Abstract
Chest wall reconstruction following major tumour resection remains a challenging problem in the paediatric population due to the need for growth and development following the repair. Synthetic non-biodegradable grafts and materials have led to asymmetrical growth and significant functional and cosmetic compromise. The ideal graft material should be biological non-immunogenic which enables natural healing and facilitates further growth. Ewing’s sarcoma is an uncommon primitive neuroectodermal tumour which rarely occurs in the ribs. However, recent improvements in management have produced a significantly improved survival; increasing the importance of chest wall reconstruction. We prospectively assessed the utilisation of Surgisis (an acellular collagen matrix) as a replacement graft in two children undergoing primary chest wall reconstruction following tumour resection. Surgisis is derived from porcine small intestinal submucosa (SIS) that serves as a template for tissue reconstruction and remodeling. The graft was well tolerated; there was no herniation and it allowed normal symmetrical chest movement and growth to occur. The properties of SIS allows natural collagen growth and compares favourably with marlex mesh and other forms of chest wall reconstruction. We believe its unique properties allow it to act as a suitable framework for chest wall reconstruction allowing chest wall growth and development.
Similar content being viewed by others
References
Jenkins RD, Al-Fawaz I, Al-Shabanah M et al (2002) Localised Ewing sarcoma/PNET of bone-prognostic factors and international data comparison. Med Pediatr Oncol 39:586–593
Ramming KP, Holmes EC, Zare HA et al (1982) Surgical management and reconstruction of extensive chest wall malignancies. Am J Surg 144:146–152
Dang NC, Siegel S, Philips JD (1999) Malignant chest wall tumors in children and young adults. J Pediatr Surg 34:1773–1778
King RM, Pairolero PC, Trastek VF et al (1986) Primary chest wall tumors: factors affecting survival. Ann Thorac Surg 41:597–601
Mansour KA, Thourani VH, Losken A et al (2002) Chest wall resections and reconstruction: a 25-year experience. Ann Thorac Surg 73:1720–1725
Arnold PG, Pairolero PC (1996) Chest-wall reconstruction: an account of 500 consecutive patients. Plast Reconstr Surg 98:804–810
Mizuno T, Sano M, Iizuka M et al (1996) A clinical evaluation of chest wall reconstruction. Kyobu Geka 49:31–37
Ansaloni L, Catena F, D’Alessandro L (2003) Prospective randomized, double-blind, controlled trial comparing Lichtenstein’s repair of inguinal hernia with polypropylene mesh versus Surgisis gold soft tissue graft: preliminary results. Acta Biomed Ateneo Parmense 74 Suppl 2:10–14
Holcomb GW, Ostlie DJ, Miller KA (2005) Laparoscopic patch repair of diaphragmatic hernias with Surgisis. J Pediatr Surg 40:E1–E5
Helton WS, Fisichella PM, Berger R et al (2005) Short-term outcomes with small intestinal submucosa for ventral abdominal hernia. Arch Surg 140:549–560
Gabriel A, Gollins D (2006) Management of complicated gastroschisis with porcine small intestinal submucosa and negative pressure wound therapy. J Pediatr Surg 41:1836–1840
Spiegel JH, Kessler JL (2005) Tympanic membrane perforation repair with acellular porcine submucosa. Otol Neurotol 26:563–566
Ambro BT, Zimmerman J, Rosenthal M et al (2003) Nasal septal perforation repair with porcine small intestinal submucosa. Arch Facial Plast Surg 5:528–529
Smith MJ, Paran TS Quinn F, Corbally MT (2004) The SIS extracellular matrix scaffold-preliminary results of use in congenital diaphragmatic hernia (CDH) repair. Pediatr Surg Int 20:859–862
Pairolero PC (1995) Surgical management of the neoplasms of the chest wall. In: Sabitos DC, Spencer FC (eds) Surgery of the Chest, 6th edn. WB Saunders, Philadelphia pp 516–521
Denner J (2003) Porcine endogenous retroviruses (PERVs) and xenotransplantation: screening for transmission in several clinical trials and in experimental models using non-human primates. Ann Transplant 8:39–48
Specke V, Schuurman HJ, Plesker R et al (2002) Virus safety in xenotransplantation: first exploratory in vivo studies in small laboratory animals and non-human primates. Transpl Immunol 9:281–288
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Murphy, F., Corbally, M.T. The novel use of small intestinal submucosal matrix for chest wall reconstruction following Ewing’s tumour resection. Pediatr Surg Int 23, 353–356 (2007). https://doi.org/10.1007/s00383-007-1882-1
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00383-007-1882-1