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Oxidative stress profile in the post-operative patients with biliary atresia

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Abstract

Background and purpose

Many post-operative patients with biliary atresia (BA) suffer from liver dysfunction, such as chronic inflammation even without jaundice after a Kasai’s hepatic portoenterostomy.

Methods

The presence and degree of oxidative stress were evaluated in the post-operative patients with BA. Twelve outpatients who underwent a Kasai’s hepatic portoenterostomy were evaluated. The active oxygen products, the rate of bioantioxidant, the markers of oxidative stress, and the degree of hepatic oxidative stress were examined by immunohistochemical staining of biopsied specimens.

Results

All of the oxidative stress markers in the post-operative patients with BA increased in comparison to those in the controls. Moreover, 8-OHdG immunohistochemical staining was positive in 84 ± 4.8% in hepatic cells in the portal area in the post-operative patients with BA.

Conclusion

The post-operative patients with BA were under increased oxidative stress, even if their liver dysfunction was mild without jaundice. Antioxidant therapy might be necessary to decrease of oxidative stress in the post-operative patients with BA.

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Authors and Affiliations

  1. Department of Pediatric Surgery, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka, 830-0011, Japan

    Takahiro Asakawa, Yoshiaki Tanaka, Kimio Asagiri, Hidefumi Kobayashi & Minoru Yagi

  2. Department of Pathology, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka, 830-0011, Japan

    Ken Tanikawa

Authors
  1. Takahiro Asakawa
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  2. Yoshiaki Tanaka
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  3. Kimio Asagiri
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  4. Hidefumi Kobayashi
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  5. Ken Tanikawa
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  6. Minoru Yagi
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Correspondence to Takahiro Asakawa.

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Asakawa, T., Tanaka, Y., Asagiri, K. et al. Oxidative stress profile in the post-operative patients with biliary atresia. Pediatr Surg Int 25, 93–97 (2009). https://doi.org/10.1007/s00383-008-2284-8

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  • DOI: https://doi.org/10.1007/s00383-008-2284-8

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