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Lethal 5-fluorouracil toxicity in a colorectal patient with severe dihydropyrimidine dehydrogenase (DPD) deficiency

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References

  1. Morel A, Boisdron-Celle M, Fey L et al (2006) Clinical relevance of different dihydropyrimidine dehydrogenase gene single nucleotide polymorphisms on 5-fluorouracil tolerance. Mol Cancer Ther 5:2895–04

    Article  CAS  PubMed  Google Scholar 

  2. Amstutz U, Froehlich TK, Largiadèr CR (2011) Dihydropyrimidine dehydrogenase gene as a major predictor of severe 5-fluorouracil toxicity. Pharmacogenomics 12:1321–1336

    Article  CAS  PubMed  Google Scholar 

  3. Van Kuilenburg ABP (2004) Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluorouracil. Eur J Cancer 40:939–950

    Article  PubMed  Google Scholar 

  4. Caudle KE, Thorn CF, Klein TE et al (2013) Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing. Clin Pharmacol Ther 94:640–645

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgments

We are grateful to Christine Pivot (Services Pharmaceutiques, Groupement Hospitalier Edouard Herriot, Hospices Civils de Lyon, Lyon, France) for her support and advice.

Conflict of interest

Authors reported none.

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Authors and Affiliations

  1. Department of Pharmacy, Centre Hospitalier Universitaire de Grenoble, Grenoble, France

    Carole Dhelens, Claire Chapuis & Pierrick Bedouch

  2. Department of Medical Intensive Care Unit, Centre Hospitalier Universitaire de Grenoble, Grenoble, France

    Agnès Bonadona, Leila Potton & Carole Schwebel

  3. Department of Pharmacology, IUCT-O, Institut Claudius Regaud, Toulouse, France

    Fabienne Thomas & Sabrina Marsili

  4. University Toulouse III Paul Sabatier/EA4553, Toulouse, France

    Fabienne Thomas & Sabrina Marsili

  5. Grenoble-Alpes University UJF-Grenoble 1/CNRS/TIMC-IMAG, UMR 5525/Themas, Grenoble, France

    Pierrick Bedouch

  6. Grenoble-Alpes University UJF Grenoble 1/Inserm U1039, Grenoble, France

    Carole Schwebel

  7. CHU Grenoble, Pôle Pharmacie, Pharmacie clinique, Pavillon Vercors, CS 10217, 38043, Grenoble cedex 9, France

    Carole Dhelens

Authors
  1. Carole Dhelens
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  2. Agnès Bonadona
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  3. Fabienne Thomas
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  4. Claire Chapuis
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  5. Leila Potton
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  6. Sabrina Marsili
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  7. Pierrick Bedouch
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  8. Carole Schwebel
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Corresponding author

Correspondence to Carole Dhelens.

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Dhelens, C., Bonadona, A., Thomas, F. et al. Lethal 5-fluorouracil toxicity in a colorectal patient with severe dihydropyrimidine dehydrogenase (DPD) deficiency. Int J Colorectal Dis 31, 699–701 (2016). https://doi.org/10.1007/s00384-015-2191-0

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  • DOI: https://doi.org/10.1007/s00384-015-2191-0

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