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Evaluating toxicity in neoadjuvant radio-chemotherapy of rectal cancer

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References

  1. Sterk P, Keller L, Jochims H, Klein P, Stelzner F, Bruch HP, Markert U (2002) Lymphoscintigraphy in patients with primary rectal cancer: the role of total mesorectal excision for primary rectal cancer—a lymphoscintigraphic study. Int J Colorectal Dis 17:137–142

    Article  PubMed  Google Scholar 

  2. Morgan M, Koorey D, Painter, D Findlay M, Newland R, Chapuis P, Solomon M (2003) p53 and DCC immunohistochemistry in curative rectal cancer surgery. Int J Colorectal Dis 18:188–195

    CAS  PubMed  Google Scholar 

  3. Mulcahy HE, Hyland J, O'Donoghue DP (2003) From dinosaurs to DNA: a history of colorectal cancer. Int J Colorectal Dis 18:210–215

    PubMed  Google Scholar 

  4. Hermanek P, Hohenberger W, Klimpfinger M, Köckerling F, Papadopoulos T (2003) The pathological assessment of mesorectal excision: implications for further treatment and quality management. Int J Colorectal Dis 18:335–341

    PubMed  Google Scholar 

  5. Günther K, Radkow T, Reymond MA, Pflüger R, Dimmler A, Hohenberger W, Papadopoulos T (2003) Angiogenesis and dendritic cell density are not correlated with metachronous distant metastasis in curatively operated rectal cancer. Int J Colorectal Dis 18:300–308

    PubMed  Google Scholar 

  6. Kapiteijn E, Marijnen C, Colenbrander A, Klein Kranenbarg E, Steup W, van Krieken J, van Houwelingen J, Leer J, van de Velde C (1998) Local recurrence in patients with rectal cancer diagnosed between 1988 and 1992: a population-based study in the west Netherlands. Eur J Surg Oncol 24:528–535

    CAS  PubMed  Google Scholar 

  7. Kapiteijn E, Marijnen C, Nagtegaal I, Putter H, Steup W, Wiggers T, Rutten H, Pahlman L, Glimelius B, van Krieken J, Leer J, van de Velde C (2001) Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med 345:638–646

    Google Scholar 

  8. Tepper J, O'Connell M, Niedzwiecki D, Hollis D, Benson A, Cummings B, Gunderson L, Macdonald J, Martenson J, Mayer R (2002) Adjuvant therapy in rectal cancer: analysis of stage, sex, and local control—final report of Intergroup 0114. J Clin Oncol 20:1744–1750

    Article  CAS  PubMed  Google Scholar 

  9. Wolmark N, Wieand H, Hyams D, Colangelo L, Dimitrov N, Romond E, Wexler M, Prager D, Cruz A, Gordon P, Petrelli N, Deutsch M, Mamounas E, Wickerham D, Fisher E, Rockette H, Fisher B (2000) Randomized trial of postoperative adjuvant chemotherapy with or without radiotherapy for carcinoma of the rectum: National Surgical Adjuvant Breast and Bowel Project Protocol R-02. J Natl Cancer Inst 92:388–396

    Article  CAS  PubMed  Google Scholar 

  10. Rudzki Z, Zazula M, Okon' K, Stachura J (2002) Colorectal carcinoma in Poland in 1975 and 1995: not only more, but also different. Int J Colorectal Dis 17:161–170

    Google Scholar 

  11. NIH Consensus Conference (1990) Adjuvant therapy for patients with colon and rectal cancer. JAMA 264:1444–1450

    PubMed  Google Scholar 

  12. Gastrointestinal Tumor Study Group (1985) Prolongation of the disease free interval in surgically treated rectal carcinoma. N Engl J Med 312:1465–1472

    PubMed  Google Scholar 

  13. Krook J, Moertel C, Gunderson L, Wieand H, Collins R, Beart R, Kubista T, Poon M, Meyers W, Mailliard J, Twito D, Morton R, Veeder M, Witzig T, Cha S, Vidyarthi S (1991) Effective surgical adjuvant therapy for high risk rectal carcinoma. N Engl J Med 324:709–715

    Google Scholar 

  14. Ayanian J, Zaslavsky A, Fuchs C, Guadagnoli E, Creech C, Cress R, O'Conner L, West D, Allen M, Wolf R, Wright W (2003) Use of adjuvant chemotherapy and radiation therapy for colorectal cancer in a population-based cohort. J Clin Oncol 21:1293–1300

    Article  PubMed  Google Scholar 

  15. Valero G, Lujan JA, Hernandez Q, de las Heras M, Pellicer E, Serrano A, Parilla P (2003) Neo-adjuvant radiation and chemotherapy in rectal cancer does not increase postoperative complications. Int J Colorectal Dis (http://dx.doi.org/10.1007/s00384-003-0520-1)

  16. Crane CH, Skibber JM, Feig BW, Vauthey JN, Curley SA, Rodriguez-Bigas MA ; Wolff RA, Ellis LM, Delclos ME, Lin EH, Janjan NA (2003) Response to preoperative chemoradiation increases the use of sphinkter-preserving surgery in patients with locally advanced low rectal carcinoma. Cancer 97:517–524

