Abstract
Purpose
The aim of this study is to better understand the main aspects related to colorectal carcinoma diagnosed in the first 10 years of life, through a systematic review.
Methods
We carried out a bibliographic search in PubMed and LILACS, focusing on identifying publications or case reports about colorectal carcinoma in the first 10 years of life. The bibliographical analysis was made in two steps. During the first phase, we excluded those articles whose titles or abstracts did not correspond with the objective settled. Publications without abstract were also included in this phase. During the second phase, we look at the articles and evaluated their content, selecting the cases with colorectal cancer under 10 years old.
Results
From 3880 publications, 132 were selected in the first phase and 84 were evaluated in the second phase. Based on these conditions, 33 articles have cases presented which 4 articles were case reviews and 29 were case reports. Duplicated cases were excluded from the analysis. Fifty-nine cases were described in English and Latin literature. There is an apparent similar proportion between the sexes, and the mean age was 8.6 years old. The main localization was the rectum and sigmoid (45.8 %). Pathologic findings showed that 86.4 % were adenocarcinoma. These tumors are frequently advanced at diagnosis. The Kaplan-Meier 60-month overall survival was 15.3 %. Dukes classification represents a factor related to survival (p = 0.03).
Conclusions
In children, colorectal carcinoma presents distinctive characteristics, which determines poor survival.
Similar content being viewed by others
References
Siegel R, Desantis C, Jemal A (2014) Colorectal cancer statistics, 2014. CA: Cancer J Clin 64(2):104–117. doi:10.3322/caac.21220
Ivanovich JL, Read TE, Ciske DJ, Kodner IJ, Whelan AJ (1999) A practical approach to familial and hereditary colorectal cancer. Am J Med 107(1):68–77
Andersson A, Bergdahl L (1976) Carcinoma of the colon in children: a report of six new cases and a review of the literature. J Pediatr Surg 11(6):967–971
Brown RA, Rode H, Millar AJ, Sinclair-Smith C, Cywes S (1992) Colorectal carcinoma in children. J Pediatr Surg 27(7):919–921
Caffarena PE, Dodero P, Magillo P, Soave F (1981) Adenocarcinoma of the rectosigmoid colon in a 10-yr-old child. J Pediatr Surg 16(1):87–89
Chattopadhyay S, Gupta P, Aich RK, Deb AR (2012) Colorectal carcinoma in a ten-year-old girl: a case report. J Cancer Res Ther 8(1):120–122. doi:10.4103/0973-1482.95189
Donaldson MH, Taylor P, Rawitscher R, Sewell JB Jr (1971) Colon carcinoma in childhood. Pediatrics 48(2):307–312
Driver CP, Bowen J, Bruce J (1998) Adenocarcinoma of the appendix in a child. J Pediatr Surg 33(9):1437–1438
Durno C, Aronson M, Bapat B, Cohen Z, Gallinger S (2005) Family history and molecular features of children, adolescents, and young adults with colorectal carcinoma. Gut 54(8):1146–1150. doi:10.1136/gut.2005.066092
Ferrari A, Rognone A, Casanova M, Zaffignani E, Piva L, Collini P, Bertario L, Sala P, Leo E, Belli F, Gallino G (2008) Colorectal carcinoma in children and adolescents: the experience of the Istituto Nazionale Tumori of Milan, Italy. Pediatr Blood Cancer 50(3):588–593. doi:10.1002/pbc.21220
Hamazaki M, Kono S, Mimaya J, Ishihara A (1987) Signet ring cell carcinoma in a polyp of the colon. A case report of a six-year-old boy. Acta Pathol Jpn 37(10):1679–1684
Karnak I, Ciftci AO, Senocak ME, Buyukpamukcu N (1999) Colorectal carcinoma in children. J Pediatr Surg 34(10):1499–1504
Kern WH, White WC (1958) Adenocarcinoma of the colon in a 9-month-old infant; report of a case. Cancer 11(4):855–857
