Abstract
Background and aims
Neoadjuvant radiation and chemotherapy in rectal cancer reduces local recurrences and increases the rate of conservative sphincter surgery. However, an increase in postoperative morbidity and mortality has also been observed. This study analyzed the operative difficulty and postoperative complications in patients with this treatment.
Patients and methods
Retrospective review of 103 patients with rectal cancer, divided into two groups: group A, 53 patients undergoing preoperative radiotherapy with 45 Gy combined with chemotherapy, and group B, 50 patients with rectal cancer who received surgery after diagnosis. Both groups were homogeneous. The two groups were compared for both technical difficulty, using intraoperative data and rate of complications.
Results
There were no statistically significant differences between the two groups with regard to intraoperative or postoperative data. In group A there were 20 complications in 17 patients (32%) and in group B 22 complications in 19 patients (38%). The rates of perineal wound infection were similar. The percentage of anastomotic leaks was higher in group A. A greater number of anterior resections was performed in group A.
Conclusion
Preoperative radiation and chemotherapy in rectal cancer does not increase postoperative complications and increases the rate of sphincter-preserving surgery.
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Acknowledgements
This research was supported in part by grant 00724/CV/99 from Proyecto Seneca.
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An invited commentary on this paper is available at http://dx.doi.org/10.1007/s00384-003-0521-0
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Valero, G., Luján, J.A., Hernández, Q. et al. Neoadjuvant radiation and chemotherapy in rectal cancer does not increase postoperative complications. Int J Colorectal Dis 18, 495–499 (2003). https://doi.org/10.1007/s00384-003-0520-1
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DOI: https://doi.org/10.1007/s00384-003-0520-1