Skip to main content
SpringerLink
Log in

The effects of orchidopexy and orchidectomy on testes of rats subjected to ipsilateral abdominal testis with vas deferens obstruction

  • Original Article
  • Published:
Pediatric Surgery International Aims and scope Submit manuscript

Abstract

An experimental study was planned to evaluate and compare the effects of orchidopexy and orchidectomy on the testes of rats subjected to unilateral abdominal testis with vas deferens obstruction. Four groups were established. Rats in the control group underwent a sham procedure. While the testis was maintained in the abdomen with the vas deferens ligated for 8 weeks in group 2, rats in groups 3 and 4 underwent orchidopexy or orchidectomy after 4 weeks. Remaining testes were harvested at the end of the 8-week period. Testis and body weights were obtained during harvest. Samples were evaluated through DNA flow cytometry, and percentages of haploid cells were determined. Groups were compared through unpaired t-test, and p-values less than 0.05 were considered significant. All three treatments had decreased testis weight over body weight values of ipsilateral testes. Ipsilateral orchidectomy increased the value among contralateral testes. However, none of the groups had a contralateral testicular value less than the sham-operated group. All three treatments decreased the percentage of haploid cells among ipsilateral testes, but only an abdominal testis was associated with a decrease in the percentage of haploid cells among contralateral testes. Maintaining a testis with an obstructed vas deferens in the abdomen for 8 weeks damages both ipsilateral and contralateral testes. Orchidopexy, while showing amelioration of the ipsilateral testis, spares the contralateral testis as well as orchidectomy. Orchidopexy for an undescended testis with vas deferens obstruction is a rational approach.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Andıran F, Okur HD, Kılınç A, Kılınç G, Tanyel FC (2000) Do experimentally induced ipsilateral testicular torsion, vas deferens obstruction, intraabdominal testis or venous obstruction damage the contralateral testis through a common mechanism? BJU Int 85:330–335

    Article  CAS  PubMed  Google Scholar 

  2. Antypas S, Sofikitis N, Rodriguez F, Zavos PM, Miyagawa I (1994) Bilateral effect of unilateral vasectomy on testicular testosterone biosynthesis. J Pediatr Surg 29:828–831

    Article  CAS  PubMed  Google Scholar 

  3. Chan LS, Lipshultz LI, Schwartzendruber D (1984) Deoxyribonucleic acid flow cytometry: a new modality for quantitative analysis of testicular biopsies. Fertil Steril 41:485–487

    CAS  PubMed  Google Scholar 

  4. Fonkalsrud EW (1987) Testicular undescent and torsion. Pediatr Clin North Am 34:1305–1317

    CAS  PubMed  Google Scholar 

  5. Gill B, Kogan S, Starr S, Reda E, Levitt S (1989) Significance of epididymal and ductal anomalies associated with testicular maldescent. J Urol 142:556–558

    CAS  PubMed  Google Scholar 

  6. Hashimoto O (1984) Flow cytometric analysis of DNA in testicular cells of Wistar rats. Nishinihon J Urol 46:533–539

    Google Scholar 

  7. Hellstrom WJ, Tesluk H, Deitch AD, de Vere White RW (1990) Comparison of flow cytometry to routine testicular biopsy in male infertility. Urology 35:321–326

    CAS  PubMed  Google Scholar 

  8. Hittmair A, Rogatsch H, Offner F, Feichtinger H, Ofner D, Mikuz G (1992) Deoxyribonucleic acid flow cytometry and semi-quantitative histology of spermatogenesis: a comparative study. Fertil Steril 58:1040–1045

    CAS  PubMed  Google Scholar 

  9. Hurwitz RS, Kaptein JS (2001) How well does contralateral testis hypertrophy predict the absence of the nonpalpable testis? J Urol 165:588–592

    Article  CAS  PubMed  Google Scholar 

  10. Karnak İ, Gedikoğlu G, Tanyel FC, Büyükpamukçu N, Hiçsönmez A (1996) The effects of chemical sympathectomy on contralateral testicular histology, fertility and fecundity in unilateral abdominal testis. Br J Urol 77:580–584

    Article  CAS  PubMed  Google Scholar 

  11. Kawai S (1985) DNA flow cytometric evaluation of spermatogenesis. Acta Urol Jpn 31:147–151

    Google Scholar 

  12. Matsuda T, Horii Y, Yoshida O (1992) Unilateral obstruction of vas deferens caused by childhood inguinal herniorrhaphy in male infertility patients. Fertil Steril 58:609–613

    CAS  PubMed  Google Scholar 

  13. Mollaeian M, Mehrabi V, Elahi B (1994) Significance of epididymal and ductal anomalies associated with undescended testis: study in 652 cases. Urology 43:857–860

    Article  CAS  PubMed  Google Scholar 

  14. Oğuzkurt P, Okur HD, Tanyel FC, Büyükpamukçu N, Hiçsönmez A (1998) The effects of vasodilatation and chemical sympathectomy on spermatogenesis after unilateral testicular torsion: a flow cytometric DNA analyses. Br J Urol 82:104–108

    Article  PubMed  Google Scholar 

  15. Parkhouse H, Hendry WF (1991) Vasal injuries during childhood and their effects on subsequent fertility. Br J Urol 67:91–95

    CAS  PubMed  Google Scholar 

  16. Patkowski D, Czernik J, Jeleń M (1992) The natural course of cryptorchidism in rats and the efficacy of orchidopexy or orchidectomy in its treatment before and after puberty. J Pediatr Surg 27:870–873

    Article  CAS  PubMed  Google Scholar 

  17. Quinn FM, Crockard AD, Brown S (1991) Reversal of degenerative changes in the scrotal testis after orchidopexy in experimental unilateral cryptorchidism. J Pediatr Surg 26:451–454

    Article  CAS  PubMed  Google Scholar 

  18. Salman AB, Okur HD, Tanyel FC (1998) DNA flow cytometry reveals depressed spermatogenetic activity in the contralateral testis within 24 h of ipsilateral spermatic cord torsion independently of the presence of the testis and epididymis. Eur Urol 34:377–381

    Article  CAS  PubMed  Google Scholar 

  19. Türken A, Okur HD, Gedikoğlu G, Tanyel FC (2001) Effects of abdominal location and epididymal or vasal obstructions either individually or in association on ipsilateral and contralateral testes. Eur Urol 39:449–454

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatric Surgery, Hacettepe University Faculty of Medicine, 06100, Ankara, Turkey

    S. Otçu, İ Karnak & F. C. Tanyel

  2. Pediatric Hematology Unit, Hacettepe University Faculty of Medicine, 06100, Ankara, Turkey

    H. D. Okur

Authors
  1. S. Otçu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. İ Karnak
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H. D. Okur
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. F. C. Tanyel
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to F. C. Tanyel.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Otçu, S., Karnak, İ., Okur, H.D. et al. The effects of orchidopexy and orchidectomy on testes of rats subjected to ipsilateral abdominal testis with vas deferens obstruction. Ped Surgery Int 20, 614–617 (2004). https://doi.org/10.1007/s00383-004-1242-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00383-004-1242-3

Keywords

Search

Navigation