International Journal of Colorectal Disease

, Volume 28, Issue 9, pp 1307–1310 | Cite as

The incidence of mucinous appendiceal malignancies: a population-based study

  • M. G. W. van den Heuvel
  • V. E. P. P. Lemmens
  • R. H. A. Verhoeven
  • I. H. J. T. de HinghEmail author
Original Article



Mucinous appendiceal tumours were described already 180 years ago, but reliable data on the incidence of these tumours are sparse. The clinical importance of these tumours is increasing since they are now identified as the most common site of origin for pseudomyxoma peritonei (PMP), which is currently recognised as a treatable condition.


Data on the incidence of mucinous appendiceal tumours were retrieved from the Eindhoven Cancer Registry, which collects data on all patients with newly diagnosed cancer in a large part of the southern Netherlands that comprises about 2.3 million inhabitants. From 1980 to 2010, all cases of primary adenocarcinomas of the appendix were included.


From 1980 to 2010, a mucinous adenocarcinoma was diagnosed in 78 patients being 48 % of all cases of appendiceal adenocarcinoma diagnosed during this period (n = 164). The incidence increased during the study period from 0.6 to 1.9 per 1,000,000 person-years for women and from 0.4 to 1.0 per 1,000,000 person-years for men.


The reported incidence of mucinous adenocarcinomas of the appendix shows an increasing trend. This is probably mainly explained by the increased awareness of this tumour and its relation with PMP, and better registration of this specific diagnosis.


Mucinous Adenocarcinoma Appendix Pseudomyxoma peritonei Appendiceal tumour 


  1. 1.
    Smeenk RM, van Velthuysen ML, Verwaal VJ, Zoetmulder FA (2008) Appendiceal neoplasms and pseudomyxoma peritonei: a population based study. Eur J Surg Oncol 34:196–201PubMedCrossRefGoogle Scholar
  2. 2.
    Smeenk RM, Bruin SC, van Velthuysen ML, Verwaal VJ (2008) Pseudomyxoma peritonei. Curr Probl Surg 45:527–75PubMedCrossRefGoogle Scholar
  3. 3.
    Trivedi AN, Levine EA, Mishra G (2009) Adenocarcinoma of the appendix is rarely detected by colonoscopy. J Gastrointest Surg 13:668–75PubMedCrossRefGoogle Scholar
  4. 4.
    Chua TC, Moran BJ, Sugarbaker PH et al (2012) Early- and Long-Term Outcome Data of Patients With Pseudomyxoma Peritonei From Appendiceal Origin Treated by a Strategy of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy. J Clin OncolGoogle Scholar
  5. 5.
    McCusker ME, Cote TR, Clegg LX, Sobin LH (2002) Primary malignant neoplasms of the appendix: a population-based study from the surveillance, epidemiology and end-results program, 1973–1998. Cancer 94:3307–12PubMedCrossRefGoogle Scholar
  6. 6.
    Turaga KK, Pappas SG, Gamblin T (2012) Importance of histologic subtype in the staging of appendiceal tumors. Ann Surg Oncol 19:1379–85PubMedCrossRefGoogle Scholar
  7. 7.
    Benedix F, Reimer A, Gastinger I et al (2010) Primary appendiceal carcinoma–epidemiology, surgery and survival: results of a German multi-center study. Eur J Surg Oncol 36:763–71PubMedCrossRefGoogle Scholar
  8. 8.
    Bucher P, Mathe Z, Demirag A, Morel P (2004) Appendix tumors in the era of laparoscopic appendectomy. Surg Endosc 18:1063–6PubMedCrossRefGoogle Scholar
  9. 9.
    Nitecki SS, Wolff BG, Schlinkert R, Sarr MG (1994) The natural history of surgically treated primary adenocarcinoma of the appendix. Ann Surg 219:51–7PubMedCrossRefGoogle Scholar
  10. 10.
    Evers DJ, Verwaal VJ (2011) Indication for oophorectomy during cytoreduction for intraperitoneal metastatic spread of colorectal or appendiceal origin. Br J Surg 98:287–92PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • M. G. W. van den Heuvel
    • 1
  • V. E. P. P. Lemmens
    • 2
    • 3
  • R. H. A. Verhoeven
    • 2
  • I. H. J. T. de Hingh
    • 1
    Email author
  1. 1.Department of Surgical OncologyCatharina Hospital EindhovenEindhovenThe Netherlands
  2. 2.Eindhoven Cancer Registry/Comprehensive Cancer Centre SouthEindhovenThe Netherlands
  3. 3.Department of Public HealthErasmus MC University Medical CenterRotterdamThe Netherlands

Personalised recommendations