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Melanoma in children, adolescents and young adults: anatomo-clinical features and prognostic study on 426 cases

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Abstract

Purpose

This study was conducted to determine the difference in anatomo-pathological and prognostic features of cutaneous melanoma in children, adolescents and young adults.

Methods

This is a retrospective review on 383 young patients ≤ 39 years of age with cutaneous melanoma, in a period from 2006 to 2016 in Area Vasta Nord Ovest, Tuscany, Italy. We subdivided patients in three groups (children ≤ 14 years, adolescents 15–21 years, young adults 22–39 years). We correlated all the anatomo-pathological parameters with age groups.

Results

We identified a total of 426 cases of cutaneous melanoma on an overall total of 383 patients. Mean age at diagnosis for all the patients ≤ 39 years of age was 31.2 years: in group A was 11.2 years, in group B 19.2 years and in group C 32.5 years. Incidence, in the subjects between 0 and 14 years, is 14 cases per million inhabitants, between 15 and 21 years of 145, and between 22 and 39 years of 394. Global incidence was 1.6 case per million for group A, 8.9 cases per million for group B, 105 cases per million for group C. No statistically significative correlation could be described for clinical parameters and age groups.

Conclusions

Incidence of melanoma in our casuistry results as the highest in the world. These data open new study for this kind of cancer.

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Author information

Authors and Affiliations

  1. Melanoma and Skin Cancer Unit AVNO (Area Vasta Nord Ovest) and Unit of Dermatology, Livorno Hospital, Livorno, Italy

    Giovanni Bagnoni, Cristian Fidanzi & Angelo Massimiliano D’Erme

  2. Unit of Pathology, Livorno Hospital, Livorno, Italy

    Paolo Viacava

  3. Pediatric, Adolescent and Young Adults Surgery Division, Department of Surgical, Medical, Pathological, Molecular and Critical Area, University of Pisa, Pisa, Italy

    Matteo Leoni, Silvia Strambi, Chiara Calani, Alessia Bertocchini & Claudio Spinelli

  4. Statistical Support to Clinical Trials Department, University of Pisa, Pisa, Italy

    Riccardo Morganti

Authors
  1. Giovanni Bagnoni
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  2. Cristian Fidanzi
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Corresponding author

Correspondence to Claudio Spinelli.

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Bagnoni, G., Fidanzi, C., D’Erme, A.M. et al. Melanoma in children, adolescents and young adults: anatomo-clinical features and prognostic study on 426 cases. Pediatr Surg Int 35, 159–165 (2019). https://doi.org/10.1007/s00383-018-4388-0

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  • DOI: https://doi.org/10.1007/s00383-018-4388-0

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