Skip to main content

Association between adiponectin, resistin, insulin resistance, and colorectal tumors

International Journal of Colorectal Disease volume 25, pages 205–212 (2010)Cite this article

Abstract

Purpose

In this study, we have examined the correlation between colorectal cancer (CRC) and serum adiponectin and resistin levels, body mass index and insulin resistance.

Methods

The relation between serum adiponectin and resistin levels, obesity and insulin resistance in 36 CRC patients and 37 controls was examined.

Results

Insulin and homeostasis model assessment insulin resistance index (HOMA-IR) levels were higher, and adiponectin levels were significantly decreased in patients versus controls, whereas, resistin levels were significantly increased. A negative correlation between adiponectin, HOMA-IR, and insulin and a positive correlation between HOMA-IR, insulin, and stage were detected. There was no correlation between the stage and resistin. Adiponectin level negatively correlated with the stage. Adiponectin and resistin could play a role in colon cancer carcinogenesis, and adiponectin could be responsible for poor prognosis in colorectal cancer.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

43,34 €

Price includes VAT (Finland)
Tax calculation will be finalised during checkout.

Fig. 1
Fig. 2

References

  1. Parkin DM, Pisani P, Ferlay J (1999) Global cancer statistics. CA Cancer J Clin 49:33–64

    Article  CAS  PubMed  Google Scholar 

  2. Singh PN, Fraser GE (1998) Dietary risk factors for colon cancer in a low-risk population. Am J Epidemiol 148:761–774

    CAS  PubMed  Google Scholar 

  3. Slattery ML, Potter J, Caan B, Edwards S, Coates A, Ma KN, Berry TD (1997) Energy balance and colon cancer—beyond physical activity. Cancer Res 57:75–80

    CAS  PubMed  Google Scholar 

  4. Soliman PT, Wu D, Tortolero-Luna G, Schmeler KM, Slomovitz BM, Bray MS, Gershenson DM, Lu KH (2006) Association between adiponectin, insulin resistance, and endometrial cancer. Cancer 106:2376–2381

    Article  CAS  PubMed  Google Scholar 

  5. Chasan-Taber S, Rimm EB, Stampfer MJ, Spiegelman D, Colditz GA, Giovannucci E, Ascherio A, Willett WC (1996) Reproducibility and validity of a self-administered physical activity questionnaire for male health profesionals. Epidemiology 7:81–86

    Article  CAS  PubMed  Google Scholar 

  6. Lee IM, Sesso HD, Paffenbarger RS Jr (1999) Physical activity and risk of lung cancer. Int J Epidemiol 28:620–625

    Article  CAS  PubMed  Google Scholar 

  7. Kershaw EE, Flier JSJ (2004) Adipose tissue as an endocrine organ. Clin Endocrinol Metab 6:2548–2556

    Google Scholar 

  8. Brinton LA, Berman ML, Mortel R, Twiggs LB, Barrett RJ, Wilbanks GD, Lannom L, Hoover RN (1992) Reproductive, menstrual, and medical risk factors for endometrial cancer: results from a case-control study. Am J Obstet Gynecol 167:1317–1325

    CAS  PubMed  Google Scholar 

  9. Siiteri PK (1987) Adipose tissue as a source of hormones. Am J Clin Nutr 1:277–282

    Google Scholar 

  10. Fantuzzi G (2005) Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol 115:911–919

    Article  CAS  PubMed  Google Scholar 

  11. Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T (2003) Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 423:762–769

    Article  CAS  PubMed  Google Scholar 

  12. Okamoto Y, Kihara S, Ouchi N, Nishida M, Arita Y, Kumada M, Ohashi K, Sakai N, Shimomura I, Kobayashi H, Terasaka N, Inaba T, Funahashi T, Matsuzawa Y (2002) Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice. Circulation 106:2767–2770

