Skip to main content
SpringerLink
Log in

Giant gastrinoma in a child: case report and review

  • Case Report
  • Published:
Pediatric Surgery International Aims and scope Submit manuscript

Abstract

Gastrinomas are rare neuroendocrine tumours. A 9-year-old boy who initially presented with recurrent upper abdominal pain and was managed as hyperacidity syndrome was later diagnosed to have a primary, retroperitoneal, extra pancreatic gastrinoma after an asymptomatic period of 6 years is presented. At the second presentation, the contrast-enhanced CT revealed an epigastric mass and serum gastrin was grossly elevated. A complete excision of the mass was done; histopathological evaluation showed a well-differentiated neuroendocrine tumour. At a year follow up, the child is asymptomatic and the review imaging and serum gastrin levels are normal.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Anlauf M, Garbrecht N, Henopp T, Schmitt A, Schlenger R, Raffel A et al (2006) Sporadic versus hereditary gastrinomas of the duodenum and pancreas: distinct clinico-pathological and epidemiological features. World J Gastroenterol 12:5440–5446

    PubMed  Google Scholar 

  2. Cisco RM, Norton JA (2007) Surgery for gastrinoma. Adv Surg 41:165–176. doi:10.1016/j.yasu.2007.05.010

    Article  PubMed  Google Scholar 

  3. Creutzfeldt W, Arnold R, Creutzfeldt C, Track NS (1975) Pathomorphologic, biochemical and diagnostic aspects of gastrinomas (Zollinger-Ellison syndrome). Hum Pathol 6:47–76. doi:10.1016/S0046-8177(75)80109-2

    Article  PubMed  CAS  Google Scholar 

  4. Donow C, Pipeleers-Marichal M, Schröder S, Stamm B, Heitz PU, Klöppel G (1991) Surgical pathology of gastrinoma. Site, size, multicentricity, association with multiple endocrine neoplasia type 1, and malignancy. Cancer 68(6):1329–1334. doi : 10.1002/1097-0142(19910915)68:6<1329::AID-CNCR2820680624>3.0.CO;2-7

    Article  PubMed  CAS  Google Scholar 

  5. Gibril F, Jensen RT (2004) Zollinger-Ellison syndrome revisited: diagnosis, biologic markers, associated inherited disorders, and acid hypersecretion. Curr Gastroenterol Rep 6:454–463. doi:10.1007/s11894-004-0067-5

    Article  PubMed  Google Scholar 

  6. Goldfinger SE (2004) Clinical manifestations and diagnosis of Zollinger-Ellison syndrome (gastrinoma), version 12.3. http://www.uptodateonline.com. Accessed 18 Feb 2004

  7. Gumbs AA, Moore PS, Falconi M, Bassi C, Beghelli S, Modlin I et al (2002) Review of the clinical, histological, and molecular aspects of pancreatic endocrine neoplasms. J Surg Oncol 81:45–53. doi:10.1002/jso.10142

    Article  PubMed  CAS  Google Scholar 

  8. House MG, Schulick RD (2006) Endocrine tumors of the pancreas. Endocrine tumors. Curr Opin Oncol 18(1):23–29. doi:10.1097/01.cco.0000198974.59239.3c

    Article  PubMed  Google Scholar 

  9. Isenberg JI, Walsh JH, Grossman MI (1973) Zollinger-Ellison syndrome. Gastroenterology 65:140–165

    PubMed  CAS  Google Scholar 

  10. Jensen RT (1998) Management of the Zollinger-Ellison syndrome in patients with multiple endocrine neoplasia type 1. J Intern Med 243:477–488. doi:10.1046/j.1365-2796.1998.00281.x

    Article  PubMed  CAS  Google Scholar 

  11. Marx SJ, Agarwal SK, Kester MB, Heppner C, Kim YS, Skarulis MC et al (1999) Multiple endocrine neoplasia type 1: clinical and genetic features of the hereditary endocrine neoplasias. Recent Prog Horm Res 54:397–438

    PubMed  CAS  Google Scholar 

  12. Norton JA (1999) Intraoperative methods to stage and localize pancreatic and duodenal tumors. Ann Oncol 10(Suppl 4):182–184. doi:10.1023/A:1008306802058

    Article  PubMed  Google Scholar 

  13. Norton JA, Fraker DL, Alexander HR, Venzon DJ, Doppman JL, Serrano J et al (1999) Surgery to cure the Zollinger-Ellison syndrome. N Engl J Med 341:635–644. doi:10.1056/NEJM199908263410902

    Article  PubMed  CAS  Google Scholar 

  14. Norton JA, Jensen RT (2004) Resolved and unresolved controversies in the surgical management of patients with Zollinger-Ellison syndrome. Ann Surg 240:757–773. doi:10.1097/01.sla.0000143252.02142.3e

    Article  PubMed  Google Scholar 

  15. Norton JA, Fraker DL, Alexander HR, Gibril F, Liewehr DJ, Venzon DJ, Jensen RT (2006) Surgery increases survival in patients with Gastrinoma. Tran Meet Am Surg Assoc 124:76–85

    Article  Google Scholar 

  16. Rösch T, Lightdale CJ, Botet JF, Boyce GA, Sivak MV Jr, Yasuda K et al (1992) Localization of pancreatic endocrine tumours by endoscopic ultrasonography. N Engl J Med 326:1721–1726

    PubMed  Google Scholar 

  17. Roy PK, Venzon DJ, Shojamanesh H, Abou-Saif A, Peghini P, Doppman JL et al (2000) Zollinger-Ellison syndrome. Clinical presentation in 261 patients. Medicine (Baltim) 79(6):379–411. doi:10.1097/00005792-200011000-00004

    Article  CAS  Google Scholar 

  18. Stabile BE, Morrow DJ, Passaro E (1984) The gastrinoma triangle: operative implications. Am J Surg 147:25–31. doi:10.1016/0002-9610(84)90029-1

    Article  PubMed  CAS  Google Scholar 

  19. Tudor RB (1988) Childhood disease registry. Bismuth ND

  20. Weber HC, Venzon DJ, Lin JT, Fishbein VA, Orbuch M, Strader DB et al (1995) Determinants of metastatic rate and survival in patients with Zollinger-Ellison syndrome: a prospective long-term study. Gastroenterology 108:1637–1649. doi:10.1016/0016-5085(95)90124-8

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Paediatric Surgery, St. John’s Medical College and Hospital, Johnnagara, Bangalore, 560034, India

    Subramanya Kattepura & Kanishka Das

  2. Department of Pathology, St. John’s Medical College and Hospital, Johnnagara, Bangalore, 560034, India

    Marjorie Mariam Ann Correa

  3. Department of Gastroenterology, St. John’s Medical College and Hospital, Johnnagara, Bangalore, 560034, India

    Harshad Devarabhavi

Authors
  1. Subramanya Kattepura
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kanishka Das
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Marjorie Mariam Ann Correa
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Harshad Devarabhavi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kanishka Das.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kattepura, S., Das, K., Correa, M.M.A. et al. Giant gastrinoma in a child: case report and review. Pediatr Surg Int 24, 1083–1085 (2008). https://doi.org/10.1007/s00383-008-2216-7

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00383-008-2216-7

Keywords

Search

Navigation