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Systematic review of the mechanism and assessment of liver fibrosis in biliary atresia

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Abstract

Purpose

This study systematically reviewed our team’s research on the mechanism and assessment of liver fibrosis in BA, summarized our experience, and discussed the future development direction.

Methods

In this study, Pubmed and Wanfang databases were searched to collect the literature published by our team on the mechanisms of liver fibrosis in BA and the assessment of liver fibrosis in BA, and the above research results were systematically reviewed.

Results

A total of 58 articles were retrieved. Among the included articles, 25 articles related to the mechanism of liver fibrosis in BA, and five articles evaluated liver fibrosis in BA. This article introduces the key pathways and molecules of liver fibrosis in BA and proposes a new grading system for liver fibrosis in BA.

Conclusions

The new BA liver fibrosis grading method is expected to assess children’s conditions, guide treatment, and improve prognosis more accurately. In addition, we believe that the TGF-β1 signaling pathway is the most important in the study of liver fibrosis in BA, and at the same time, the study of EMT occurrence in BA should also be deepened to resolve the controversy on this issue.

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Data availability

No datasets were generated or analyzed during the current study.

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Acknowledgements

Funding by Tianjin Key Medical Discipline (Specialty) Construction Project, the Tianjin Science and Technology Program (No.21ZXGWSY00070) and the Tianjin Applied Basic Research Project (No.22JCZDJC00290).

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Authors and Affiliations

  1. Tianjin Children’s Hospital (“Children’s Hospital, Tianjin University”), Tianjin, China

    Jianghua Zhan, Shaowen Liu, Yu Meng, Qianhui Yang, Zhiru Wang, Shujian Zhang, Liang Ge, Li Zhao, Xiaodan Xu, Yilin Zhao, Xin Li & Xueting Wang

  2. Tianjin Key Laboratory of Birth Defects for Prevention and Treatment, Tianjin, China

    Jianghua Zhan, Shaowen Liu, Yu Meng, Qianhui Yang, Zhiru Wang, Shujian Zhang, Liang Ge, Li Zhao, Xiaodan Xu, Yilin Zhao, Xin Li & Xueting Wang

  3. Department of General Surgery, Tianjin Children’s Hospital, 238 Longyan Road, Beichen District, Tianjin, 300134, China

    Jianghua Zhan, Shaowen Liu, Yu Meng, Qianhui Yang, Zhiru Wang, Shujian Zhang, Liang Ge, Xiaodan Xu, Yilin Zhao, Xin Li & Xueting Wang

  4. Clinical School of Paediatrics, Tianjin Medical University, Tianjin, China

    Shaowen Liu, Yu Meng, Qianhui Yang, Zhiru Wang, Xiaodan Xu, Yilin Zhao, Xin Li & Xueting Wang

  5. Department of Pathology, Tianjin Children’s Hospital, Tianjin, China

    Li Zhao

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  1. Jianghua Zhan
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Contributions

Conception and design: Jianghua Zhan, Shaowen Liu; administrative support: Jianghua Zhan; drawing of figures: Qianhui Yang; data extraction: Shaowen Liu, Yu Meng, Qianhui Yang; manuscript writing: all authors. All authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Jianghua Zhan.

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Zhan, J., Liu, S., Meng, Y. et al. Systematic review of the mechanism and assessment of liver fibrosis in biliary atresia. Pediatr Surg Int 40, 205 (2024). https://doi.org/10.1007/s00383-024-05778-x

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