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Clinical evaluation of transcatheter arterial embolization combined with propranolol orally treatment of infantile hepatic hemangioma

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Abstract

Purpose

To assess the efficacy of transcatheter arterial embolization (TAE) plus propranolol treatment for infantile hepatic hemangioma (IHH).

Methods

A retrospective study of symptomatic IHH and hemodynamic changes in IHH was conducted between 2016 and 2019.

Results

There were five boys and seven girls with diffuse lesions (n = 7) and multifocal lesions (n = 5). Hepatomegaly and abdominal distension (n = 6) were the predominant clinical presentations. Seven patients (58.3%) had multiple cutaneous hemangiomas. Pulmonary arterial hypertension, heart failure (n = 4), and hypothyroidism (n = 4) were observed. A total of 17 TAE procedures were performed in 12 IHH cases, with a technical success rate of 100%. All patients received standard propranolol orally, and one patient was orally administered metacortandracin. Two patients died of heart failure and multiple organ dysfunction caused by an enlarged liver. In addition, one patient was not reexamined after discharge. Of the remaining nine children, the average follow-up time was 10.78 months (range 2–28 months), and they all responded well to TAE combined with oral propranolol.

Conclusion

TAE combined with propranolol is safe and effective for the treatment of IHH, demonstrating low complication rates.

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Acknowledgements

I would particularly like to acknowledge my team members for their wonderful collaboration and patient support. We would like to thank Editage (www.editage.cn) for English language editing.

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Authors and Affiliations

  1. Department of Vascular Anomalies and Interventional Radiology, Children’s Hospital Affiliated to Shandong University Ji’nan Children’s Hospital, Jinan, China

    Liang Wang, Jing Li, Dan Song & Lei Guo

  2. Department of Vascular Anomalies and Interventional Radiology, Ji’nan Children’s Hospital, Jinan, China

    Liang Wang, Jing Li, Dan Song & Lei Guo

Authors
  1. Liang Wang
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  2. Jing Li
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  3. Dan Song
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  4. Lei Guo
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All authors made substantial contributions to conception and design, or acquisition of data, or analysis and interpretation of data; drafted the article or revised it critically for important intellectual content; and made final approval of the version to be published.

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Correspondence to Lei Guo.

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The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Wang, L., Li, J., Song, D. et al. Clinical evaluation of transcatheter arterial embolization combined with propranolol orally treatment of infantile hepatic hemangioma. Pediatr Surg Int 38, 1149–1155 (2022). https://doi.org/10.1007/s00383-022-05143-w

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  • DOI: https://doi.org/10.1007/s00383-022-05143-w

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