Lamego CM, Torloni H (1989) Colorectal adenocarcinoma in childhood and adolescent. Report of 11 cases and review of the literature. Pediatr Radiol 19(8):504–508
Li-Chang HH, Driman DK, Levin H, Siu VM, Scanlan NL, Buckley K, Cairney AE, Ainsworth PJ (2013) Colorectal cancer in a 9-year-old due to combined EPCAM and MSH2 germline mutations: case report of a unique genotype and immunophenotype. J Clin Pathol 66(7):631–633. doi:10.1136/jclinpath-2012-201376
Lopes A, Vieira RAC, Soares FA, Penna SD (2001) Adenocarcinoma colorretal na primeira década. Rev Col Bras Cir 28(S1):232
Musa AA, Agboola AO, Banjo AA, Shonubi AM (2007) Rectal carcinoma in a nine-year-old Nigerian male child: case report. East Afr Med J 84(2):93–96
Odone V, Chang L, Caces J, George SL, Pratt CB (1982) The natural history of colorectal carcinoma in adolescents. Cancer 49(8):1716–1720
Pandey A, Gangopadhyay A, Sharma S, Kumar V, Gupta D, Gopal S, Singh R (2008) Pediatric carcinoma of rectum—Varanasi experience. Indian J Cancer 45(3):119–122
Pemberton M (1970) Carcinoma of the large intestine with survival in a child of nine and in his father. A study of carcinoma of the colon with particular reference to children. Br J Surg 57(11):841–846
Perkel LL, Alaghemand A (1962) Carcinoma of the colon in children. Am J Proctol 13:170–173
Philibert M, Dodat H, Bouvier R, Chappuis JP, Daudet M (1984) Recto-sigmoid cancer and polyps in children. Comments apropos of 2 cases of atypical juvenile polyps. Chir Pediatr 25(1):28–31
Pratt CB, Rivera G, Shanks E, Johnson WW, Howarth C, Terrell W, Kumar AP (1977) Colorectal carcinoma in adolescents implications regarding etiology. Cancer 40(5 Suppl):2464–2472
Radhakrishnan CN, Bruce J (2003) Colorectal cancers in children without any predisposing factors. A report of eight cases and review of the literature. Eur J Pediatr Surg 13(1):66–68. doi:10.1055/s-2003-38300
Rastogi V, Singhal PK, Chadha R, Taneja SB (1988) Adenocarcinoma of the colon in a child. Indian J Gastroenterol 7(3):182
Reynoso-Garcia M, Hernandez M, Carvallo-Lazaro B (1985) Adenocarcinoma of the colon in childhood. Bol Med Hosp Infant Mex 42(1):62–65
Sasi OA, Sathiapalan R, Rifai A, Tulbah AM, Al-Mehaidib A, Kofide A, Hugosson C (2005) Colonic neuroendocrine carcinoma in a child. Pediatr Radiol 35(3):339–343. doi:10.1007/s00247-004-1319-0
Schilla FW (1954) Carcinoma in a rectal polyp; report of a case in infancy. Am J Surg 88(5):759–760
Shah RS, Pikale HS, Birmole BJ, Kulkarni BK, Borwankar SS (1992) Adenocarcinoma of the colon in a child. J Postgrad Med 38(2):81–83
Siufi AA, Possik RA, Giannotti Filho O, Abrao A (1977) Adenocarcinoma of the transverse colon in children. Rev Paul Med 90(3–4):78–79
Suster G, Weinberg AG, Graivier L (1977) Carcinoid tumor of the colon in a child. J Pediatr Surg 12(5):739–742
Vastyan AM, Walker J, Pinter AB, Gerrard M, Kajtar P (2001) Colorectal carcinoma in children and adolescents—a report of seven cases. Eur J Pediatr Surg 11(5):338–341. doi:10.1055/s-2001-18548
Middelkamp JN, Haffner H (1963) Carcinoma of the colon in children. Pediatrics 32:558–571
Yamamoto K, Tanaka T, Kuno K, Amoh Y, Takahashi Y, Murakami H (1994) Carcinoma of the colon in children: case report and review of the Japanese literature. J Gastroenterol 29(5):647–652
Taguchi T, Suita S, Hirata Y, Ishii E, Ueda K (1991) Carcinoma of the colon in children: a case report and review of 41 Japanese cases. J Pediatr Gastroenterol Nutr 12(3):394–399
Takai S, Yamamura M, Sakaguchi M, Uetsuji S, Yamamoto M (1988) Carcinoma of the colon in children: report of a case and review of the literature. Jpn J Surg 18(3):341–345
