The incidence of mucinous appendiceal malignancies: a population-based study



Mucinous appendiceal tumours were described already 180 years ago, but reliable data on the incidence of these tumours are sparse. The clinical importance of these tumours is increasing since they are now identified as the most common site of origin for pseudomyxoma peritonei (PMP), which is currently recognised as a treatable condition.


Data on the incidence of mucinous appendiceal tumours were retrieved from the Eindhoven Cancer Registry, which collects data on all patients with newly diagnosed cancer in a large part of the southern Netherlands that comprises about 2.3 million inhabitants. From 1980 to 2010, all cases of primary adenocarcinomas of the appendix were included.


From 1980 to 2010, a mucinous adenocarcinoma was diagnosed in 78 patients being 48 % of all cases of appendiceal adenocarcinoma diagnosed during this period (n = 164). The incidence increased during the study period from 0.6 to 1.9 per 1,000,000 person-years for women and from 0.4 to 1.0 per 1,000,000 person-years for men.


The reported incidence of mucinous adenocarcinomas of the appendix shows an increasing trend. This is probably mainly explained by the increased awareness of this tumour and its relation with PMP, and better registration of this specific diagnosis.

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  1. 1.

    Smeenk RM, van Velthuysen ML, Verwaal VJ, Zoetmulder FA (2008) Appendiceal neoplasms and pseudomyxoma peritonei: a population based study. Eur J Surg Oncol 34:196–201

    PubMed  Article  CAS  Google Scholar 

  2. 2.

    Smeenk RM, Bruin SC, van Velthuysen ML, Verwaal VJ (2008) Pseudomyxoma peritonei. Curr Probl Surg 45:527–75

    PubMed  Article  Google Scholar 

  3. 3.

    Trivedi AN, Levine EA, Mishra G (2009) Adenocarcinoma of the appendix is rarely detected by colonoscopy. J Gastrointest Surg 13:668–75

    PubMed  Article  Google Scholar 

  4. 4.

    Chua TC, Moran BJ, Sugarbaker PH et al (2012) Early- and Long-Term Outcome Data of Patients With Pseudomyxoma Peritonei From Appendiceal Origin Treated by a Strategy of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy. J Clin Oncol

  5. 5.

    McCusker ME, Cote TR, Clegg LX, Sobin LH (2002) Primary malignant neoplasms of the appendix: a population-based study from the surveillance, epidemiology and end-results program, 1973–1998. Cancer 94:3307–12

    PubMed  Article  Google Scholar 

  6. 6.

    Turaga KK, Pappas SG, Gamblin T (2012) Importance of histologic subtype in the staging of appendiceal tumors. Ann Surg Oncol 19:1379–85

    PubMed  Article  Google Scholar 

  7. 7.

    Benedix F, Reimer A, Gastinger I et al (2010) Primary appendiceal carcinoma–epidemiology, surgery and survival: results of a German multi-center study. Eur J Surg Oncol 36:763–71

    PubMed  Article  CAS  Google Scholar 

  8. 8.

    Bucher P, Mathe Z, Demirag A, Morel P (2004) Appendix tumors in the era of laparoscopic appendectomy. Surg Endosc 18:1063–6

    PubMed  Article  CAS  Google Scholar 

  9. 9.

    Nitecki SS, Wolff BG, Schlinkert R, Sarr MG (1994) The natural history of surgically treated primary adenocarcinoma of the appendix. Ann Surg 219:51–7

    PubMed  Article  CAS  Google Scholar 

  10. 10.

    Evers DJ, Verwaal VJ (2011) Indication for oophorectomy during cytoreduction for intraperitoneal metastatic spread of colorectal or appendiceal origin. Br J Surg 98:287–92

    PubMed  Article  CAS  Google Scholar 

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Correspondence to I. H. J. T. de Hingh.

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van den Heuvel, M.G.W., Lemmens, V.E.P.P., Verhoeven, R.H.A. et al. The incidence of mucinous appendiceal malignancies: a population-based study. Int J Colorectal Dis 28, 1307–1310 (2013).

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  • Mucinous
  • Adenocarcinoma
  • Appendix
  • Pseudomyxoma peritonei
  • Appendiceal tumour