    Article  CAS  PubMed  Google Scholar 

  13. Miyoshi Y, Funahashi T, Kihara S, Taguchi T, Tamaki Y, Matsuzawa Y, Noguchi S (2003) Association of serum adiponectin levels with breast cancer risk. Clin Cancer Res 9:5699–5704

    CAS  PubMed  Google Scholar 

  14. Wei EK, Giovannucci E, Fuchs CS, Willett WC, Mantzoros CS (2005) Low plasma adiponectin levels and risk of colorectal cancer in men: a prospective study. J Natl Cancer Inst 97:1688–1694

    CAS  PubMed  Article  Google Scholar 

  15. Lukanova A, Söderberg S, Kaaks R, Jellum E, Stattin P (2006) Serum adiponectin is not associated with risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev 15:401–402

    Article  CAS  PubMed  Google Scholar 

  16. Diez JJ, Iglesias P (2003) The role of the novel adipocyte-derived hormone adiponectin in human disease. Eur J Endocrinol 148:293–300

    Article  CAS  PubMed  Google Scholar 

  17. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, Hotta K, Shimomura I, Nakamura T, Miyaoka K, Kuriyama H, Nishida M, Yamashita S, Okubo K, Matsubara K, Muraguchi M, Ohmoto Y, Funahashi T, Matsuzawa Y (1999) Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 257:79–83

    Article  CAS  PubMed  Google Scholar 

  18. Hotta K, Funahashi T, Arita Y, Takahashi M, Matsuda M, Okamoto Y, Iwahashi H, Kuriyama H, Ouchi N, Maeda K, Nishida M, Kihara S, Sakai N, Nakajima T, Hasegawa K, Muraguchi M, Ohmoto Y, Nakamura T, Yamashita S, Hanafusa T, Matsuzawa Y (2000) Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 20:1595–1599

    CAS  PubMed  Google Scholar 

  19. Yang WS, Lee WJ, Funahashi T, Tanaka S, Matsuzawa Y, Chao CL, Chen CL, Tai TY, Chuang LM (2002) Plasma adiponectin levels in overweight and obese Asians. Obes Res 10:1104–1110

    Article  CAS  PubMed  Google Scholar 

  20. Karapanagiotou EM, Tsochatzis EA, Dilana KD (2008) The significance of leptin, adiponectin, and resistin serum levels in non-small cell lung cancer. Lung Cancer 61:391–397

    Article  PubMed  Google Scholar 

  21. Kang JH, Yu BY, Youn DS (2007) Relationship of serum adiponectin and resistin levels with breast cancer risk. J Korean Med Sci 22:117–121

    Article  CAS  PubMed  Google Scholar 

  22. Kumor A, Daniel P, Pietruczuk M, Małecka-Panas E (2009) Serum leptin, adiponectin, and resistin concentration in colorectal adenoma and carcinoma (CC) patients. Int J Colorectal Dis 24:275–278

    Article  PubMed  Google Scholar 

  23. Eraslan E, Turkay C, Koktener A, Koca C, Uz B, Bavbek N (2009) Association of visceral fat accumulation and adiponectin levels with colorectal neoplasia. Dig Dis Sci 54:862–868

    Article  CAS  Google Scholar 

  24. Lehrke M, Reilly MP, Millington SC, Iqbal N, Rader DJ, Lazar MA (2004) An inflammatory cascade leading to hyperresistinemia in humans. PLoS Med 1:45

    Article  CAS  Google Scholar 

  25. Weyer C, Funahashi T, Tanaka S, Hotta K, Matsuzawa Y, Pratley RE, Tataranni PA (2001) Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 86:1930–1935

    Article  CAS  PubMed  Google Scholar 

  26. Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS, Lazar MA (2001) The hormone resistin links obesity to diabetes. Nature 409:307–312

    Article  CAS  PubMed  Google Scholar 

  27. Nagaev I, Smith U (2001) Insulin resistance and type 2 diabetes are not related to resistin expression in human fat cells or skeletal muscle. Biochem Biophys Res Commun 285:561–564

