Abstract
Desmoplastic small round cell tumour (DSRCT) is an extremely rare neoplasm. Adolescent males and young adults are most frequently affected. It is highly malignant, with only 29% of patients surviving up to 3 years. This paper documents two cases, one of which, at 4 years old, is the second youngest case documented. Case 1, a 10-year old boy, presented with a 20-day history of choluria, acholia, asthenia, anorexia, and right abdominal pain. Laboratory values were altered, and imaging showed multiples masses in the liver and retroperitoneum. A minilaparotomy was carried out, and a biopsy showed a stage III DSRCT. He was treated with chemotherapy but died of hepatic failure. Case 2, a 4-year-old boy, presented with a 2-month history of abdominal distension. Several hard masses were palpated in the abdomen, and a right inguinal mass that compressed the right testis was observed. Biopsy of the inguinal tumour showed a DSRCT. After treatment with chemotherapy, two operations were carried out to resect different intraabdominal masses. The patient died with peritoneal carcinomatosis 2 months after the last operation. The first patient died due to the advanced stage of the disease, and the second died after chemotherapy, peripheral blood stem transplantation, and multiple operations. The occurrence of this type of tumour in the paediatric age group as well as its high malignancy is noteworthy. Until more effective forms of treatment are found, we recommend treatment with chemotherapy, surgery, and radiotherapy, with close monitoring of the patient.
References
Sesterhenn I, Davis CJ, Mostofi FK (1987) Undifferentiated malignant epithelial tumors involving serosal surfaces of escrotum and abdomen in young males. J Urol 137:214A
Gerald WL, Rosai J (1989) Case 2: desmoplastic small round cell tumor with divergent differentiation. Pediatr Pathol 9:177–183
La Quaglia MP, Brennan MF (2000) The clinical approach to desmoplastic small round cell tumor. Surg Oncol 9:77–81
Kurre P, Felgenhauer JL, Miser JS, Patterson K, Hawkins DS (2000) Successful dose-intensive treatment of desmoplastic small round cell tumor in three children. J Pediatr Hematol Oncol 22(5):446–450
Ordoñez NG (1998) Desmoplastic small round cell tumor: I: a histopathologic study of 39 cases with emphasis on unusual histological patterns. Am J Surg Pathol 22(11):1303–1313
Schwarz RE, Gerald WL, Kushner BH, Coit DG, Brennan MF, La Quaglia MP (1998) Desmoplastic small round cell tumors: prognostic indicators and result of surgical management. Ann Surg Oncol 5(5):416–422
Amato RJ, Ellerhorst JA, Ayala AG (1996) Intraabdominal desmoplastic small cell tumor. Report and discussion of five cases. Cancer 78(4):845–851
Basade MM, Vege DS, Nair CN (1996) Intra-abdominal desmoplastic small round cell tumor in children: a clinico-pathologic study. Pediatr Hematol Oncol 13(1):95–99
Roganovich J, Bisogno G, Ceccheto G, D’Amore E, Carli M (1999) Paratesticular desmoplastic small round cell tumor: case report and review of the literature. J Surg Oncol 71(4):269–272
Baltogiannis N, Mavridis G, Keramidas D (2002) Intraabdominal desmoplastic small round cell tumour: report of two cases in pediatric patients. Eur J Pediatr Surg 12:333–336
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Mingo, L., Seguel, F. & Rollán, V. Intraabdominal desmoplastic small round cell tumour. Ped Surgery Int 21, 279–281 (2005). https://doi.org/10.1007/s00383-005-1401-1
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DOI: https://doi.org/10.1007/s00383-005-1401-1