Toki A, Todani T, Watanabe Y, Ogura K, Miyauchi A, Agatsuma Y (1997) Carcinoma of the colon in childhood; report of 2 cases expressing p53 without K-ras mutation. Eur J Pediatr Surg 7(5):315–317. doi:10.1055/s-2008-1071183
de la Chapelle A (1999) Testing tumors for microsatellite instability. Eur J Hum Genet 7(4):407–408. doi:10.1038/sj.ejhg.5200335
Bethel CA, Bhattacharyya N, Hutchinson C, Ruymann F, Cooney DR (1997) Alimentary tract malignancies in children. J Pediatr Surg 32(7):1004–1008, discussion 1008–1009
Chabalko JJ, Fraumeni JF Jr (1975) Colorectal cancer in children: epidemiologic aspects. Dis Colon Rectum 18(1):1–3
Ministério da Sáude (1991) Registro Nacional de Patologia Tumoral. Diagnóstico de Câncer. Brasil 1981/86., vol 1
Soliman AS, Bondy ML, Levin B, Hamza MR, Ismail K, Ismail S, Hammam HM, el-Hattab OH, Kamal SM, Soliman AG, Dorgham LA, McPherson RS, Beasley RP (1997) Colorectal cancer in Egyptian patients under 40 years of age. Int J Cancer 71(1):26–30
Pratt CB, George SL, Green AA, Fields LA, Dodge RK (1988) Carcinomas in children. Clinical and demographic characteristics. Cancer 61(5):1046–1050
Densmore TL, Langer JC, Molleston JP, Dehner LP, Coffin CM (1996) Colorectal adenocarcinoma as a second malignant neoplasm following Wilms’ tumor and rhabdomyosarcoma. Med Pediatr Oncol 27(6):556–560. doi:10.1002/(SICI)1096-911X(199612)27:6<556::AID-MPO9>3.0.CO;2-K
Jarvinen HJ, Turunen MJ (1984) Colorectal carcinoma before 40 years of age: prognosis and predisposing conditions. Scand J Gastroenterol 19(5):634–638
Syngal S, Fox EA, Li C, Dovidio M, Eng C, Kolodner RD, Garber JE (1999) Interpretation of genetic test results for hereditary nonpolyposis colorectal cancer: implications for clinical predisposition testing. JAMA 282(3):247–253
Hall NR, Bishop DT, Stephenson BM, Finan PJ (1996) Hereditary susceptibility to colorectal cancer. Relatives of early onset cases are particularly at risk. Dis Colon Rectum 39(7):739–743
Kashiwagi H, Senba S, Konishi F, Konishi M, Miyaki M, Shoji M, Kanazawa K (1999) Rectal cancer in a 13-year-old boy without a detectable germline mutation in FAP and HNPCC genes. J Gastroenterol 34(3):341–344
Shankar A, Renaut AJ, Whelan J, Taylor I (1999) Colorectal cancer in adolescents. Ann R Coll Surg Engl 81(2):100–104
Gryfe R, Swallow C, Bapat B, Redston M, Gallinger S, Couture J (1997) Molecular biology of colorectal cancer. Curr Probl Cancer 21(5):233–300
Fearon ER, Vogelstein B (1990) A genetic model for colorectal tumorigenesis. Cell 61(5):759–767
Fitzgibbons RJ Jr, Lynch HT, Stanislav GV, Watson PA, Lanspa SJ, Marcus JN, Smyrk T, Kriegler MD, Lynch JF (1987) Recognition and treatment of patients with hereditary nonpolyposis colon cancer (Lynch syndromes I and II). Ann Surg 206(3):289–295
Cain AS, Longino LA (1970) Carcinoma of the colon in children. J Pediatr Surg 5(5):527–532
Kaplan EL, Meier P (1958) Non-parametric stimulation from incomplete observations. J Am Stat Assoc 53:457–481
Khan AM, Doig CM, Dickson AP (1997) Advanced colonic carcinoma in children. Postgrad Med J 73(857):169–170
LaQuaglia MP, Heller G, Filippa DA, Karasakalides A, Vlamis V, Wollner N, Enker WE, Cohen AM, Exelby PR (1992) Prognostic factors and outcome in patients 21 years and under with colorectal carcinoma. J Pediatr Surg 27(8):1085–1089, discussion 1089–1090
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
da Costa Vieira, R.A., Tramonte, M.S. & Lopes, L.F. Colorectal carcinoma in the first decade of life: a systematic review. Int J Colorectal Dis 30, 1001–1006 (2015). https://doi.org/10.1007/s00384-015-2202-1
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00384-015-2202-1