    Article  CAS  PubMed  Google Scholar 

  28. TNM classification of malignant tumours. Sobin L.H, Wittekind Ch. Sixth Edition, 2002

  29. Gordon ME, McKeever KH (2005) Diurnal variation of ghrelin, leptin, and adiponectin in standardbred mares. J Anim Sci 10:2365–2371

    Google Scholar 

  30. Yildiz BO, Suchard MA, Wong ML, McCann SM, Licinio J (2004) Alterations in the dynamics of circulating ghrelin, adiponectin, and leptin in human obesity. PNAS 101:10434–10439

    Article  CAS  PubMed  Google Scholar 

  31. Gavrila A, Peng CK, Chan JL, Mietus JE, Goldberger AL, Mantzoros CS (2003) Diurnal and ultradian dynamics of serum adiponectin in healthy men: comparison with leptin, circulating soluble leptin receptor, and cortisol patterns. J Clin Endocrinol Metab 6:2838–2843

    Article  CAS  Google Scholar 

  32. Oliver P, Ribot J, Rodríguez AM, Sánchez J, Picó C, Palou A (2006) Resistin as a putative modulator of insulin action in the daily feeding/fasting rhythm. Pflugers Arch 3:260–267

    Article  CAS  Google Scholar 

  33. McTernan PG, McTernan CL, Chetty R, Jenner K, Fisher FM, Lauer MN, Crocker J, Barnett AH, Kumar S (2002) Increased resistin gene and protein expression in human abdominal adipose tissue. J Clin Endocrinol Metab 87:2407

    Article  CAS  PubMed  Google Scholar 

  34. Trevisan M, Liu J, Muti P, Misciagna G, Menotti A, Fucci F (2001) Risk factors and life expectancy research group. Markers of insulin resistance and colorectal cancer mortality. Cancer Epidemiol Biomarkers Prev 10:937–941

    CAS  PubMed  Google Scholar 

  35. Kelesidis I, Kelesidis T, Mantzoros CS (2006) Adiponectin and cancer: a systematic review. Br J Cancer 94:1221–1225

    Article  CAS  PubMed  Google Scholar 

  36. Bråkenhielm E, Veitonmäki N, Cao R, Kihara S, Matsuzawa Y, Zhivotovsky B, Funahashi T, Cao Y (2004) Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis. Proc Natl Acad Sci U S A 101:2476–2481

    Article  PubMed  CAS  Google Scholar 

  37. Yokota T, Oritani K, Takahashi I, Ishikawa J, Matsuyama A, Ouchi N, Kihara S, Funahashi T, Tenner AJ, Tomiyama Y, Matsuzawa Y (2000) Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. Blood 96:1723–1732

    CAS  PubMed  Google Scholar 

  38. Fujisawa T, Endo H, Tomimoto A, Sugiyama M, Takahashi H, Saito S, Inamori M, Nakajima N, Watanabe M, Kubota N, Yamauchi T, Kadowaki T, Wada K, Nakagama H, Nakajima A (2008) Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition. Gut 57:1531–1538

    Article  CAS  PubMed  Google Scholar 

  39. Ishikawa M, Kitayama J, Kazama S, Hiramatsu T, Hatano K, Nagawa H (2005) Plasma adiponectin and gastric cancer. Clin Cancer Res 11:466–472

    Article  CAS  PubMed  Google Scholar 

  40. Goktas S, Yilmaz MI, Caglar K, Sonmez A, Kilic S, Bedir S (2005) Prostate cancer and adiponectin. Urology 65:1168–1172

    Article  PubMed  Google Scholar 

  41. Mantzoros C, Petridou E, Dessypris N, Chavelas C, Dalamaga M, Alexe DM, Papadiamantis Y, Markopoulos C, Spanos E, Chrousos G, Trichopoulos D (2004) Adiponectin and breast cancer risk. J Clin Endocrinol Metab 89:1102–1107

