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Computer-aided quantitative MSCT measurements may be useful for congenital lung malformations surgical approach selection

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Abstract

Purpose

To examine the association between the MSCT quantitative measurements of congenital lung malformations (CLM) and the selection of surgical approaches (lobectomy vs. lung-sparing surgery).

Methods

This retrospective study evaluated CLM surgical cases at our institution from 2016 to 2018. MSCT quantitative measurements were generated by a semi-automated approach: the volume of the lesion (Vlesion), the volume of the lesion-involved lobe (Vlobe), the volume of the lesion-involved lung (Vlung) and the volume of the total lung (Vtotal lung). The proportions of Vlesion to Vlobe (Plesion/lobe), Vlesion to Vlung (Plesion/lung), and Vlesion to V total lung (Plesion/total lung) were calculated. We used Logistics regression to examine whether quantitative measurements were associated with the selection of surgical approaches.

Results

151 patients were included (median age at surgery 6 months). 82 patients underwent lung-sparing surgery, and 69 patients underwent lobectomy. Vlesion (OR 1.51, 95% CI 1.09–2.07), Plesion/lobe (OR 1.78, 95% CI 1.16–2.72), Plesion/lung (OR 1.63, 95% CI 1.13–2.35), and Plesion/total lung (OR 1.58, 95% CI 1.12–2.22) were positively associated with the selection of lobectomy.

Conclusion

The application of quantified MSCT analysis may provide insight into the quantitative characteristics of CLM, which could be potentially useful for surgical approach selection.

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Acknowledgements

We would like to thank Dr. Xiaoqian Zhou for her help with image data collection. We also appreciated Dr. Lirong Wang’s advice on data management and statistical analysis.

Funding

This work was supported by funding from the Public Science and Technology research funds of China (No. 201402013) and the Shaanxi Key Research and Development Program (No. 2018SF-220).

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Author notes

  1. Weili Yang and Cong Shen contributed equally to this work.

Authors and Affiliations

  1. Department of Pediatric Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, 157 West Five Road, Xi′an, 710004, Shaanxi, China

    Weili Yang, Weikang Pan, Peng Li, Ya Gao & Jiwen Cheng

  2. Department of Medical Imaging, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, Shaanxi, China

    Cong Shen & Youmin Guo

  3. Department of Medical Imaging, The Affiliated Hospital of Shaanxi Chinese Medicine University, Xianyang, 712000, Shaanxi, China

    Nan Yu

  4. Department of Medical Imaging, The Second Affiliated Hospital of Xi’an Jiaotong University, 157 West Five Road, Xi′an, 710004, Xi′an, China

    Xin Chen

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  1. Weili Yang
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Correspondence to Xin Chen or Jiwen Cheng.

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Yang, W., Shen, C., Yu, N. et al. Computer-aided quantitative MSCT measurements may be useful for congenital lung malformations surgical approach selection. Pediatr Surg Int 37, 1273–1280 (2021). https://doi.org/10.1007/s00383-021-04949-4

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