Skip to main content

Advertisement

Log in

A commentary on the article “Prevalence of the mismatch repair-deficient phenotype in colonic adenomas arising in HNPCC patients—results of a 5-year follow-up study”

  • Invited Commentary
  • Published:
International Journal of Colorectal Disease Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. De Jong AE et al (2004) The role of mismatch repair gene defects in the development of adenomas in patients with HNPCC. Gastroenterology 126(1):42–48

    Article  PubMed  CAS  Google Scholar 

  2. Shia J et al (2005) Value of immunohistochemical detection of DNA mismatch repair proteins in predicting germline mutation in hereditary colorectal neoplasms. Am J Surg Pathol 29(1):96–104

    Article  PubMed  Google Scholar 

  3. Giuffre G et al (2005) Microsatellite analysis of hereditary nonpolyposis colorectal cancer-associated colorectal adenomas by laser-assisted microdissection: correlation with mismatch repair protein expression provides new insights in early steps of tumorigenesis. J Mol Diagn 7(2):160–170

    PubMed  CAS  Google Scholar 

  4. Velayos FS et al (2005) Low rate of microsatellite instability in young patients with adenomas: reassessing the Bethesda guidelines. Am J Gastroenterol 100(5):1143–1149

    Article  PubMed  CAS  Google Scholar 

  5. Umar A et al (2004) Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst 96(4):261–268

    Article  PubMed  CAS  Google Scholar 

  6. Ruschoff J et al (2004) Molecular pathology in hereditary colorectal cancer. Recommendations of the Collaborative German Study Group on hereditary colorectal cancer funded by the German Cancer Aid (Deutsche Krebshilfe). Pathologe 25(3):178–192

    Article  PubMed  CAS  Google Scholar 

  7. Rijcken FE, Hollema H, Kleibeuker JH (2002) Proximal adenomas in hereditary non-polyposis colorectal cancer are prone to rapid malignant transformation. Gut 50(3):382–386

    Article  PubMed  CAS  Google Scholar 

  8. Iacopetta B (2002) Are there two sides to colorectal cancer? Int J Cancer 101(5):403–408

    Article  PubMed  CAS  Google Scholar 

  9. Muller A et al (2004) Challenges and pitfalls in HNPCC screening by microsatellite analysis and immunohistochemistry. J Mol Diagn 6(4):308–315

    PubMed  Google Scholar 

  10. Hemminki A et al (2000) Microsatellite instability is a favorable prognostic indicator in patients with colorectal cancer receiving chemotherapy. Gastroenterology 119(4):921–928

    Article  PubMed  CAS  Google Scholar 

  11. Liang JT et al (2002) High-frequency microsatellite instability predicts better chemosensitivity to high-dose 5-fluorouracil plus leucovorin chemotherapy for stage IV sporadic colorectal cancer after palliative bowel resection. Int J Cancer 101(6):519–525

    Article  PubMed  CAS  Google Scholar 

  12. Meyers M et al (2003) A role for DNA mismatch repair in sensing and responding to fluoropyrimidine damage. Oncogene 22(47):7376–7388

    Article  PubMed  CAS  Google Scholar 

  13. Tajima A et al (2004) The mismatch repair complex hMutS alpha recognizes 5-fluorouracil-modified DNA: implications for chemosensitivity and resistance. Gastroenterology 127(6):1678–1684

    Article  PubMed  CAS  Google Scholar 

  14. Meyers M et al (2005) DNA mismatch repair-dependent response to fluoropyrimidine-generated damage. J Biol Chem 280(7):5516–5526

    Article  PubMed  CAS  Google Scholar 

  15. Müller A et al (2006) Prevalence of the mismatch-repair-deficient phenotype in colonic adenomas arising in HNPCC patients: results of a 5-year follow-up study

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to M. Werner.

Additional information

This commentary refers to the article http://dx.doi.org/10.1007/s00384-005-0073-6

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lassmann, S., Werner, M. A commentary on the article “Prevalence of the mismatch repair-deficient phenotype in colonic adenomas arising in HNPCC patients—results of a 5-year follow-up study”. Int J Colorectal Dis 21, 642–644 (2006). https://doi.org/10.1007/s00384-005-0081-6

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00384-005-0081-6

Keywords

Navigation