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Mortality and neurodevelopmental outcomes in very low birth weight infants with esophageal atresia

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Abstract

Purpose

Very low birth weight infants (VLBWIs) have been thought as risk of bad outcomes in the patients with esophageal atresia (EA). However, detailed outcomes of EA within VLBWIs were not fully understood. We aimed to reveal short- and long-term outcomes in VLBWIs with EA.

Methods

Clinical data regarding VLBWIs with EA registered in Neonatal Research Network Japan, a multicenter research database in Japan, were collected. Patients with chromosomal abnormality were excluded. Short term outcome was survival discharge from NICU and long-term outcome was neurodevelopmental impairment (NDI) at 3 years.

Results

A total of 103 patients were analyzed. the overall survival discharge rate from NICU was 68.0% (70/103). The risk of death was increased as the birth weight got reduced. The presence of associated anomaly increased the risk of death. Three-year neurodevelopmental information was available in 32.9% (23/70) of patients. Of the 23 included patients for 3-year follow-up, 34.8% had NDI. The risk of NDI was increased as the birth weight reduced.

Conclusions

In VLBWIs with EA, survival discharge from NICU was still not high. More immature patients and patients with an associated anomaly had worse outcomes. Among patients who survived, NDI was confirmed in a certain number of patients.

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Data availability

The data that support the findings of this study are available from the corresponding author, H.M., upon reasonable request.

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Acknowledgements

The authors appreciate members of the Neonatal Research Network of Japan, and the investigators of the participating institutions.

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Authors and Affiliations

  1. Department of Pediatric Surgery, Shizuoka Children’s Hospital, 860 Urushiyama, Aoi-ku, Shizuoka, 4208660, Japan

    Hiromu Miyake

  2. Shizuoka Graduate University of Public Health, Shizuoka, Japan

    Hiromu Miyake, Seiichiro Yamamoto & Hatoko Sasaki

  3. Department of Neonatology, Shizuoka Children’s Hospital, Shizuoka, Japan

    Reiji Nakano

  4. Division of Neonatology, Center of Maternal-Fetal Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan

    Tetsuya Isayama

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  1. Hiromu Miyake
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  2. Reiji Nakano
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  4. Tetsuya Isayama
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  5. Hatoko Sasaki
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on behalf of the Neonatal Research Network of Japan

Contributions

HM and HS designed the study. HM and SY collected and analyzed data. HM wrote the main manuscript. RN and TI contributed to refine study concept and design. All authors critically reviewed the manuscript.

Corresponding author

Correspondence to Hiromu Miyake.

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The authors have no conflicts of interest to disclose.

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Miyake, H., Nakano, R., Yamamoto, S. et al. Mortality and neurodevelopmental outcomes in very low birth weight infants with esophageal atresia. Pediatr Surg Int 39, 294 (2023). https://doi.org/10.1007/s00383-023-05579-8

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