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IGR2096a_1 T and IGR2198a_1 C alleles on IBD5 locus of chromosome 5q31 region confer risk for Crohn’s disease in Hungarian patients

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Background and aims

We investigated the possible association of IBD with C1672T of SLC22A4 and G-207C of SLC22A5 alleles, and with the novel IGR2096a_1 (rs12521868) and IGR2198a_1 (rs11739135) susceptibility loci, all located on IBD5 locus of chromosome 5q31.

Materials and methods

DNA of 217 Crohn’s disease, 252 ulcerative colitis, and 290 control patients were analyzed by polymerase chain reaction/restriction fragment length polymorphism methods.

Results

Neither the C1672T and G-207C alleles, nor the TC haplotype were found to be risk factors. By contrast, the minor allele frequencies of IGR2096a_1 T (47.2%) and IGR2198a_1 C (45.9%) were increased in Crohn’s disease compared with the controls (38.2% and 37.7%, respectively; p < 0.05); multivariate regression analysis revealed a risk nature for Crohn’s disease (OR = 1.748, 95% CI 1.186–2.574; p = 0.007 for T allele, OR = 1.646, 95% CI 1.119–2.423, p = 0.011 for C allele of IGRs).

Conclusion

The data suggest a special haplotype arrangement of susceptibility genes at the IBD5 locus in Hungarians, which nation differs historically from the surrounding Caucasian ethnicities in its origin.

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Acknowledgement

This work was supported by the grants of Hungarian Scientific Research Foundation OTKA T 49589 and T 73430, by the grant of the Hungarian Ministry of Health: ETT 497/2006, as well as by the grant of Peter Pazmany Program RET-008/2005.

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Authors and Affiliations

  1. Department of Medicine and Gastroenterology, Markusovszky Hospital, Szombathely, Hungary

    Lilla Lakner

  2. Department of Medical Genetics and Child Development, University of Pécs, Szigeti út 12, Pécs, 7624, Hungary

    Veronika Csöngei, Luca Járomi, Enikő Sáfrány, Lili Magyari, Judit Bene & Béla Melegh

  3. Department of Internal Medicine, University of Pécs, Pécs, Hungary

    Patrícia Sarlós

  4. Department of Medicine and Gastroenterology, Réthy Pál Hospital, Békéscsaba, Hungary

    Márta Varga

  5. Department of Medicine, Borsod-Abaúj-Zemplén County and University Teaching Hospital, Miskolc, Hungary

    Péter Orosz

  6. Department of Medicine, Semmelweis University, Budapest, Hungary

    Pál Miheller & Zsolt Tulassay

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  1. Lilla Lakner
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  2. Veronika Csöngei
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Correspondence to Béla Melegh.

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Lakner, L., Csöngei, V., Sarlós, P. et al. IGR2096a_1 T and IGR2198a_1 C alleles on IBD5 locus of chromosome 5q31 region confer risk for Crohn’s disease in Hungarian patients. Int J Colorectal Dis 24, 503–507 (2009). https://doi.org/10.1007/s00384-009-0670-x

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  • DOI: https://doi.org/10.1007/s00384-009-0670-x

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