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Comparison of long-term prognosis of laparoscopic and open adrenalectomy for local adrenal neuroblastoma in children

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Abstract

Objective

To investigate and compare long-term outcomes in children undergoing laparoscopic or open adrenalectomy for local adrenal neuroblastoma.

Methods

A retrospective review was conducted of 37 children with local adrenal neuroblastoma treated between January 2005 and December 2013 in our hospital. These patients met inclusion criteria for having adrenal neuroblastoma and undergoing operative resection. All patients were successfully followed up until December 2017.

Results

The local adrenal neuroblastoma cases included 25 males and 12 females with an average age of 37.24 ± 37.55 months (range from 5 days to 158 months). Left adrenal lesions were present in 13 cases, the right in 24 cases. According to the INSS staging system, 27 patients were classified as stage I and 10 as stage II. Open adrenalectomy was performed in 24 patients. Laparoscopic adrenalectomy was performed in the other 13 patients, 2 of whom were converted to open surgery because of adhesions to renal vessels and diaphragmatic rupture. Significant differences were observed between the laparoscopic surgery and open surgery groups regarding tumor size (P = 0.005). There were two recurrence cases in open surgery, but there was no recurrence in laparoscopic surgery. The average follow-up time was 86.78 ± 24.52 months. The overall 5-year survival rate of open and laparoscopic surgery were 86.2 and 100% (P = 0.316).

Conclusions

Laparoscopic adrenalectomy for neuroblastoma is feasible and can be performed with equivalent recurrence and mortality rates with open resection. For small tumor size and absence of vascular encasement, the adrenal neuroblastoma may be preferred laparoscopic surgery.

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Authors and Affiliations

  1. Department of Pediatric Surgery, Children’s Hospital of Fudan University, 399 Wanyuan Road, Shanghai, China

    Wei Yao, Kuiran Dong, Kai Li, Shan Zheng & Xianmin Xiao

Authors
  1. Wei Yao
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  2. Kuiran Dong
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  3. Kai Li
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  4. Shan Zheng
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  5. Xianmin Xiao
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Corresponding author

Correspondence to Kuiran Dong.

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All authors of this article had no conflict of interest.

Research involving human participants and/or animals

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Yao, W., Dong, K., Li, K. et al. Comparison of long-term prognosis of laparoscopic and open adrenalectomy for local adrenal neuroblastoma in children. Pediatr Surg Int 34, 851–856 (2018). https://doi.org/10.1007/s00383-018-4294-5

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  • DOI: https://doi.org/10.1007/s00383-018-4294-5

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