Pediatric Surgery International

, Volume 21, Issue 12, pp 969–972 | Cite as

Further experience with OK-432 for lymphangiomas

  • C. LuzzattoEmail author
  • R. Lo Piccolo
  • F. Fascetti Leon
  • G. F. Zanon
  • T. Toffolutti
  • A. Tregnaghi
Original Article


This study includes all the children treated with OK-432 for lymphangioma at our institute. Twenty-nine children treated between 1999 and 2003 are reported for the first time: twelve cases regressed completely, eight cases regressed more than 50% and seven remained unchanged; two cases were lost at follow-up. The outcome was related to the size of the cysts, the larger ones having a better prognosis. The adverse reactions are discussed and the methods of treatment are described in detail. Fifteen children, treated before 1999 and already reported, are reviewed after a long-term follow-up. Four had a recurrence: one regressed spontaneously and three needed further treatment. The other 11 had no complaints. Even considering the risk of recurrence, OK-432 therapy remains our first line therapy for lymphangiomas, avoiding surgery in most cases.


OK-432 Lymphangioma 


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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • C. Luzzatto
    • 1
    Email author
  • R. Lo Piccolo
    • 1
  • F. Fascetti Leon
    • 1
  • G. F. Zanon
    • 1
  • T. Toffolutti
    • 2
  • A. Tregnaghi
    • 2
  1. 1.Division of Pediatric SurgeryUniversity of PaduaPaduaItaly
  2. 2.Institute of RadiologyUniversity of PaduaPaduaItaly

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