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Long-term outcomes of various pediatric short bowel syndrome in China

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Abstract

Purpose

The goal of this study was to analyze long-term outcome of various pediatric short bowel syndrome (SBS) at an intestinal rehabilitation center in China.

Methods

One hundred and fifty-seven children with SBS were enrolled in this study from October 1988 to July 2019. Their long-term follow-up outcome was analyzed according to the age of disease onset, parenteral nutrition (PN) duration, and anatomic types of short bowel, respectively. The clinical characteristics, which included demographics, the length of residual small bowel, PN duration, PN dependence, SBS-related complications such as IF-related liver disease (IFALD), catheter-related bloodstream infection (CRBI), and mortality were compared among the groups.

Results

The main etiology for SBS were intestinal atresia, NEC, and volvulus. Five of 157 patients did not wean off PN. The incidence of IFALD and CRBI was 24.2 and 22.3%, respectively. Sixteen cases died because of infection and liver failure and eight patients lost to follow-up. The survival rate of the 157 patients was 84.7%. PN duration was longer in the infants and children group (284 ± 457 d vs. 110 ± 64 d, P = 0.021; R = 0.264, P = 0.001) and more patients did not wean off PN than in the neonates group (11.6% vs. 0, P = 0.001; R = 0.295, P < 0.001). Patients with PN with a duration of longer than 90 days had more CRBIs (30.6%, P = 0.025; R = 0.236, P = 0.003). Additionally, the rate of CRBI was higher in patients with stoma (30.0%, P = 0.032). There was no difference in mortality among the groups. In five PN dependence patients, none was SBS onset in neonates.

Conclusion

Pediatric patients with SBS could achieve favorable long-term survival and enteral autonomy. Different standards of SBS classification such as the age of disease onset, PN duration, and anatomic types of short bowel did not impact the overall mortality of pediatric SBS. Prolonged PN duration positively correlated with the age of disease onset and the incidence of CRBI. Patients with the complete continuity of intestinal tract suffered less from CRBI.

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Acknowledgments

The authors wish to thank the subjects and their parents who participated in this study and the nurses at the Department of Pediatric Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine.

Funding

This work was supported by Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition (17DZ2272000); and the National Natural Science Foundation of China-Key Program (81630039).

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Author notes

  1. Tian Zhang and Haixia Feng were contributed equally to this work.

Authors and Affiliations

  1. Department of Pediatric Surgery, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

    Tian Zhang & Wei Cai

  2. Division of Pediatric GI and Nutrition, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

    Haixia Feng, Yi Cao, Yijing Tao, Lina Lu, Weihui Yan & Ying Wang

  3. Department of Pharmacy, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

    Fang Li

  4. Shanghai Institute for Pediatric Research, Shanghai, China

    Tian Zhang, Haixia Feng, Yi Cao, Yijing Tao, Lina Lu, Weihui Yan, Fang Li, Ying Wang & Wei Cai

  5. Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, China

    Tian Zhang, Haixia Feng, Yi Cao, Yijing Tao, Lina Lu, Weihui Yan, Fang Li, Ying Wang & Wei Cai

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  1. Tian Zhang
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Zhang, T., Feng, H., Cao, Y. et al. Long-term outcomes of various pediatric short bowel syndrome in China. Pediatr Surg Int 37, 495–502 (2021). https://doi.org/10.1007/s00383-020-04797-8

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