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Gastrointestinal stromal tumour presenting with severe bleeding: a review of the molecular biology

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Gastrointestinal stromal tumours (GIST) are rare in children. A 7-year-old boy presented acutely with a severe upper gastrointestinal bleed and was found following angiography to have such a tumour in the duodenum, which was resected at laparotomy. The presence of CD 117 positive immunostaining was a confirmatory diagnostic marker. The prognosis and underlying molecular biology of the tumour is discussed. Understanding of the molecular pathogenesis has given rise to promising new therapies.

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  1. Licht JD, Weissmann LB, Antman K (1988) Gastrointestinal sarcomas. Semin Oncol 15(2):181–188

    PubMed  CAS  Google Scholar 

  2. Miettinen M, Sarlomo-Rikala M, Lasota J (1999) Gastrointestinal stromal tumors: recent advances in understanding of their biology. Hum Pathol 30(10):1213–1220

    Article  PubMed  CAS  Google Scholar 

  3. Nishida T, Hirota S (2000) Biological and clinical review of stromal tumors in the gastrointestinal tract. Histol Histopathol 15(4):1293–1301

    PubMed  CAS  Google Scholar 

  4. Chadwick EG, Connor EJ, Hanson IC, Joshi VV, Abu-Farsakh H, Yogev R et al (1990) Tumors of smooth-muscle origin in HIV-infected children. Jama 263(23):3182–3184

    Article  PubMed  CAS  Google Scholar 

  5. Durham MM, Gow KW, Shehata BM, Katzenstein HM, Lorenzo RL, Ricketts RR (2004) Gastrointestinal stromal tumors arising from the stomach: a report of three children. J Pediatr Surg 39(10):1495–1499

    Article  PubMed  Google Scholar 

  6. Nilsson B, Bumming P, Meis-Kindblom JM, Oden A, Dortok A, Gustavsson B, Sablinska K, Kindblom LG (2005) Gastrointestinal stromal tumors: the incidence, prevalence, clinical course, and prognostication in the preimatinib mesylate era—a population-based study in western Sweden. Cancer 103(4):821–829

    Article  PubMed  Google Scholar 

  7. Tervit GJ, Forster AL (1997) Leiomyoma of the small intestine in an 11-year-old boy. Eur J Pediatr Surg 7(1):44

    Article  PubMed  CAS  Google Scholar 

  8. Li P, Wei J, West AB, Perle M, Greco MA, Yang GC (2002) Epithelioid gastrointestinal stromal tumor of the stomach with liver metastases in a 12-year-old girl: aspiration cytology and molecular study. Pediatr Dev Pathol 5(4):386–394

    Article  PubMed  Google Scholar 

  9. Emory TS, Sobin LH, Lukes L, Lee DH, O’Leary TJ (1999) Prognosis of gastrointestinal smooth-muscle (stromal) tumors: dependence on anatomic site. Am J Surg Pathol 23(1): 82–87

    Article  PubMed  CAS  Google Scholar 

  10. He LJ, Wang BS, Chen CC (1988) Smooth muscle tumours of the digestive tract: report of 160 cases. Br J Surg 75(2): 184–186

    Article  PubMed  CAS  Google Scholar 

  11. Carney JA, Sizemore GW, Sheps SG (1976) Adrenal medullary disease in multiple endocrine neoplasia, type 2: pheochromocytoma and its precursors. Am J Clin Pathol 66(2):279–290

    PubMed  CAS  Google Scholar 

  12. Fletcher CD, Berman JJ, Corless C, Gorstein F, Lasota J, Longley BJ, et al (2002) Diagnosis of gastrointestinal stromal tumors: a consensus approach. Hum Pathol 33(5):459–465

    Article  PubMed  Google Scholar 

  13. Franquemont DW (1995) Differentiation and risk assessment of gastrointestinal stromal tumors. Am J Clin Pathol 103(1):41–47

    PubMed  CAS  Google Scholar 

  14. Mazur MT, Clark HB (1983) Gastric stromal tumors. Reappraisal of histogenesis. Am J Surg Pathol 7(6):507–519

    Article  PubMed  CAS  Google Scholar 

  15. Blume-Jensen P, Claesson-Welsh L, Siegbahn A, Zsebo KM, Westermark B, Heldin CH (1991) Activation of the human c-kit product by ligand-induced dimerization mediates circular actin reorganization and chemotaxis. Embo J 10(13):4121–4128

    PubMed  CAS  Google Scholar 

  16. Heinrich MC, Blanke CD, Druker BJ, Corless CL (2002) Inhibition of KIT tyrosine kinase activity: a novel molecular approach to the treatment of KIT-positive malignancies. J Clin Oncol 20(6):1692–1703

    Article  PubMed  CAS  Google Scholar 

  17. Pidhorecky I, Cheney RT, Kraybill WG, Gibbs JF (2000) Gastrointestinal stromal tumors: current diagnosis, biologic behavior, and management. Ann Surg Oncol 7(9):705–712

    Article  PubMed  CAS  Google Scholar 

  18. Pierie JP, Choudry U, Muzikansky A, Yeap BY, Souba WW, Ott MJ (2001) The effect of surgery and grade on outcome of gastrointestinal stromal tumors. Arch Surg 36(4):383–389

    Google Scholar 

  19. Demetri GD, von Mehren M, Blanke CD, Van den Abbeele AD, Eisenberg B, Roberts PJ et al (2002) Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med 347(7): 472–480

    Article  PubMed  CAS  Google Scholar 

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Correspondence to E. Towu.

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Towu, E., Stanton, M. Gastrointestinal stromal tumour presenting with severe bleeding: a review of the molecular biology. Ped Surgery Int 22, 462–464 (2006).

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