Pediatric Surgery International

, Volume 22, Issue 4, pp 316–318 | Cite as

Long-term outcome of patients with enterocolitis complicating Hirschsprung’s disease

  • Maria Menezes
  • Prem PuriEmail author
Original Article


Enterocolitis remains the most serious complication of Hirschsprung’s disease (HD). The purpose of this study was to evaluate the risk factors in the development of enterocolitis and the long-term outcome in these patients. The hospital records of 259 consecutive patients with HD during 1975–2003 were examined. The data was analysed for age at presentation, associated anomalies, level of aganglionosis, clinical features, number of episodes of enterocolitis, type of pullthrough, necessity for post-pullthrough sphincterectomy. Follow up was carried out by personal interviews and interviews over the telephone with patients/parents. Enterocolitis was diagnosed on the basis of clinical features of diarrhoea, pyrexia, abdominal distention and vomiting. Of the 259 patients with HD, 74 patients (28.5%) were found to have enterocolitis. Out of 39 patients with Down’s syndrome and HD, 19 (48%) had enterocolitis. Fifteen (20%) patients had other associated anomalies. Fifty-six patients (75.6%) were male and 18 (24.3%) were female. In 30 patients enterocolitis was the presenting feature in the neonatal period, 22 of which presented in the first 2 weeks of life. Fifty-six patients (75.6%) had rectosigmoid disease and 18 (24.3%) had long segment disease or total colonic aganglionosis. Eighteen (24.3%) had only preoperative enterocolitis and 31(41.8%) had only postoperative enterocolitis. Twenty-five (33.7%) had both pre- and post-operative enterocolitis. Twenty (27%) patients had more than 2 episodes of enterocolitis. Various pullthrough procedures were performed. Twenty-six patients (35.1%) required internal sphinctermyectomy to treat the enterocolitis. At the time of follow-up, 16 patients were lost to follow-up. Of the remaining 58 patients, 3 patients died, 2 due to enterocolitis and 1 due to sepsis. Six patients remained with a stoma. Twenty-two patients were continent and were stooling normally, but 14 of these were on laxatives for several years after pullthrough procedure. The mean age at achieving full continence was 4.95 years in the 22 patients with normal bowel function. Nineteen patients are still on laxatives and 8 patients are soiling. Eight patients continue to have multiple recurrent episodes of enterocolitis at follow-up. Down’s syndrome is an important risk factor in the development of enterocolitis. The majority of patients with enterocolitis complicating HD continue to have disturbances of bowel function many years after surgery for HD.


Hirschsprung’s disease Enterocolitis Risk factors Bowel function 


  1. 1.
    Teitelbaum DH, Qualman SJ, Caniano DA (1998) Hirschsprung’s disease. Identification of risk factors for enterocolits. Ann Surg 207:240–244CrossRefGoogle Scholar
  2. 2.
    Surana R, Quinn FMJ, Puri P (1994) Evaluation of risk factors in the development of enterocolitis complicating Hirschsprung’s disease. Pediatr Surg Int 9:234–236CrossRefGoogle Scholar
  3. 3.
    Carneiro PMR, Brereton RJ, Drake DP, Kiely EM, Spitz L, Turnock R (1992) Enterocolitis in Hirschsprung’s disease. Pediatr Surg Int 7:356–360CrossRefGoogle Scholar
  4. 4.
    Quinn FMJ, Surana R, Puri P (1994) Influence of trisomy 21 on the outcome in children with Hirschsprung’s disease. J Pediatr Surg 29:781–783PubMedCrossRefGoogle Scholar
  5. 5.
    Menezes M, Puri P (2005) Long term clinical outcome in patients with Hirschsprung’s disease and associated Down’s syndrome. J Pediatr Surg 40:810–812CrossRefPubMedGoogle Scholar
  6. 6.
    Hackam DJ, Filler RM, Pearl RH (1998) Enterocolitis after the surgical treatment of Hirschsprung’s disease. Risk factors and financial impact. J Pediatr Surg 33:830–833CrossRefPubMedGoogle Scholar
  7. 7.
    Teitelbaum DH, Coran AG (2003) Re-operative surgery for Hirschsprung’s disease. Semin Pediatr Surg 12(2):124–131CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  1. 1.Children’s Research CentreOur Lady’s Hospital for Sick Children, CrumlinDublin 12Ireland

Personalised recommendations