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International Journal of Colorectal Disease

, Volume 22, Issue 11, pp 1301–1310 | Cite as

The prognostic factors of stage IV colorectal cancer and assessment of proper treatment according to the patient’s status

  • Hae Ran Yun
  • Woo Yong Lee
  • One Suk Lee
  • Yong Beom Cho
  • Seong Hyeon Yun
  • Ho-Kyung Chun
Original Article

Abstract

Background and aims

Approximately 20% of patients with colorectal cancer are initially diagnosed with stage IV. The majority has non-curative metastases, and their chances of survival are pitiful. This study evaluated the prognostic factors of survival and the access to the effective treatment in accordance with patients.

Materials and methods

We retrospectively analyzed 503 patients for demographics, tumor characteristics, the treatment modality, and the survival outcome. Curative operation was performed in 127 patients and palliative operation in 376 patients.

Results

For the curative operation group, the 5-year survival rate was 34.5%, and the prognostic factors of survival and recurrence were male gender (p = 0.003, 0.009), pathologic N stage (p < 0.001, p = 0.002), and perineural invasion (p = 0.003, p = 0.026), respectively. For the non-curative operation group, the 5-year survival rate was 0%, and the median survival duration was 16.5 months. The potential predictors of survival for the palliative operation group were carcinoembryonic antigen level (p = 0.013), differentiation of tumor (p = 0.011), resection of primary tumor (p < 0.001), and chemotherapy (p < 0.001). But for the 131 patients with asymptomatic incurable disease, only chemotherapy was related to survival (p < 0.001).

Conclusions

The potential predictors of survival for curative stage IV colorectal cancer were male gender, pathologic N stage, and perineural invasion. Resection of the primary tumor and chemotherapy showed benefit for the incurable patients. But for the asymptomatic incurable patients, only chemotherapy prolonged the survival.

Keywords

Stage IV colorectal cancer Resection of primary tumor Chemotherapy 

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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Hae Ran Yun
    • 1
  • Woo Yong Lee
    • 1
    • 2
  • One Suk Lee
    • 1
  • Yong Beom Cho
    • 1
  • Seong Hyeon Yun
    • 1
  • Ho-Kyung Chun
    • 1
  1. 1.Department of Surgery, Samsung Medical CenterSkungkyunkwan University School of MedicineSeoulSouth Korea
  2. 2.SeoulSouth Korea

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