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Association of OGG1 Ser326Cys polymorphism with colorectal cancer risk: a meta-analysis

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Introduction

8-Oxoguanine DNA glycosylase 1 (OGG1), a key protein involved in the base excision repair pathway, can recognize and excise several lesions from oligodeoxynucleotides with single DNA damage. A C/G polymorphism at 1,245 bp (C1245G) in exon 7 of the OGG1 (Ser326Cys, rs1052133) is found to have a lower enzymatic activity. A variety of case–control studies have been published evaluating the association between OGG1 Ser326Cys polymorphism and colorectal cancer (CRC), though their conclusions were always contradictory.

Materials and methods

This meta-analysis enrolled 12 studies to estimate the overall risk of OGG1 Ser326Cys polymorphism associated with CRC. The pooled odds ratios (ORs) were performed for codominant model (Cys/Cys versus Ser/Ser; Ser/Cys versus Ser/Ser), dominant model (Ser/Cys + Cys/Cys versus Ser/Ser) and recessive model (Cys/Cys versus Ser/Cys + Ser/Ser).

Results

No significant associations were found for Cys/Cys versus Ser/Ser (OR = 1.19, 95% confidence interval (CI) 0.92–1.53), Ser/Cys versus Ser/Ser (OR = 1.04, 95% CI 0.95–1.13), Ser/Cys + Cys/Cys versus Ser/Ser (OR = 1.06, 95% CI 0.98–1.16) and Cys/Cys versus Ser/Cys + Ser/Ser (OR = 1.11, 95% CI 0.90–1.38); moreover, in the stratified analyses, no significantly increased risk was found for all genetic models.

Conclusions

Our meta-analysis suggests that the OGG1 Ser326Cys polymorphism is not associated with CRC risk.

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Acknowledgments

This project was supported by a grant from the Social Development Technology Projects of Kunshan City, China (KS1013) and a grant from The Technology Development Program of Nanjing Medical University, Jiangsu Province, China (08NMUM107).

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Authors and Affiliations

  1. Clinical Laboratory, Traditional Chinese Medicine Hospital of Kunshan, Kunshan, 215300, Jiangsu Province, China

    Ying Zhang

  2. The Central Laboratory of Nanjing, First Hospital Affiliated to Nanjing Medical University, Nanjing, 210006, Jiangsu Province, China

    Bang-Shun He, Yu-Qin Pan, Ye-Qiong Xu & Shu-Kui Wang

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  1. Ying Zhang
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  2. Bang-Shun He
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  3. Yu-Qin Pan
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Corresponding author

Correspondence to Shu-Kui Wang.

Additional information

Ying Zhang and Bang-Shun He contributed equally to this work and should be considered as co-first authors.

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Zhang, Y., He, BS., Pan, YQ. et al. Association of OGG1 Ser326Cys polymorphism with colorectal cancer risk: a meta-analysis. Int J Colorectal Dis 26, 1525–1530 (2011). https://doi.org/10.1007/s00384-011-1258-9

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