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N-Acetyltransferase (NAT) 2 acetylator status and age of tumour onset in patients with sporadic and familial, microsatellite stable (MSS) colorectal cancer

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Abstract

Introduction

N-Acetyltransferase (NAT) 2 is an important enzyme involved in the metabolism of different xenobiotics, including potential carcinogens. Allelic variants of the NAT2 gene are determined by a pattern of single nucleotide polymorphisms (SNPs) resulting in slow (SA), intermediate (IA) or rapid acetylator (RA) phenotypes and causing the individual differences in the NAT2 metabolic capacity. To clarify the potential modifying role of the NAT2 acetylator status in microsatellite stable (MSS) colorectal cancer (CRC), we studied 140 patients with sporadic CRC (group 1) and 69 patients with CRC who met at least one criterion of the revised Bethesda guidelines (group 2).

Observations

We did not observe any significant difference in the NAT2 acetylator status frequency between patients in both groups and 100 healthy controls (P=0.486). Regardless of a younger median age of tumour onset (AO) of 41 years in group 2 patients compared to 64 years in group 1 patients, no significant difference in AO was found between RA and SA status patients in both groups. The median AO in group 1 was 65 years in patients with RA and 63 years with SA status (P=0.065). The median AO in group 2 was 40 years in patients with RA and 42 years with SA status (P=0.814). Multivariate Cox regression analysis revealed that neither the NAT2 acetylator status (P=0.064 and 0.810, respectively) nor the gender (P=0.165 and 0.918, respectively) was a risk factor for the AO in both groups. These data do not support the hypothesis that the NAT2 acetylatorship acts as a modifying factor on the AO in sporadic and familial, microsatellite stable CRC.

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Acknowledgements

We thank Ms. M. Krenz for the excellent technical assistance and Dr. Alexandre Serra for the preparation of the manuscript.

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Authors and Affiliations

  1. Department of Visceral, Thoracic and Vascular Surgery, University of Technology Dresden, Fetscherstr. 74, 01307, Dresden, Germany

    Steffen Pistorius & Hans-Detlev Saeger

  2. Department of Surgical Research, University of Technology Dresden, Fetscherstr. 74, 01307, Dresden, Germany

    Heike Goergens, Jens Plaschke, Stefan Krueger, Ruth Hoehl & Hans K. Schackert

  3. Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstr. 16-18, 04107, Leipzig, Germany

    Christoph Engel

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  1. Steffen Pistorius
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Correspondence to Steffen Pistorius.

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Pistorius, S., Goergens, H., Engel, C. et al. N-Acetyltransferase (NAT) 2 acetylator status and age of tumour onset in patients with sporadic and familial, microsatellite stable (MSS) colorectal cancer. Int J Colorectal Dis 22, 137–143 (2007). https://doi.org/10.1007/s00384-006-0171-0

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