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Excessive alcohol intake enhances the development of synchronous cancerous lesion in colorectal cancer patients

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Abstract

Background and aims

We examined the potential impact of alcohol drinking on the incidence of synchronous colorectal cancer.

Patients and methods

This study comprised 191 men with colorectal cancer who had undergone surgical resection. Synchronous colorectal cancer was found in 16 patients (8.4%). The relationship between synchronous colorectal cancer and alcohol intake was analyzed by multivariate methods. Cumulative alcohol intake was assessed by the drinking index (weekly average multiplied by years of drinking).

Results

There was higher incidence of associated adenoma in the synchronous cancer group. Heavy cumulative intake (drinking index 9800 or higher) was associated with significantly higher risk synchronous colorectal cancer than in nondrinkers (odds ratio 6.8). The association of alcohol intake with the risk of synchronous colorectal cancer was not affected by the type of alcohol beverages.

Conclusion

This study demonstrated that excessive alcohol intake might be an independent risk factor for synchronous colorectal cancer. The screening program based on this information may prevent the synchronous lesions being missed.

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Authors and Affiliations

  1. Division of Diabetes, Digestive, and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Hyogo, 650-0017, Kobe, Japan

    Shu-ji Maekawa, Daisuke Shirasaka, Takao Tamura & Masato Kasuga

  2. Department of Endoscopy, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Hyogo, 650-0017, Kobe, Japan

    Nobuo Aoyama & Kohei Kuroda

  3. Division of Gastroenterolgical Surgery, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Hyogo, 650-0017, Kobe, Japan

    Yoshikazu Kuroda

Authors
  1. Shu-ji Maekawa
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  2. Nobuo Aoyama
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  3. Daisuke Shirasaka
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  4. Kohei Kuroda
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  5. Takao Tamura
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  6. Yoshikazu Kuroda
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  7. Masato Kasuga
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Correspondence to Nobuo Aoyama.

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Maekawa, Sj., Aoyama, N., Shirasaka, D. et al. Excessive alcohol intake enhances the development of synchronous cancerous lesion in colorectal cancer patients. Int J Colorectal Dis 19, 171–175 (2004). https://doi.org/10.1007/s00384-003-0516-x

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  • DOI: https://doi.org/10.1007/s00384-003-0516-x

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