    Article  PubMed  Google Scholar 

  17. Gerard JP, Chapet O, Nemoz C, Romestaing P, Mornex F, Coquard R, Barbet N, Atlan D, Adeleine P, Freyer G (2003) Preoperative concurrent chemoradiation in locally advanced rectal cancer with high-dose radiation and oxaliplatin containing regimen: the Lyon R0-04 Phase II Trial. J Clin Oncol 21:1119–1124

    Article  PubMed  Google Scholar 

  18. O'Connell M, Martenson J, Wieand H, Krook J, Macdonald J, Haller D, Mayer R, Gunderson L, Rich T (1994) Improving adjuvant therapy for rectal cancer by combining protracted-infusion fluorouracil with radiation therapy after curative surgery. N Engl J Med 331:502–507

    Google Scholar 

  19. Hyams DM, Mamounas EP, Petrelli N, Rockette H, Jones J, Wieand HS, Deutsch M, Wickerham L, Fisher B, Wolmark N (1997) A clinical trial to evaluate the worth of preoperative multimodality therapy in patients with operable carcinoma of the rectum: a progress report of the National Surgical Adjuvant Breast and Bowel Project R-03. Dis Colon Rectum 40:131–139

    CAS  PubMed  Google Scholar 

  20. Camma' C, Giunta M, Fiorica F, Pagliaro L, Craxı' A, Cottone M (2000) Preoperative radiotherapy for resectable rectal cancer. A meta-analysis. JAMA 284:1008–1015

    PubMed  Google Scholar 

  21. Colorectal Cancer Collaborative Group (2001) Adjuvant radiotherapy for rectal cancer: a systematic overview of 8507 patients from 22 randomised trials. Lancet 358:1291–1304

    Article  PubMed  Google Scholar 

  22. Eifel P, Jhingran A, Bodurka DC, Levenback C, Thames H (2002) Correlation of smoking history and other patient characteristics with major complications of pelvic radiation therapy for cervical cancer. J Clin Oncol 20:3651–3657

    Article  PubMed  Google Scholar 

  23. Merkel S, Mansmann U, Siassi M, Papadopoulos T, Hohenberger W, Hermanek P (2001) The prognostic inhomogeneity in pT 3 rectal carcinomas. Int J Colorectal Dis 16:298–304

    Google Scholar 

  24. Marusch F, Koch A, Schmidt U, Zippel R, Gastmeier J, Ludwig K, Geißler S, Pross M, Gastinger I, Lippert H (2002) Impact of age on the short-term postoperative outcome of patients undergoing surgery for colorectal carcinoma. Int J Colorectal Dis 17:177–184

    Google Scholar 

  25. Dahlberg M, Stenborg A, Pahlman L, Glimelius B (2002) Cost-effectiveness of preoperative radiotherapy in rectal cancer: results from the Swedish Rectal Cancer Trial. Int J Radiat Oncol Biol Phys 54:654–660

    Article  PubMed  Google Scholar 

  26. Vincenzo Violi V, Boselli AS, De Bernardinis M, Costi R, Trivelli M, Roncoroni L (2002) A patient-rated, surgeon-corrected scale for functional assessment after total anorectal reconstruction. An adaptation of the Working Party on Anal Sphincter Replacement scoring system. Int J Colorectal Dis 17:327–337

    Article  PubMed  Google Scholar 

  27. Kim NK, Lim DJ, Yun SH, Sohn SK, Min SJ (2001) Ultralow anterior resection and coloanal anastomosis for distal rectal cancer: functional and oncological results. Int J Colorectal Dis 16:234–237

    CAS  PubMed  Google Scholar 

  28. Palmer BV, Lockley WL, Palmer RB, Kulinskaya E (2002) Improvement in irritable bowel syndrome following ano-rectal surgery. Int J Colorectal Dis 17:402–411

    Article  PubMed  Google Scholar 

  29. Ho P, Law WL, Chan SC, Lam CK, Chu KW (2003) Functional outcome following low anterior resection with total mesorectal excision in the elderly. Int J Colorectal Dis 18:230–233

    PubMed  Google Scholar 

  30. Gelber R, Goldhirsch A, Cole B, Wieand H, Schroeder G, Krook J (1996) A quality-adjusted time without symptoms or toxicity (Q-TWiST) analysis of adjuvant radiation therapy and chemotherapy for resectable rectal cancer. J Natl Cancer Inst 88:1039–1045

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Radiation Oncology and Radiotherapy, Benjamin Franklin Medical Center, Freie Universität Berlin, Hindenburgdamm 30, 12200, Berlin, Germany

    Stefan Höcht

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  1. Stefan Höcht
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Correspondence to Stefan Höcht.

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This commentary refers to the article http://dx.doi.org/10.1007/s00384-003-0520-1

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Höcht, S. Evaluating toxicity in neoadjuvant radio-chemotherapy of rectal cancer. Int J Colorectal Dis 18, 500–502 (2003). https://doi.org/10.1007/s00384-003-0521-0

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  • DOI: https://doi.org/10.1007/s00384-003-0521-0

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