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New insights into the pathogenesis of Hirschsprung’s associated enterocolitis

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An Erratum to this article was published on 17 November 2005

Abstract

The management of Hirschsprung’s disease (HD) has made dramatic strides over the last 20 years. Research into the embryological development and migration of ganglion cell has enabled a greater understanding of the pathogenesis of the disease. Coupled with new techniques in surgery, such as laparoscopy-assisted pull-through and the transanal pull-through, this knowledge has led to improved outcomes for children with HD. However, although our appreciation of Hirschsprung’s associated enterocolitis and its aetiology has increased, there are continued references in the literature to a multitude of theories of pathogenesis. The purpose of this review is to delineate the theories and demonstrate the evidence supporting or otherwise contradicting each other.

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  1. The Children’s Research Centre, Our Lady’s Hospital for Sick Children Crumlin, University College Dublin, Dublin 12, Ireland

    Feilim Murphy & Prem Puri

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  1. Feilim Murphy
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  2. Prem Puri
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Correspondence to Prem Puri.

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An erratum to this article can be found at http://dx.doi.org/10.1007/s00383-005-1570-y

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Murphy, F., Puri, P. New insights into the pathogenesis of Hirschsprung’s associated enterocolitis. Ped Surgery Int 21, 773–779 (2005). https://doi.org/10.1007/s00383-005-1551-1

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