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The G178A polymorphic variant of INSL3 may be linked to cryptorchidism among Egyptian pediatric cohort

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A Correction to this article was published on 21 September 2020

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Abstract

Cryptorchidism (CO) is a genital disorder of multifactorial etiology, with serious remote complications. Mutations in insulin-like 3 hormones (INSL3) G/A variant remain a matter of inquiry. We aimed to investigate the association between G178A-INSL3 polymorphism and undescended testis in a cohort of Egyptian children. In this study, a total of 160 children, including 80 cases with primary non-syndromic undescended testes and 80 healthy children with normal external genitalia as controls, both, were analyzed after detailed history, physical examination and imaging for mutations of G178A polymorphism of INSL3 gene by restriction fragment length polymorphism (RFLP) technique. We found most of the undescended testes were inside the inguinal canal mainly on the left side. Genetic analysis revealed that the mutant A allele of G178A INSL3 variant was significantly detected in the patient group with a frequency of 26.2% against 12.5% for control subjects, especially among cases with an evident family history of similar cases as shown by p value = 0.001 and odd's ratio (CI95%) of 0.13 (0.04–0.723). In conclusion, G178A—INSL3 gene polymorphism could be a susceptibility factor for testicular maldescent in Egyptian children. Also, family history of similar cases was considered as significant predictive risk for cryptorchidism, added to the shared genetic links to consanguinity in our locality.

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  • 21 September 2020

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Authors and Affiliations

  1. Genetic and Endocrinology Unit, Pediatric Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt

    Sohier S. Abou EL-Ella, Maha Atef Tawfik & Naglaa Fathy Barseem

  2. Department of Pediatric Surgery, Menoufia University, Menoufia, Egypt

    Tamer Fakhry Abd El-Aziz

  3. Faculty of Medicine, Menoufia University, Menoufia, Egypt

    Ahmed Mohammed Ahmed Shalaby

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  1. Sohier S. Abou EL-Ella
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  2. Maha Atef Tawfik
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  3. Tamer Fakhry Abd El-Aziz
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  5. Naglaa Fathy Barseem
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Correspondence to Naglaa Fathy Barseem.

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Abou EL-Ella, S.S., Tawfik, M.A., Abd El-Aziz, T.F. et al. The G178A polymorphic variant of INSL3 may be linked to cryptorchidism among Egyptian pediatric cohort. Pediatr Surg Int 36, 1387–1393 (2020). https://doi.org/10.1007/s00383-020-04735-8

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