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PLA2G4A mutants modified protective effect of tea consumption against colorectal cancer

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Purpose

The primary aim was to respectively evaluate PLA2G4A mutants modifying protective effect of tea consumption against colorectal cancer (CRC), colon and rectal cancer.

Methods

All participants were recruited from January 2006 to April 2008. The information about tea consumption was collected by a structured questionnaire. CRC patients were diagnosed based on histology. Four single-nuclear polymorphisms (SNPs) in PLA2G4A gene were selected. Multiple logistic regression models were used for assessing the joint effects between tea consumption and SNPs on CRC, colon and rectal cancer.

Results

Three hundred patients with CRC and 296 controls well-matched were used in the final analyses. The significant individual associations between four SNPs (rs6666834, rs10911933, rs4650708 and rs7526089) and CRC were not observed. However, their CTAC haplotype was significantly associated with the increased risk of CRC (OR = 3.06; 95%CI = 1.52–6.19), compared with TCAC haplotype. Drinking tea was correlated with a decreased risk of CRC after adjustment for covariates (OR = 0.61; 95%CI = 0.39–0.97). Meanwhile, compared with no-tea drinkers with TT/CT genotype of rs6666834, tea drinkers with TT/CT or CC had significant lower risk of CRC (OR = 0.6, 95%CI = 0.36–1.00 for TT/CT; 0.38, 0.19–0.74 for CC). The joint effects between the remaining three SNPs and drinking tea on CRC were observed as well. Similar findings were observed on colon and rectal cancers.

Conclusions

Tea consumption and haplotype of mutants in PLA2G4A gene were respectively associated with the risk of CRC. PLA2G4A mutants modified the protective effect of tea consumption against CRC, colon and rectal cancers in Chinese population.

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Acknowledgment

The study was funded, in part, by grants from the Natural Science Foundation of Zhejiang Province (Y2090154), New Teacher Foundation of Ministry of Education (20090101120103), Department of Education of Zhejiang Province (Z200804565) and Zhejiang Foundation of Young Teachers’ innovation (2009QNA7018).

We thank the staff of the Cancer Institute of Jiashan County for their continuous support and assistance to collect the epidemiological data and blood specimen. We would like to particularly thank all participants and their family for their contributions and supports.

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Authors and Affiliations

  1. Department of Epidemiology & Health Statistics, School of Public Health, Zhejiang University, 866 Yu-Hang-Tang Road, Xihu District, Hangzhou, Zhejiang, 310058, China

    Yunxian Yu, Mingwu Zhang, Yifeng Pan, Mingjuan Jin, Xia Jiang, Shanchun Zhang, Yinyin Wu, Qun Ni & Kun Chen

  2. Institute of Cancer Research and Prevention of Jiashan County, Jiashan, 314100, Zhejiang, China

    Qilong Li

Authors
  1. Yunxian Yu
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  2. Mingwu Zhang
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  5. Xia Jiang
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Corresponding author

Correspondence to Kun Chen.

Appendix

Appendix

Table 6 The individual and joint adjusted association of drinking tea and cPLA2G4A gene polymorphisms with colon cancer, respectively
Full size table
Table 7 The individual adjusted association of drinking tea and cPLA2G4A gene polymorphisms with rectal cancer, respectively
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Table 8 The adjusted joint effect of drinking tea and cPLA2G4A gene polymorphisms on the risk of colon cancer
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Table 9 The adjusted joint effect of drinking tea and cPLA2G4A gene polymorphisms on the risk of rectal cancer
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Table 10 The adjusted between haplotype of cPLA2G4A gene polymorphisms and colon cancer
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Table 11 The adjusted association between haplotype of cPLA2G4A gene polymorphisms and rectal cancer
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Yu, Y., Zhang, M., Pan, Y. et al. PLA2G4A mutants modified protective effect of tea consumption against colorectal cancer. Int J Colorectal Dis 27, 1005–1013 (2012). https://doi.org/10.1007/s00384-012-1417-7

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  • DOI: https://doi.org/10.1007/s00384-012-1417-7

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