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Gastrointestinal stromal tumour presenting with severe bleeding: a review of the molecular biology

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Abstract

Gastrointestinal stromal tumours (GIST) are rare in children. A 7-year-old boy presented acutely with a severe upper gastrointestinal bleed and was found following angiography to have such a tumour in the duodenum, which was resected at laparotomy. The presence of CD 117 positive immunostaining was a confirmatory diagnostic marker. The prognosis and underlying molecular biology of the tumour is discussed. Understanding of the molecular pathogenesis has given rise to promising new therapies.

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Authors and Affiliations

  1. Department of Paediatric Surgery, Lewisham University Hospital NHS Trust, Lewisham High Street, London, SE13 6LH, UK

    E. Towu & M. Stanton

  2. Southampton General Hospital, Southampton University NHS Trust, Tremona Road, Southampton, SO16 6YD, UK

    E. Towu & M. Stanton

Authors
  1. E. Towu
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  2. M. Stanton
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Correspondence to E. Towu.

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Towu, E., Stanton, M. Gastrointestinal stromal tumour presenting with severe bleeding: a review of the molecular biology. Ped Surgery Int 22, 462–464 (2006). https://doi.org/10.1007/s00383-006-1636-5

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  • DOI: https://doi.org/10.1007/s00383-006-1636-5

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