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Comparative outcomes in intestinal atresia: a clinical outcome and pathophysiology analysis

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Abstract

Objective

To describe the outcomes of 130 intestinal atresias between 1982 and 2007.

Methods

Records were analyzed for location, demographics, prenatal diagnosis, birth weight, associated anomalies, surgery, establishment of oral intake, re-interventions and mortality. Statistical analyses were performed using Fisher test and ANOVA.

Results

There were 59 duodenal (30 male), 63 jejuno-ileal (34 male) and 8 colonic atresias (3 male). Prenatal diagnosis was established in 27 (46%) duodenal (DA), 26 (41%) jejuno-ileal (JIA) and 1 (12.5%) colonic atresias (CA). The mean birth weights, 2,380.5 g (SD 988) DA, 2,814 g (SD 755) JIA and 3,153 g (SD 527) CA were significantly different (p = 0.011). The mean gestational ages were 36, 37 and 37 weeks in DA, JIA and CA, respectively (p-NS). Associated congenital anomalies were seen in 41 (76%) DA, 32 (52%) JIA and 3 (38%) CA (p = 0.08, NS). The median time to full oral feeds after surgery was 18 days in DA, 20 days in JIA and 15.6 days in CA, respectively (p > 0.05). Eight patients with DA and nine patients with JIA underwent repeat surgery for adhesive obstruction. Adhesive bowel obstruction was most common in the first year after surgery in both groups (15/17). Gastroschisis was seen in six (10%) of JIA and three (35%) of CA. Two patients in the JIA group underwent bowel lengthening. Patients with gastroschisis and those with associated anomalies needed prolonged duration of TPN after JIA correction. There was no mortality in the duodenal atresia and colonic atresia groups. Six patients in the JIA group died, three of severe atresias coupled with multiple anomalies and three of cholestasis and sepsis.

Conclusion

Distal atresias are difficult to diagnose antenatally. Proximal atresias have a significantly lower birth weight than distal atresias. Associated anomaly screening is important in all atresias.

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Authors and Affiliations

  1. Division of Pediatric Surgery, Department of Surgery, New York Medical College, 321 Munger Pavilion, Valhalla, New York, NY, 10595, USA

    Sathyaprasad Burjonrappa

  2. Hospital Ste Justine, University of Montreal, Montreal, QC, H3T 1C5, Canada

    Sathyaprasad Burjonrappa, Elise Crete & Sarah Bouchard

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  1. Sathyaprasad Burjonrappa
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  2. Elise Crete
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  3. Sarah Bouchard
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Correspondence to Sathyaprasad Burjonrappa.

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Burjonrappa, S., Crete, E. & Bouchard, S. Comparative outcomes in intestinal atresia: a clinical outcome and pathophysiology analysis. Pediatr Surg Int 27, 437–442 (2011). https://doi.org/10.1007/s00383-010-2729-8

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  • DOI: https://doi.org/10.1007/s00383-010-2729-8

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