SSI. The median time to the development of SSI was 7 days (5–10). Of all infections, 67.5 % were superficial, 22.9 % were deep and 9.6 % were organ space. In univariate analysis, an ASA grade of II (RR 0.6, CI 0.3–0.9, P = 0.019), having an elective procedure (RR 0.4, CI 0.2–0.6, P < 0.001), using a laparoscopic approach (RR 0.5, CI 0.3–0.9, P = 0.019), having a daytime procedure (RR 0.3, CI 0.1–0.7, P = 0.006) and having a clean/contaminated wound (RR 0.4, CI 0.2–0.7, P = 0.001) were associated with reduced risk of SSI. In multivariate analysis, an ASA grade of IV (RR 3.9, CI 1.1–13.7, P = 0.034), a procedure duration over 3 h (RR 4.3, CI 2.3–8.2, P < 0.001) and undergoing a panproctocolectomy (RR 6.5, CI 1.0–40.9, P = 0.044) were independent risk factors for SSI. Those who developed an SSI had a longer duration of inpatient stay (22 days [16–31] vs 15 days [10–26], P < 0.001).


Patients who develop an SSI have a longer duration of inpatient stay. Independent risk factors for SSI following colorectal resection include being ASA grade IV, having a procedure duration over 3 h, and undergoing a panproctocolectomy.

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Correspondence to Derek B. Hennessey.

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Hennessey, D.B., Burke, J.P., Ni-Dhonochu, T. et al. Risk factors for surgical site infection following colorectal resection: a multi-institutional study. Int J Colorectal Dis 31, 267–271 (2016).

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