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Lipid and phospholipid profile after bowel resection for Crohn’s disease

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Abstract

Background and aim

Chronic inflammation, impaired intestinal adsorption, and bowel resection may have an impact on lipid metabolism before and after intestinal surgery for Crohn’s disease (CD). The aim of this prospective study was to define the impact of intestinal surgery for CD on plasma phospholipid fatty acid (FA) composition and of serum plasma lipoprotein concentrations and to investigate the role of CD recurrence on lipid parameters.

Materials and methods

Twenty-four consecutive patients who had intestinal surgery for CD since December 2004 to March 2006 were enrolled in this prospective study. The total amount of calorie intake and the quality of the aliments, systemic inflammatory activity, and plasma lipoproteins and phospholipid fatty acid composition were determined at operation and at follow-up. Statistical analysis was performed with pair-matched tests.

Results

The median follow-up was 6 (4–20) months. During the follow-up, no significant modification of body mass index was observed. An increase of high-density lipoprotein (HDL) cholesterol (p = 0.02) without other modifications in the plasma phospholipid FA composition were evidenced after surgery. The comparison between colectomy and ileo-colonic or ileal resection groups did not show any significant difference in the lipoprotein concentration and phospholipid FA profile. The length of resected bowel did not show any significant correlation with any relevant difference in lipid, phospholipid profile, or in inflammatory parameters. Patients who experienced a recurrence of CD reported significantly higher levels of total (p < 0.01), HDL (p = 0.01), and low-density lipoprotein cholesterol (p = 0.01) were observed in patients in remission than in those with recurrent active disease.

Conclusions

Patients who are submitted to intestinal resection for CD improve their inflammatory status as well as their lipid metabolism, and CD recurrence, but not the extent of bowel resection, is the main predictor of alteration of serum lipid concentration.

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Acknowledgments

The authors are very grateful to Mrs. Rosa Crecca R.D., for support on dietary intake evaluation and analysis, and to Dr. Federica Limongi PhD (CNR, Institute of Neurosciences, Aging Section, Padova) for her support.

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Authors and Affiliations

  1. Aging Section, CNR-Institute of Neurosciences, via Giustiniani 2, 35128, Padua, Italy

    Giovanna Romanato & Enzo Manzato

  2. Department of Surgical and Gastroenterological Sciences, University of Padova, via Giustiniani 2, 35128, Padua, Italy

    Marco Scarpa, Cesare Ruffolo, Silvia Basato, Teresa Filosa, Fabio Pilon & Imerio Angriman

  3. Department of Medical and Surgical Sciences, University of Padova, via Giustiniani 2, 35128, Padua, Italy

    Raffaella Marin, Sabina Zambon, Silvia Zanoni & Enzo Manzato

Authors
  1. Giovanna Romanato
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  2. Marco Scarpa
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  3. Cesare Ruffolo
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  4. Raffaella Marin
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  5. Sabina Zambon
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  6. Silvia Zanoni
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  7. Silvia Basato
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  8. Teresa Filosa
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  9. Fabio Pilon
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Corresponding author

Correspondence to Giovanna Romanato.

Additional information

Giovanna Romanato and Marco Scarpa contributed equally to the study.

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Romanato, G., Scarpa, M., Ruffolo, C. et al. Lipid and phospholipid profile after bowel resection for Crohn’s disease. Int J Colorectal Dis 23, 931–938 (2008). https://doi.org/10.1007/s00384-008-0503-3

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