    Article  CAS  PubMed  Google Scholar 

  42. Ferroni P, Palmirotta R, Spila A, Martini F, Formica V, Portarena I, Del Monte G, Buonomo O, Roselli M, Guadagni F (2007) Prognostic significance of adiponectin levels in non-metastatic colorectal cancer. Anticancer Res 27:483–489

    CAS  PubMed  Google Scholar 

  43. Maeda N, Takahashi M, Funahashi T, Kihara S, Nishizawa H, Kishida K, Nagaretani H, Matsuda M, Komuro R, Ouchi N, Kuriyama H, Hotta K, Nakamura T, Shimomura I, Matsuzawa Y (2001) PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes 9:2094–2099

    Article  Google Scholar 

  44. Reilly MP, Lehrke M, Wolfe ML, Rohatgi A, Lazar MA, Rader DJ (2005) Resistin is an inflammatory marker of atherosclerosis in humans. Circulation 111:932–939

    Article  CAS  PubMed  Google Scholar 

  45. Kawanami D, Maemura K, Takeda N, Harada T, Nojiri T, Imai Y, Manabe I, Utsunomiya K, Nagai R (2004) Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells: a new insight into adipocytokine-endothelial cell interactions. Biochem Biophys Res Commun 314:415–419

    Article  CAS  PubMed  Google Scholar 

  46. Kershaw EE, Flier JS (2004) Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 89:2548–2556

    Article  CAS  PubMed  Google Scholar 

  47. Utzschneider KM, Carr DB, Tong J, Wallace TM, Hull RL, Zraika S, Xiao Q, Mistry JS, Retzlaff BM, Knopp RH, Kahn SE (2005) Resistin is not associated with insulin sensitivity or the metabolic syndrome in humans. Diabetologia 48:2330–2333

    Article  CAS  PubMed  Google Scholar 

  48. Monzillo LU, Hamdy O, Horton ES, Ledbury S, Mullooly C, Jarema C, Porter S, Ovalle K, Moussa A, Mantzoros CS (2003) Effect of lifestyle modification on adipokine levels in obese subjects with insulin resistance. Obes Res 11:1048–1054

    Article  CAS  PubMed  Google Scholar 

  49. Youn BS, Yu KY, Park HJ, Lee NS, Min SS, Youn MY, Cho YM, Park YJ, Kim SY, Lee HK, Park KS (2004) Plasma resistin concentrations measured by enzyme-linked immunosorbent assay using a newly developed monoclonal antibody are elevated in individuals with type 2 diabetes mellitus. J Clin Endocrinol Metab 89:150–156

    Article  CAS  PubMed  Google Scholar 

  50. Shacter E, Weitzman SA (2002) Chronic inflammation and cancer. Oncology 16:217–226

    PubMed  Google Scholar 

Download references

Author information

Affiliations

  1. Department of Medical Oncology, Ondokuz Mayıs University Medical School, Kurupelit, 55139, Samsun, Turkey

    Guzin Gonullu & Idris Yücel

  2. Department of Endocrinology, Ondokuz Mayıs University Medical School, Kurupelit, Samsun, Turkey

    Hakkı Kahraman

  3. Department of Biochemistry, Ondokuz Mayıs University Medical School, Kurupelit, Samsun, Turkey

    Abdulkerim Bedir

  4. Department of Gastroenterology, Ondokuz Mayıs University Medical School, Kurupelit, Samsun, Turkey

    Ahmet Bektas

Authors
  1. Guzin Gonullu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hakkı Kahraman
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Abdulkerim Bedir
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ahmet Bektas
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Idris Yücel
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Guzin Gonullu.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Gonullu, G., Kahraman, H., Bedir, A. et al. Association between adiponectin, resistin, insulin resistance, and colorectal tumors. Int J Colorectal Dis 25, 205–212 (2010). https://doi.org/10.1007/s00384-009-0828-6

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00384-009-0828-6

Keywords

  • Adiponectin
  • Resistin
  • Colon
  • Tumors